Gene description for POLD1
Gene name polymerase (DNA directed), delta 1, catalytic subunit
Gene symbol POLD1
Other names/aliases CDC2
CRCS10
MDPL
POLD
Species Homo sapiens
 Database cross references - POLD1
ExoCarta ExoCarta_5424
Vesiclepedia VP_5424
Entrez Gene 5424
HGNC 9175
MIM 174761
UniProt P28340  
 POLD1 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for POLD1
Molecular Function
    nucleotide binding GO:0000166 IEA
    DNA binding GO:0003677 IDA
    chromatin binding GO:0003682 IDA
    damaged DNA binding GO:0003684 IDA
    DNA-directed DNA polymerase activity GO:0003887 IBA
    DNA-directed DNA polymerase activity GO:0003887 IMP
    protein binding GO:0005515 IPI
    3'-5'-DNA exonuclease activity GO:0008296 IBA
    enzyme binding GO:0019899 IEA
    metal ion binding GO:0046872 IEA
    4 iron, 4 sulfur cluster binding GO:0051539 IEA
Biological Process
    DNA synthesis involved in DNA repair GO:0000731 IDA
    DNA synthesis involved in DNA repair GO:0000731 IMP
    DNA replication GO:0006260 IMP
    DNA-templated DNA replication GO:0006261 IBA
    DNA-templated DNA replication GO:0006261 IDA
    DNA repair GO:0006281 TAS
    base-excision repair, gap-filling GO:0006287 IBA
    base-excision repair, gap-filling GO:0006287 IDA
    nucleotide-excision repair, DNA gap filling GO:0006297 IBA
    nucleotide-excision repair, DNA gap filling GO:0006297 IC
    nucleotide-excision repair, DNA gap filling GO:0006297 IMP
    response to UV GO:0009411 TAS
    cellular response to UV GO:0034644 IDA
    DNA replication proofreading GO:0045004 IBA
    fatty acid homeostasis GO:0055089 IMP
    error-free translesion synthesis GO:0070987 IDA
    DNA biosynthetic process GO:0071897 IDA
Subcellular Localization
    nucleotide-excision repair complex GO:0000109 IDA
    chromosome, telomeric region GO:0000781 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    membrane GO:0016020 HDA
    aggresome GO:0016235 IDA
    delta DNA polymerase complex GO:0043625 IBA
    delta DNA polymerase complex GO:0043625 IDA
    delta DNA polymerase complex GO:0043625 IPI
 Experiment description of studies that identified POLD1 in sEVs
1
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POLD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 ATR  
Protein-peptide Homo sapiens
3 KIF16B 55614
Affinity Capture-MS Homo sapiens
4 PRIM2 5558
Co-fractionation Homo sapiens
5 RIT1 6016
Negative Genetic Homo sapiens
6 MCM3 4172
Co-fractionation Homo sapiens
7 HBB 3043
Affinity Capture-MS Homo sapiens
8 PQBP1  
Affinity Capture-MS Homo sapiens
9 CAAP1  
Affinity Capture-MS Homo sapiens
10 FAM32A  
Affinity Capture-MS Homo sapiens
11 NCBP1 4686
Affinity Capture-MS Homo sapiens
12 SPRTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
13 USP43  
Affinity Capture-MS Homo sapiens
14 RAB1A 5861
Affinity Capture-MS Homo sapiens
15 YOD1  
Affinity Capture-MS Homo sapiens
16 TBC1D2 55357
Co-fractionation Homo sapiens
17 CIB2  
Affinity Capture-MS Homo sapiens
18 TBC1D4  
Co-fractionation Homo sapiens
19 WASF2 10163
Co-fractionation Homo sapiens
20 NOP14 8602
Affinity Capture-MS Homo sapiens
21 COPS6 10980
Affinity Capture-MS Homo sapiens
22 SLC25A13 10165
Affinity Capture-MS Homo sapiens
23 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
24 EIF2AK1  
Affinity Capture-MS Homo sapiens
25 TAF3 83860
Affinity Capture-MS Homo sapiens
26 NUP153 9972
Affinity Capture-MS Homo sapiens
27 DCTN2 10540
Affinity Capture-MS Homo sapiens
28 TERF2IP 54386
Two-hybrid Homo sapiens
29 HNRNPR 10236
Affinity Capture-MS Homo sapiens
30 ANKRD39  
Affinity Capture-MS Homo sapiens
31 CTNND1 1500
Affinity Capture-MS Homo sapiens
32 PRPF40A 55660
Affinity Capture-MS Homo sapiens
33 S100A14 57402
Affinity Capture-MS Homo sapiens
34 ZMAT2  
Affinity Capture-MS Homo sapiens
35 APEX1 328
Affinity Capture-RNA Homo sapiens
36 CAPZB 832
Affinity Capture-MS Homo sapiens
37 XRCC1 7515
Affinity Capture-Western Homo sapiens
38 TOP2A 7153
Affinity Capture-MS Homo sapiens
39 TRIM28 10155
Affinity Capture-MS Homo sapiens
40 RBM28 55131
Affinity Capture-MS Homo sapiens
41 PRC1 9055
Affinity Capture-MS Homo sapiens
42 ATAD3B 83858
Affinity Capture-MS Homo sapiens
43 SPECC1L 23384
Affinity Capture-MS Homo sapiens
44 NOLC1 9221
Affinity Capture-MS Homo sapiens
45 PPP2R5C 5527
Co-fractionation Homo sapiens
46 D2HGDH 728294
Affinity Capture-MS Homo sapiens
47 RFXANK  
Affinity Capture-MS Homo sapiens
48 SMARCA1 6594
Affinity Capture-MS Homo sapiens
49 HES6  
Affinity Capture-MS Homo sapiens
50 LIG1 3978
Co-fractionation Homo sapiens
51 COPS5 10987
Affinity Capture-MS Homo sapiens
52 FBXW7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
53 CEP192 55125
Affinity Capture-MS Homo sapiens
54 DUSP11  
Affinity Capture-MS Homo sapiens
55 PRIM1  
Co-fractionation Homo sapiens
56 SRRM2 23524
Affinity Capture-MS Homo sapiens
57 HSPH1 10808
Affinity Capture-MS Homo sapiens
58 LSG1  
Affinity Capture-MS Homo sapiens
59 SLC31A1 1317
Affinity Capture-MS Homo sapiens
60 OBSL1 23363
Affinity Capture-MS Homo sapiens
61 PRPS1 5631
Affinity Capture-MS Homo sapiens
62 MYH7 4625
Affinity Capture-MS Homo sapiens
63 LRRC61 65999
Proximity Label-MS Homo sapiens
64 POLRMT 5442
Affinity Capture-MS Homo sapiens
65 ZNF326 284695
Affinity Capture-MS Homo sapiens
66 ADRBK2  
Affinity Capture-MS Homo sapiens
67 CHGB 1114
Two-hybrid Homo sapiens
68 ATRX 546
Affinity Capture-MS Homo sapiens
69 ATG7 10533
Affinity Capture-MS Homo sapiens
70 ABT1 29777
Affinity Capture-MS Homo sapiens
71 DNAJC7 7266
Proximity Label-MS Homo sapiens
72 ATG16L1 55054
Affinity Capture-MS Homo sapiens
73 SFN 2810
Affinity Capture-MS Homo sapiens
74 LYN 4067
Affinity Capture-MS Homo sapiens
75 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 NPAS1  
Affinity Capture-MS Homo sapiens
77 PLS3 5358
Affinity Capture-MS Homo sapiens
78 SLU7  
Affinity Capture-MS Homo sapiens
79 FBXW5  
Affinity Capture-MS Homo sapiens
80 RBM14 10432
Affinity Capture-MS Homo sapiens
81 GAR1 54433
Affinity Capture-MS Homo sapiens
82 MAPK8IP2  
Affinity Capture-MS Homo sapiens
83 MRPS34 65993
Affinity Capture-MS Homo sapiens
84 BAZ1B 9031
Affinity Capture-MS Homo sapiens
85 CHD1 1105
Affinity Capture-MS Homo sapiens
86 BRIX1 55299
Affinity Capture-MS Homo sapiens
87 C1QBP 708
Affinity Capture-MS Homo sapiens
88 FARSA 2193
Affinity Capture-MS Homo sapiens
89 PRPF6 24148
Affinity Capture-MS Homo sapiens
90 PCNT  
Affinity Capture-MS Homo sapiens
91 FAM96A  
Affinity Capture-MS Homo sapiens
92 POLD1 5424
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 SYMPK 8189
Affinity Capture-MS Homo sapiens
94 BAG2 9532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 CNOT2  
Affinity Capture-MS Homo sapiens
96 ITPR1 3708
Affinity Capture-MS Homo sapiens
97 VCL 7414
Affinity Capture-MS Homo sapiens
98 PARK2  
Affinity Capture-MS Homo sapiens
99 PGAM5 192111
Affinity Capture-MS Homo sapiens
100 KLHL34  
Affinity Capture-MS Homo sapiens
101 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
102 HSP90B1 7184
Affinity Capture-MS Homo sapiens
103 FAM96B 51647
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
104 CCT5 22948
Affinity Capture-MS Homo sapiens
105 PRPS2 5634
Affinity Capture-MS Homo sapiens
106 POLA2  
Co-fractionation Homo sapiens
107 ABCF2 10061
Affinity Capture-MS Homo sapiens
108 PTP4A3  
Affinity Capture-MS Homo sapiens
109 DDX20 11218
Affinity Capture-MS Homo sapiens
110 CCNB1 891
Co-fractionation Homo sapiens
111 CHMP4B 128866
Affinity Capture-MS Homo sapiens
112 GRAMD4 23151
Affinity Capture-MS Homo sapiens
113 RPA2 6118
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
114 VCP 7415
Affinity Capture-MS Homo sapiens
115 DDX5 1655
Affinity Capture-MS Homo sapiens
116 NTRK1 4914
Affinity Capture-MS Homo sapiens
117 GGH 8836
Affinity Capture-MS Homo sapiens
118 TPI1 7167
Affinity Capture-MS Homo sapiens
119 MRPL48  
Affinity Capture-MS Homo sapiens
120 PPARD  
Affinity Capture-MS Homo sapiens
121 NUP62 23636
Affinity Capture-MS Homo sapiens
122 TRIP10 9322
Co-fractionation Homo sapiens
123 POLD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 NSRP1  
Affinity Capture-MS Homo sapiens
125 GINS4  
Reconstituted Complex Homo sapiens
126 S100B 6285
Affinity Capture-MS Homo sapiens
127 ACTB 60
Affinity Capture-MS Homo sapiens
128 ACTR5 79913
Affinity Capture-MS Homo sapiens
129 Pcna 18538
Affinity Capture-MS Mus musculus
130 DHX9 1660
Affinity Capture-Western Homo sapiens
131 GNAI2 2771
Affinity Capture-MS Homo sapiens
132 AP3B1 8546
Affinity Capture-MS Homo sapiens
133 POLE  
Co-fractionation Homo sapiens
134 NKAP 79576
Affinity Capture-MS Homo sapiens
135 CAPN1 823
Affinity Capture-MS Homo sapiens
136 MAX  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
137 NUDC 10726
Affinity Capture-MS Homo sapiens
138 HSPB8 26353
Affinity Capture-MS Homo sapiens
139 TAF13  
Affinity Capture-MS Homo sapiens
140 UBXN6 80700
Affinity Capture-MS Homo sapiens
141 PURB 5814
Co-fractionation Homo sapiens
142 CDK4 1019
Biochemical Activity Homo sapiens
143 SNRPB2 6629
Affinity Capture-MS Homo sapiens
144 PSG11  
Affinity Capture-MS Homo sapiens
145 TPR 7175
Affinity Capture-MS Homo sapiens
146 RTCB 51493
Affinity Capture-MS Homo sapiens
147 CBX4  
Affinity Capture-MS Homo sapiens
148 CT45A10  
Affinity Capture-MS Homo sapiens
149 TUBB 203068
Affinity Capture-MS Homo sapiens
150 CCNA2 890
Co-fractionation Homo sapiens
151 USP42  
Affinity Capture-MS Homo sapiens
152 AIFM1 9131
Affinity Capture-MS Homo sapiens
153 UPF1 5976
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
154 CIAO1 9391
Affinity Capture-MS Homo sapiens
155 XPO1 7514
Affinity Capture-MS Homo sapiens
156 WRNIP1 56897
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
157 ZBTB24  
Affinity Capture-MS Homo sapiens
158 PNN 5411
Affinity Capture-MS Homo sapiens
159 NOC4L 79050
Affinity Capture-MS Homo sapiens
160 POLD3  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
161 AHNAK 79026
Affinity Capture-MS Homo sapiens
162 POLK  
Affinity Capture-Western Homo sapiens
163 CD6 923
Affinity Capture-MS Homo sapiens
164 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 MRPS23 51649
Affinity Capture-MS Homo sapiens
166 CCNE1  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
167 KIAA1377  
Two-hybrid Homo sapiens
168 METTL21B  
Affinity Capture-MS Homo sapiens
169 HNRNPUL1 11100
Affinity Capture-MS Homo sapiens
