Gene description for TRRAP
Gene name transformation/transcription domain-associated protein
Gene symbol TRRAP
Other names/aliases PAF350/400
PAF400
STAF40
TR-AP
Tra1
Species Homo sapiens
 Database cross references - TRRAP
ExoCarta ExoCarta_8295
Vesiclepedia VP_8295
Entrez Gene 8295
HGNC 12347
MIM 603015
UniProt Q9Y4A5  
 TRRAP identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Thymus 23844026    
 Gene ontology annotations for TRRAP
Molecular Function
    transcription coregulator activity GO:0003712 IDA
    protein binding GO:0005515 IPI
    kinase activity GO:0016301 IKR
Biological Process
    regulation of DNA repair GO:0006282 NAS
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of DNA-templated transcription GO:0006355 NAS
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    regulation of apoptotic process GO:0042981 NAS
    regulation of RNA splicing GO:0043484 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    regulation of cell cycle GO:0051726 IMP
    DNA repair-dependent chromatin remodeling GO:0140861 IBA
    positive regulation of double-strand break repair via homologous recombination GO:1905168 IDA
    regulation of double-strand break repair GO:2000779 NAS
Subcellular Localization
    SAGA complex GO:0000124 IBA
    SAGA complex GO:0000124 IDA
    SAGA complex GO:0000124 NAS
    nucleosome GO:0000786 IDA
    Swr1 complex GO:0000812 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    Golgi apparatus GO:0005794 IDA
    transcription factor TFTC complex GO:0033276 IDA
    transcription factor TFTC complex GO:0033276 NAS
    NuA4 histone acetyltransferase complex GO:0035267 IBA
    NuA4 histone acetyltransferase complex GO:0035267 IDA
 Experiment description of studies that identified TRRAP in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRRAP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 TADA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SOX3  
Affinity Capture-MS Homo sapiens
4 SENP3 26168
Affinity Capture-MS Homo sapiens
5 HIST1H2BE 8344
Affinity Capture-MS Homo sapiens
6 NCBP1 4686
Affinity Capture-MS Homo sapiens
7 MBTD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
8 CACNG5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ELF1 1997
Proximity Label-MS Homo sapiens
10 MED17  
Co-purification Homo sapiens
11 STAT2 6773
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 Ruvbl1 56505
Affinity Capture-MS Mus musculus
13 KPNA1 3836
Affinity Capture-MS Homo sapiens
14 CDKN1A  
Affinity Capture-Western Homo sapiens
15 ATXN7L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
17 TADA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 NFATC1 4772
Affinity Capture-MS Homo sapiens
19 E2F1 1869
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 ACTC1 70
Affinity Capture-MS Homo sapiens
21 TTI1 9675
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
22 KIF20A 10112
Affinity Capture-MS Homo sapiens
23 ZZZ3  
Affinity Capture-MS Homo sapiens
24 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
25 MED24 9862
Co-purification Homo sapiens
26 SOX9  
Proximity Label-MS Homo sapiens
27 ELF4 2000
Proximity Label-MS Homo sapiens
28 SF3B5 83443
Affinity Capture-MS Homo sapiens
29 MYOD1  
Proximity Label-MS Homo sapiens
30 JAZF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MED13 9969
Co-purification Homo sapiens
32 RUVBL1 8607
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 WDR76  
Affinity Capture-MS Homo sapiens
34 MEAF6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PRC1 9055
Affinity Capture-MS Homo sapiens
36 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
37 TELO2 9894
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 ING3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 ZNF148  
Affinity Capture-Western Homo sapiens
40 FOXR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 OBSL1 23363
Affinity Capture-MS Homo sapiens
42 BRINP1  
Affinity Capture-MS Homo sapiens
43 PLAC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 ZXDB  
Affinity Capture-MS Homo sapiens
45 EED  
Affinity Capture-MS Homo sapiens
46 USP27X  
Affinity Capture-MS Homo sapiens
47 YEATS2  
Affinity Capture-MS Homo sapiens
48 BTAF1 9044
Co-fractionation Homo sapiens
49 LHX4  
Proximity Label-MS Homo sapiens
50 MECP2 4204
Affinity Capture-MS Homo sapiens
51 CUL1 8454
Affinity Capture-Western Homo sapiens
52 MYCN  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
53 USP7 7874
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
54 NCK1 4690
Affinity Capture-MS Homo sapiens
55 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 TAF5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 VPS72  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 USP22 23326
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 MED1 5469
Co-purification Homo sapiens
60 E2F4  
Affinity Capture-Western Homo sapiens
61 H2AFZ 3015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
63 MRE11A 4361
Affinity Capture-Western Homo sapiens
64 CTDP1 9150
Affinity Capture-MS Homo sapiens
65 TAF10 6881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 SUPT7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 DOT1L 84444
Affinity Capture-MS Homo sapiens
68 RPA4  
Proximity Label-MS Homo sapiens
69 NFIX 4784
