Gene description for PBRM1
Gene name polybromo 1
Gene symbol PBRM1
Other names/aliases BAF180
PB1
Species Homo sapiens
 Database cross references - PBRM1
ExoCarta ExoCarta_55193
Vesiclepedia VP_55193
Entrez Gene 55193
HGNC 30064
MIM 606083
UniProt Q86U86  
 PBRM1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for PBRM1
Molecular Function
    DNA binding GO:0003677 IEA
    chromatin binding GO:0003682 IBA
    chromatin binding GO:0003682 NAS
    protein binding GO:0005515 IPI
Biological Process
    mitotic cell cycle GO:0000278 TAS
    chromatin remodeling GO:0006338 IBA
    chromatin remodeling GO:0006338 NAS
    chromatin remodeling GO:0006338 TAS
    regulation of transcription by RNA polymerase II GO:0006357 NAS
    transcription elongation by RNA polymerase II GO:0006368 IBA
    negative regulation of cell population proliferation GO:0008285 IMP
    regulation of mitotic metaphase/anaphase transition GO:0030071 NAS
    positive regulation of T cell differentiation GO:0045582 NAS
    positive regulation of cell differentiation GO:0045597 NAS
    positive regulation of myoblast differentiation GO:0045663 NAS
    regulation of G0 to G1 transition GO:0070316 NAS
    regulation of G1/S transition of mitotic cell cycle GO:2000045 NAS
    positive regulation of double-strand break repair GO:2000781 NAS
    regulation of nucleotide-excision repair GO:2000819 NAS
Subcellular Localization
    nuclear chromosome GO:0000228 NAS
    kinetochore GO:0000776 NAS
    chromatin GO:0000785 NAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nuclear matrix GO:0016363 NAS
    SWI/SNF complex GO:0016514 IBA
    SWI/SNF complex GO:0016514 IDA
    RSC-type complex GO:0016586 IBA
    RSC-type complex GO:0016586 NAS
 Experiment description of studies that identified PBRM1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PBRM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL11 6135
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
3 SENP3 26168
Affinity Capture-MS Homo sapiens
4 ELF1 1997
Proximity Label-MS Homo sapiens
5 IRF4  
Proximity Label-MS Homo sapiens
6 GTF3C5 9328
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
7 FEV  
Proximity Label-MS Homo sapiens
8 KPNA1 3836
Affinity Capture-MS Homo sapiens
9 KLF9 687
Proximity Label-MS Homo sapiens
10 Bcl7b  
Affinity Capture-MS Mus musculus
11 LHX2  
Proximity Label-MS Homo sapiens
12 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
13 GATA2  
Proximity Label-MS Homo sapiens
14 SOX2  
Proximity Label-MS Homo sapiens
15 SMARCE1 6605
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
16 UBE3A 7337
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 BRD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 FANCF  
Negative Genetic Homo sapiens
19 KPNA2 3838
Affinity Capture-MS Homo sapiens
20 SYVN1 84447
Negative Genetic Homo sapiens
21 SMARCD2 6603
Affinity Capture-MS Homo sapiens
22 SOX10  
Proximity Label-MS Homo sapiens
23 GLTSCR1 29998
Affinity Capture-MS Homo sapiens
24 APP 351
Reconstituted Complex Homo sapiens
25 NUP160 23279
Negative Genetic Homo sapiens
26 CENPA  
Proximity Label-MS Homo sapiens
27 DPF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 APEX1 328
Proximity Label-MS Homo sapiens
29 DPPA4  
Affinity Capture-MS Homo sapiens
30 YPEL5 51646
Negative Genetic Homo sapiens
31 TOP2A 7153
Affinity Capture-MS Homo sapiens
32 RPL10A 4736
Affinity Capture-MS Homo sapiens
33 WDR76  
Affinity Capture-MS Homo sapiens
34 NDUFS3 4722
Negative Genetic Homo sapiens
35 BRD4 23476
Affinity Capture-MS Homo sapiens
36 C10orf105  
Negative Genetic Homo sapiens
37 KLF8  
Proximity Label-MS Homo sapiens
38 SDHB 6390
Negative Genetic Homo sapiens
39 PRC1 9055
Affinity Capture-MS Homo sapiens
40 NPM1 4869
Affinity Capture-MS Homo sapiens
41 ZNF512B  
Two-hybrid Homo sapiens
42 STK11IP 114790
Affinity Capture-MS Homo sapiens
43 KLF6  
Proximity Label-MS Homo sapiens
44 POLR1E  
Proximity Label-MS Homo sapiens
45 TNP2  
Affinity Capture-MS Homo sapiens
46 OBSL1 23363
Affinity Capture-MS Homo sapiens
47 HMGA1 3159
Affinity Capture-MS Homo sapiens
48 TEAD1  
Proximity Label-MS Homo sapiens
49 COIL  
Proximity Label-MS Homo sapiens
50 HIST2H2AC 8338
Protein-peptide Homo sapiens
51 ACER3  
Affinity Capture-MS Homo sapiens
52 GART 2618
Negative Genetic Homo sapiens
53 TULP2  
Negative Genetic Homo sapiens
54 BPTF 2186
Negative Genetic Homo sapiens
55 LHX4  
Proximity Label-MS Homo sapiens
56 TLX3  
Proximity Label-MS Homo sapiens
57 MTMR10 54893
Affinity Capture-MS Homo sapiens
58 KLF15  
Proximity Label-MS Homo sapiens
59 SMARCB1 6598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
60 SMARCA2 6595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 FANCD2  
Negative Genetic Homo sapiens
62 H2AFZ 3015
Affinity Capture-MS Homo sapiens
63 ZDHHC17 23390
Two-hybrid Homo sapiens
64 KLF5  
Proximity Label-MS Homo sapiens
65 PHF10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 SFR1 119392
Negative Genetic Homo sapiens
67 POLD1 5424
Affinity Capture-MS Homo sapiens
68 BRIP1  
Negative Genetic Homo sapiens
69 NUMA1 4926
Affinity Capture-MS Homo sapiens
70 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
71 SOX17  
Proximity Label-MS Homo sapiens
72 IRF1  
Proximity Label-MS Homo sapiens
73 ELK3  
Proximity Label-MS Homo sapiens
74 NFIX 4784
Proximity Label-MS Homo sapiens
75 ZBTB48  
Affinity Capture-MS Homo sapiens
76 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
77 SMARCA4 6597
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
78 LHX1  
Proximity Label-MS Homo sapiens
79 Srp72  
Affinity Capture-MS Mus musculus
80 BCL7C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 DPF2  
Affinity Capture-MS Homo sapiens
82 ACTL6A 86
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
83 LHX3  
Proximity Label-MS Homo sapiens
84 LHX8  
Proximity Label-MS Homo sapiens
85 PAX8  
Proximity Label-MS Homo sapiens
86 NFYC 4802
Proximity Label-MS Homo sapiens
87 COPS3 8533
Co-fractionation Homo sapiens
88 HECTD1 25831
Affinity Capture-MS Homo sapiens
89 RPLP0 6175
Affinity Capture-MS Homo sapiens
90 EED  
Affinity Capture-MS Homo sapiens
91 SS18L1  
Affinity Capture-MS Homo sapiens
92 PARD6B 84612
Negative Genetic Homo sapiens
93 KLF12  
Proximity Label-MS Homo sapiens
94 CARS 833
Cross-Linking-MS (XL-MS) Homo sapiens
95 RANGAP1 5905
Co-fractionation Homo sapiens
96 SMARCC2 6601
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
97 CD3EAP  
Proximity Label-MS Homo sapiens
98 SCARNA22  
Affinity Capture-RNA Homo sapiens
99 FGFBP1 9982
Affinity Capture-MS Homo sapiens
100 BRD7  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
101 TLX2  
Proximity Label-MS Homo sapiens
102 OR8B8  
Affinity Capture-MS Homo sapiens
103 PAX6  
Proximity Label-MS Homo sapiens
104 ZBTB2 57621
Affinity Capture-MS Homo sapiens
105 HIST1H3A 8350
Proximity Label-MS Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
106 LHX6  
Proximity Label-MS Homo sapiens
107 SMARCAD1  
Affinity Capture-MS Homo sapiens
108 CEACAM7  
Affinity Capture-MS Homo sapiens
109 SMARCD1 6602
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
110 TYMS 7298
Negative Genetic Homo sapiens
111 SIRT7  
Affinity Capture-MS Homo sapiens
112 PPARG 5468
Proximity Label-MS Homo sapiens
113 MAML1  
Affinity Capture-Western Homo sapiens
114 PRDX1 5052
Negative Genetic Homo sapiens
115 PDIA3 2923
Negative Genetic Homo sapiens
116 NR3C1 2908
Proximity Label-MS Homo sapiens
117 RPL3 6122
Affinity Capture-MS Homo sapiens
118 POU5F1  
Affinity Capture-MS Homo sapiens
119 YY1 7528
Proximity Label-MS Homo sapiens
120 H1F0 3005
Affinity Capture-MS Homo sapiens
121 ANP32E 81611
Affinity Capture-MS Homo sapiens
122 VHL  
Negative Genetic Homo sapiens
123 HIST3H3 8290
Affinity Capture-Luminescence Homo sapiens
124 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
125 ARID1B 57492
Affinity Capture-MS Homo sapiens
126 HNF4A  
Proximity Label-MS Homo sapiens
127 FANCA  
Negative Genetic Homo sapiens
128 GATA3  
Proximity Label-MS Homo sapiens
129 FOS 2353
Proximity Label-MS Homo sapiens
130 MYC  
Proximity Label-MS Homo sapiens
131 HECW2  
Affinity Capture-MS Homo sapiens
132 SNX17 9784
Negative Genetic Homo sapiens
133 AHR 196
Negative Genetic Homo sapiens
134 MAPKAP1 79109
Negative Genetic Homo sapiens
135 TOP1 7150
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
136 ETS1  
Proximity Label-MS Homo sapiens
137 ETV3  
Proximity Label-MS Homo sapiens
138 RANBP1 5902
Affinity Capture-MS Homo sapiens
139 ARID1A 8289
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
140 SOX9  
Proximity Label-MS Homo sapiens
141 NANOG  
Affinity Capture-MS Homo sapiens
142 BRD9 65980
Affinity Capture-MS Homo sapiens
143 BRD3 8019
Affinity Capture-MS Homo sapiens
144 ENTPD8  
Negative Genetic Homo sapiens
145 RPS16 6217
Affinity Capture-MS Homo sapiens
146 ELF4 2000
Proximity Label-MS Homo sapiens
147 CHD7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
148 FDCSP  
Affinity Capture-MS Homo sapiens
149 TLX1  
Proximity Label-MS Homo sapiens
150 RPL37 6167
Affinity Capture-MS Homo sapiens
151 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
152 FASN 2194
Positive Genetic Homo sapiens
153 CDC20 991
Affinity Capture-MS Homo sapiens
154 SIRT6  
Affinity Capture-MS Homo sapiens
155 PARP1 142
Affinity Capture-MS Homo sapiens
156 ARID2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
157 ELF5  
Proximity Label-MS Homo sapiens
158 TCHHL1  
Co-fractionation Homo sapiens
159 SOX15  
Proximity Label-MS Homo sapiens
160 SSRP1 6749
Affinity Capture-MS Homo sapiens
161 HDAC6 10013
Negative Genetic Homo sapiens
162 SMARCC1 6599
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
163 USP36  
Affinity Capture-MS Homo sapiens
164 FANCL 55120
Negative Genetic Homo sapiens
165 KLF3  
Proximity Label-MS Homo sapiens
166 SS18  
Affinity Capture-MS Homo sapiens
167 SOX4  
Proximity Label-MS Homo sapiens
168 CHD4 1108
Affinity Capture-MS Homo sapiens
169 PAX9  
Proximity Label-MS Homo sapiens
170 DDX19A 55308
Negative Genetic Homo sapiens
171 RGPD1  
Affinity Capture-MS Homo sapiens
172 TRIM25 7706
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
173 MYOD1  
Proximity Label-MS Homo sapiens
174 UBE2T  
Negative Genetic Homo sapiens
175 ELF3 1999
Proximity Label-MS Homo sapiens
176 DNAJA2 10294
Co-fractionation Homo sapiens
177 HACD2 201562
Affinity Capture-MS Homo sapiens
178 NUP50 10762
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
179 EZH2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
180 CALML5 51806
Affinity Capture-Western Homo sapiens
181 NDUFC1  
Negative Genetic Homo sapiens
182 DPF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
183 CHTF18 63922
Negative Genetic Homo sapiens
184 UMPS 7372
Negative Genetic Homo sapiens
185 HNF1B  
Proximity Label-MS Homo sapiens
186 SOX7  
Proximity Label-MS Homo sapiens
187 AR 367
Proximity Label-MS Homo sapiens
188 SMARCD3  
Affinity Capture-MS Homo sapiens
189 NUCKS1 64710
Affinity Capture-MS Homo sapiens
190 SP7  
Proximity Label-MS Homo sapiens
191 BCL7A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
192 NOTCH1 4851
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
193 LMO3  
Affinity Capture-MS Homo sapiens
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