Gene description for USP22
Gene name ubiquitin specific peptidase 22
Gene symbol USP22
Other names/aliases USP3L
Species Homo sapiens
 Database cross references - USP22
ExoCarta ExoCarta_23326
Vesiclepedia VP_23326
Entrez Gene 23326
HGNC 12621
MIM 612116
UniProt Q9UPT9  
 USP22 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for USP22
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    cysteine-type deubiquitinase activity GO:0004843 IDA
    cysteine-type deubiquitinase activity GO:0004843 IMP
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    histone H4 acetyltransferase activity GO:0010485 IDA
    enzyme binding GO:0019899 IPI
    nuclear receptor coactivator activity GO:0030374 IMP
    histone H2B deubiquitinase activity GO:0140936 IDA
    histone H2A deubiquitinase activity GO:0140950 IDA
Biological Process
    G2/M transition of mitotic cell cycle GO:0000086 IDA
    regulation of DNA repair GO:0006282 NAS
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    proteolysis GO:0006508 IEA
    embryo development ending in birth or egg hatching GO:0009792 NAS
    protein deubiquitination GO:0016579 IDA
    positive regulation of type I interferon production GO:0032481 IDA
    regulation of RNA splicing GO:0043484 NAS
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of mitotic cell cycle GO:0045931 IMP
Subcellular Localization
    SAGA complex GO:0000124 IDA
    SAGA complex GO:0000124 NAS
    nucleus GO:0005634 IC
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IC
    transcription factor TFTC complex GO:0033276 NAS
 Experiment description of studies that identified USP22 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for USP22
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TADA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ACTR2 10097
Affinity Capture-MS Homo sapiens
3 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ARPC5L 81873
Affinity Capture-MS Homo sapiens
5 TM4SF5  
Affinity Capture-MS Homo sapiens
6 TRRAP 8295
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ATXN7L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ARPC2 10109
Affinity Capture-MS Homo sapiens
9 TADA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 LRRN2 10446
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MRPL10 124995
Two-hybrid Homo sapiens
13 UBC 7316
Reconstituted Complex Homo sapiens
14 KIF7 374654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 KLHL23  
Affinity Capture-MS Homo sapiens
16 PRKDC 5591
Affinity Capture-MS Homo sapiens
17 MFAP5  
Affinity Capture-MS Homo sapiens
18 ATXN7L3B 552889
Affinity Capture-MS Homo sapiens
19 CAPZB 832
Affinity Capture-MS Homo sapiens
20 ATXN7L1 222255
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 TAF9 6880
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 CNOT10 25904
Affinity Capture-MS Homo sapiens
23 ACTR3 10096
Affinity Capture-MS Homo sapiens
24 RAB40C 57799
Affinity Capture-MS Homo sapiens
25 TMED2 10959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 CLEC2B  
Affinity Capture-MS Homo sapiens
27 KLF6  
Proximity Label-MS Homo sapiens
28 STAT3 6774
Affinity Capture-Western Homo sapiens
29 SRC 6714
Affinity Capture-Western Homo sapiens
30 YWHAG 7532
Affinity Capture-MS Homo sapiens
31 BMI1  
Affinity Capture-Western Homo sapiens
32 MTUS2 23281
Two-hybrid Homo sapiens
33 DEDD  
Affinity Capture-MS Homo sapiens
34 RCAN1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
35 MYO1B 4430
Affinity Capture-MS Homo sapiens
36 TACSTD2 4070
Affinity Capture-MS Homo sapiens
37 BRD4 23476
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 PLA2G10  
Affinity Capture-MS Homo sapiens
39 USP27X  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 AASDHPPT 60496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 LDLRAD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 MECP2 4204
Affinity Capture-MS Homo sapiens
43 MAVS 57506
Affinity Capture-Western Homo sapiens
44 PREPL 9581
Affinity Capture-MS Homo sapiens
45 RIC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 IFT20 90410
Affinity Capture-MS Homo sapiens
47 TAF5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 USP22 23326
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
49 ENPP6 133121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TCP1 6950
Affinity Capture-MS Homo sapiens
52 SCFD1 23256