Proximity Label-MS Homo sapiens
70 OFD1 8481
Affinity Capture-Western Homo sapiens
71 TAF9B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 MED14  
Co-purification Homo sapiens
73 SREBF2 6721
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
74 TAF12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 ACTL6A 86
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
76 MED12  
Co-purification Homo sapiens
77 MED26  
Co-purification Homo sapiens
78 CRYAA 1409
Affinity Capture-MS Homo sapiens
79 SUPT3H  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 HIST1H2BG 8339
Affinity Capture-MS Homo sapiens
81 CCDC101  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 MED25  
Co-purification Homo sapiens
83 HECTD1 25831
Affinity Capture-MS Homo sapiens
84 ENY2 56943
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 BRD4 23476
Affinity Capture-MS Homo sapiens
86 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 MYCL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 KLF12  
Proximity Label-MS Homo sapiens
89 CEBPA  
Protein-peptide Homo sapiens
90 TAF6L 10629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 MED15  
Co-purification Homo sapiens
92 CD3EAP  
Proximity Label-MS Homo sapiens
93 YEATS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 Myc  
Affinity Capture-Western Mus musculus
95 TAF7  
Co-fractionation Homo sapiens
96 GAN 8139
Affinity Capture-MS Homo sapiens
97 CSRP2BP  
Affinity Capture-MS Homo sapiens
98 ECT2 1894
Affinity Capture-MS Homo sapiens
99 SIRT7  
Affinity Capture-MS Homo sapiens
100 TAL1  
Affinity Capture-MS Homo sapiens
101 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
102 SREBF1 6720
Affinity Capture-Western Homo sapiens
103 BRD8 10902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 CIT 11113
Affinity Capture-MS Homo sapiens
105 EGFR 1956
Negative Genetic Homo sapiens
106 YY1 7528
Proximity Label-MS Homo sapiens
107 MRGBP  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 EP400  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 MORF4L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 CREB3L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 OCIAD1 54940
Affinity Capture-MS Homo sapiens
112 AURKB 9212
Affinity Capture-MS Homo sapiens
113 HNF4A  
Proximity Label-MS Homo sapiens
114 DMAP1 55929
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
116 TADA2A  
Affinity Capture-MS Homo sapiens
117 MYC  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Dosage Lethality Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
118 RPA3 6119
Proximity Label-MS Homo sapiens
119 SOHLH1  
Affinity Capture-MS Homo sapiens
120 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 WDR37 22884
Affinity Capture-MS Homo sapiens
122 ING5  
Affinity Capture-MS Homo sapiens
123 KAT5  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 MED23 9439
Co-purification Homo sapiens
125 SF3B3 23450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 PYGO2  
Reconstituted Complex Homo sapiens
127 TADA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 NFATC2  
Affinity Capture-MS Homo sapiens
129 HIST1H2BI 8346
Affinity Capture-MS Homo sapiens
130 TAF4 6874
Co-fractionation Homo sapiens
131 HIF1A 3091
Affinity Capture-MS Homo sapiens
132 ZRANB1 54764
Affinity Capture-MS Homo sapiens
133 TAF6 6878
Affinity Capture-Western Homo sapiens
134 TAF5  
Affinity Capture-Western Homo sapiens
135 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
136 Ruvbl2 20174
Affinity Capture-MS Mus musculus
137 FOXO3  
Affinity Capture-MS Homo sapiens
138 CDC20 991
Affinity Capture-Western Homo sapiens
139 SIRT6  
Affinity Capture-MS Homo sapiens
140 MAX  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 KAT2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
142 SUPT20H 55578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
144 CDK8 1024
Co-purification Homo sapiens
145 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 TRIM52  
Affinity Capture-MS Homo sapiens
147 KAT2B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 ATXN7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
149 MEN1 4221
Affinity Capture-MS Homo sapiens
150 DR1  
Affinity Capture-MS Homo sapiens
151 RPS12 6206
Cross-Linking-MS (XL-MS) Homo sapiens
152 SKP1 6500
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
153 NPAT  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
154 MORF4L2  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 EPC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 KRT72 140807
Affinity Capture-MS Homo sapiens
157 MKI67  
Affinity Capture-MS Homo sapiens
158 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
159 Myh10 77579
Affinity Capture-MS Mus musculus
160 ESR1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
161 MED16 10025
Co-purification Homo sapiens
162 TTI2 80185
Affinity Capture-MS Homo sapiens
163 EDC4 23644
Affinity Capture-MS Homo sapiens
164 ING1  
Affinity Capture-Western Homo sapiens
165 MBIP  
Affinity Capture-MS Homo sapiens
166 AURKA 6790
Reconstituted Complex Homo sapiens
167 ELF2  
Proximity Label-MS Homo sapiens
168 C14orf169  
Affinity Capture-Western Homo sapiens
169 TCF3  
Reconstituted Complex Homo sapiens
170 TAF9 6880
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens