Gene description for PBRM1
Gene name polybromo 1
Gene symbol PBRM1
Other names/aliases BAF180
PB1
Species Homo sapiens
 Database cross references - PBRM1
ExoCarta ExoCarta_55193
Entrez Gene 55193
HGNC 30064
MIM 606083
UniProt Q86U86  
 PBRM1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PBRM1
Molecular Function
    DNA binding GO:0003677 IEA
    chromatin binding GO:0003682 NAS
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of cell proliferation GO:0008285 IMP
    placenta development GO:0001890 IEA
    chromatin remodeling GO:0006338 TAS
    heart development GO:0007507 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    mitotic nuclear division GO:0007067 TAS
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    BAF-type complex GO:0090544 IDA
    nuclear chromosome GO:0000228 NAS
    kinetochore GO:0000776 IEA
 Experiment description of studies that identified PBRM1 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PBRM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PBRM1 is involved
PathwayEvidenceSource
RMTs methylate histone arginines TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here