Gene description for CTDSP1
Gene name CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
Gene symbol CTDSP1
Other names/aliases NIF3
NLI-IF
NLIIF
SCP1
Species Homo sapiens
 Database cross references - CTDSP1
ExoCarta ExoCarta_58190
Entrez Gene 58190
HGNC 21614
MIM 605323
UniProt Q9GZU7  
 CTDSP1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CTDSP1
Molecular Function
    CTD phosphatase activity GO:0008420 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of neuron differentiation GO:0045665 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IDA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IEA
    negative regulation of protein phosphorylation GO:0001933 IEA
    protein dephosphorylation GO:0006470 IDA
Subcellular Localization
    nucleus GO:0005634 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified CTDSP1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTDSP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2F1 2962
Affinity Capture-MS Homo sapiens
2 CDCA3 83461
Two-hybrid Homo sapiens
3 POLR2A 5430
Biochemical Activity Homo sapiens
4 LDB1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CTDSP1 is involved
No pathways found





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