Gene description for FANCL
Gene name Fanconi anemia, complementation group L
Gene symbol FANCL
Other names/aliases FAAP43
PHF9
POG
Species Homo sapiens
 Database cross references - FANCL
ExoCarta ExoCarta_55120
Vesiclepedia VP_55120
Entrez Gene 55120
HGNC 20748
MIM 608111
UniProt Q9NW38  
 FANCL identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for FANCL
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    ubiquitin-protein transferase activity GO:0004842 ISS
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    DNA repair GO:0006281 IBA
    DNA repair GO:0006281 IMP
    protein monoubiquitination GO:0006513 IBA
    protein monoubiquitination GO:0006513 IDA
    DNA damage response GO:0006974 IMP
    gamete generation GO:0007276 IEA
    interstrand cross-link repair GO:0036297 NAS
    regulation of cell population proliferation GO:0042127 IEA
Subcellular Localization
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nuclear envelope GO:0005635 IEA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
    nuclear body GO:0016604 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    Fanconi anaemia nuclear complex GO:0043240 IDA
    Fanconi anaemia nuclear complex GO:0043240 NAS
 Experiment description of studies that identified FANCL in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FANCL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Two-hybrid Homo sapiens
2 MORN3  
Two-hybrid Homo sapiens
3 FAM173A  
Two-hybrid Homo sapiens
4 UBE2W  
PCA Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
5 DDAH2 23564
Two-hybrid Homo sapiens
6 SNX7 51375
Affinity Capture-MS Homo sapiens
7 TFCP2 7024
Two-hybrid Homo sapiens
8 GRN 2896
Two-hybrid Homo sapiens
9 RBM45  
Two-hybrid Homo sapiens
10 RNF11 26994
Two-hybrid Homo sapiens
11 CTDSP1 58190
Two-hybrid Homo sapiens
12 FANCD2  
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
13 DOCK8 81704
Two-hybrid Homo sapiens
14 FANCC 2176
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 C19orf40  
Affinity Capture-Western Homo sapiens
16 KIFC3 3801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 CADPS  
Two-hybrid Homo sapiens
18 IKZF3  
Two-hybrid Homo sapiens
19 UFSP1  
Two-hybrid Homo sapiens
20 KRTAP19-6  
Two-hybrid Homo sapiens
21 C19orf54  
Two-hybrid Homo sapiens
22 VSIG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CLEC2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 FANCL 55120
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
25 STRA13  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 C1orf86  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 FANCB  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
28 UBE2T  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
29 FANCI 55215
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
30 ATRIP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
31 POLR2D  
Affinity Capture-MS Homo sapiens
32 CTBP1 1487
Two-hybrid Homo sapiens
33 CHCHD3 54927
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 HDHD3 81932
Two-hybrid Homo sapiens
35 SCNM1  
Two-hybrid Homo sapiens
36 HOXD4  
Two-hybrid Homo sapiens
37 PCNA 5111
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
38 FANCM 57697
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 LZTS2 84445
Two-hybrid Homo sapiens
40 PBRM1 55193
Negative Genetic Homo sapiens
41 FANCA  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
42 APITD1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
43 CYB5R2 51700
Two-hybrid Homo sapiens
44 FANCG 2189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
45 BAG6 7917
Affinity Capture-MS Homo sapiens
46 CCDC36  
Two-hybrid Homo sapiens
47 FANCF  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
48 SNX11 29916
Affinity Capture-MS Homo sapiens
49 KRTAP13-2  
Two-hybrid Homo sapiens
50 HES1 3280
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
51 C17orf70  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 GPR150  
Affinity Capture-MS Homo sapiens
53 RIMBP3 85376
Two-hybrid Homo sapiens
54 POLR2E 5434
Affinity Capture-MS Homo sapiens
55 PPP1R7 5510
Affinity Capture-MS Homo sapiens
56 CYCS 54205
Affinity Capture-MS Homo sapiens
57 EIF4ENIF1 56478
Two-hybrid Homo sapiens
58 Foxf1  
Affinity Capture-Western Mus musculus
59 SNF8 11267
Two-hybrid Homo sapiens
60 METTL15  
Two-hybrid Homo sapiens
61 KRTAP11-1  
Two-hybrid Homo sapiens
62 IL6R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CERCAM 51148
Two-hybrid Homo sapiens
64 ZNF581  
Two-hybrid Homo sapiens
65 ID2  
Two-hybrid Homo sapiens
66 SSX2IP  
Two-hybrid Homo sapiens
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