Two-hybrid Homo sapiens
53 CDC23 8697
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
54 TAF10 6881
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 PTGS2 5743
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
56 SUPT7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DPP4 1803
Affinity Capture-Western Homo sapiens
58 PSME1 5720
Two-hybrid Homo sapiens
59 LCTL  
Affinity Capture-MS Homo sapiens
60 USP8 9101
Affinity Capture-MS Homo sapiens
61 TAF9B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 DNAJC5 80331
Affinity Capture-MS Homo sapiens
63 CCNB1 891
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
64 PABPC1 26986
Affinity Capture-MS Homo sapiens
65 CNOT1 23019
Affinity Capture-MS Homo sapiens
66 FUBP1 8880
Affinity Capture-Western Homo sapiens
67 FBXL22  
Affinity Capture-MS Homo sapiens
68 SUPT3H  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 HIST2H2AC 8338
Biochemical Activity Homo sapiens
70 DSP 1832
Affinity Capture-MS Homo sapiens
71 CCDC101  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 APBA1  
Affinity Capture-MS Homo sapiens
73 ENY2 56943
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 ARPC5 10092
Affinity Capture-MS Homo sapiens
75 IARS 3376
Affinity Capture-MS Homo sapiens
76 ITFG3 83986
Affinity Capture-MS Homo sapiens
77 SND1 27044
Affinity Capture-MS Homo sapiens
78 TMEM171  
Affinity Capture-MS Homo sapiens
79 CEBPA  
Protein-peptide Homo sapiens
80 GIP  
Affinity Capture-MS Homo sapiens
81 TAF6L 10629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 ZBED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 HIST2H2BE 8349
Biochemical Activity Homo sapiens
84 NT5E 4907
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 MRPL44  
Two-hybrid Homo sapiens
86 TAF12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 CYB5B 80777
Affinity Capture-MS Homo sapiens
88 HADHA 3030
Affinity Capture-MS Homo sapiens
89 NXF1 10482
Affinity Capture-RNA Homo sapiens
90 PPARG 5468
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
91 CD274 29126
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
92 CUL3 8452
Affinity Capture-MS Homo sapiens
93 FAM63B 54629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 EPRS 2058
Affinity Capture-MS Homo sapiens
95 CREB3L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 HEXA 3073
Two-hybrid Homo sapiens
97 TMEM173  
Affinity Capture-Western Homo sapiens
98 STAT1 6772
Affinity Capture-Western Homo sapiens
99 C3orf18  
Affinity Capture-MS Homo sapiens
100 MYC  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
101 SF3B3 23450
Affinity Capture-MS Homo sapiens
102 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 TADA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 CTDSP1 58190
Affinity Capture-MS Homo sapiens
105 NFATC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
106 BAG4  
Two-hybrid Homo sapiens
107 BIRC5  
Affinity Capture-Western Homo sapiens
108 USP51  
Affinity Capture-MS Homo sapiens
109 ARPC1A 10552
Affinity Capture-MS Homo sapiens
110 GYPA  
Affinity Capture-MS Homo sapiens
111 FASN 2194
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 CDC20 991
Affinity Capture-Western Homo sapiens
113 POFUT2 23275
Affinity Capture-MS Homo sapiens
114 KAT2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 SUPT20H 55578
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 RNF19B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 LDLRAD1  
Affinity Capture-MS Homo sapiens
118 KAT2B  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
119 ATXN7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
120 CD1B 910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 HNRNPM 4670
Affinity Capture-MS Homo sapiens
122 SIRT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 CDK1 983
Affinity Capture-Western Homo sapiens
124 KDM1A 23028
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
125 MOV10 4343
Affinity Capture-RNA Homo sapiens
126 EZH2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 FAM50A 9130
Affinity Capture-MS Homo sapiens
128 TADA2A  
Affinity Capture-MS Homo sapiens
129 UNC5CL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 ATXN7L3  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 AR 367
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
132 FXYD3 5349
Affinity Capture-MS Homo sapiens
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