170 RNF126  
Affinity Capture-MS Homo sapiens
171 RBBP4 5928
Affinity Capture-MS Homo sapiens
172 PPP2CA 5515
Affinity Capture-MS Homo sapiens
173 RFC1 5981
Co-fractionation Homo sapiens
174 RP9  
Affinity Capture-MS Homo sapiens
175 TRIM55  
Two-hybrid Homo sapiens
176 AURKB 9212
Affinity Capture-MS Homo sapiens
177 TBC1D5 9779
Affinity Capture-MS Homo sapiens
178 CRYBB3  
Affinity Capture-MS Homo sapiens
179 FKBP5 2289
Affinity Capture-MS Homo sapiens
180 MAPK6  
Affinity Capture-MS Homo sapiens
181 MYL6B 140465
Affinity Capture-MS Homo sapiens
182 C12orf74  
Affinity Capture-MS Homo sapiens
183 MFAP1  
Affinity Capture-MS Homo sapiens
184 CRTC3  
Affinity Capture-MS Homo sapiens
185 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Co-localization Homo sapiens
186 DNAI2  
Affinity Capture-MS Homo sapiens
187 CD59 966
Affinity Capture-MS Homo sapiens
188 ARRDC3 57561
Affinity Capture-MS Homo sapiens
189 CCT8 10694
Affinity Capture-MS Homo sapiens
190 TOP1 7150
Co-fractionation Homo sapiens
191 DDB1 1642
Affinity Capture-MS Homo sapiens
192 UPF3B 65109
Affinity Capture-MS Homo sapiens
193 RNF2  
Affinity Capture-MS Homo sapiens
194 SF3B3 23450
Affinity Capture-MS Homo sapiens
195 WDR44 54521
Co-fractionation Homo sapiens
196 NAF1  
Affinity Capture-MS Homo sapiens
197 UPF2 26019
Affinity Capture-Western Homo sapiens
198 ECM1 1893
Affinity Capture-MS Homo sapiens
199 FLOT1 10211
Affinity Capture-MS Homo sapiens
200 NCAPG 64151
Affinity Capture-Western Homo sapiens
201 TPM3 7170
Affinity Capture-MS Homo sapiens
202 ZRANB1 54764
Affinity Capture-MS Homo sapiens
203 TFG 10342
Affinity Capture-MS Homo sapiens
204 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
205 TERF2  
Affinity Capture-MS Homo sapiens
206 PARP1 142
Co-fractionation Homo sapiens
207 NUP205 23165
Affinity Capture-MS Homo sapiens
208 ARID2  
Affinity Capture-MS Homo sapiens
209 SSFA2 6744
Affinity Capture-MS Homo sapiens
210 TP53 7157
Affinity Capture-MS Homo sapiens
211 MCM7 4176
Affinity Capture-MS Homo sapiens
212 HSPA8 3312
Affinity Capture-MS Homo sapiens
213 RUVBL2 10856
Affinity Capture-MS Homo sapiens
214 TBP  
Affinity Capture-MS Homo sapiens
215 DNAJA2 10294
Affinity Capture-MS Homo sapiens
216 ZNF746  
Affinity Capture-MS Homo sapiens
217 SRSF9 8683
Affinity Capture-MS Homo sapiens
218 CKB 1152
Affinity Capture-MS Homo sapiens
219 RPA1 6117
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
220 POLE3  
Co-fractionation Homo sapiens
221 GFOD1  
Affinity Capture-MS Homo sapiens
222 SKP1 6500
Affinity Capture-MS Homo sapiens
223 PIDD1  
Affinity Capture-MS Homo sapiens
224 PBRM1 55193
Affinity Capture-MS Homo sapiens
225 TSEN2  
Co-fractionation Homo sapiens
226 HSPB1 3315
Affinity Capture-MS Homo sapiens
227 CDK2 1017
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
228 MAGOH 4116
Affinity Capture-MS Homo sapiens
229 GNB1 2782
Affinity Capture-MS Homo sapiens
230 MKI67  
Affinity Capture-MS Homo sapiens
231 CDK1 983
Co-fractionation Homo sapiens
232 KIRREL 55243
Affinity Capture-MS Homo sapiens
233 PCNA 5111
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
234 UFL1 23376
Affinity Capture-MS Homo sapiens
235 ERCC6  
Affinity Capture-Western Homo sapiens
236 NUP107 57122
Affinity Capture-MS Homo sapiens
237 ACTA1 58
Affinity Capture-MS Homo sapiens
238 DHX16 8449
Affinity Capture-MS Homo sapiens
239 MMS19 64210
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
240 TAGLN2 8407
Affinity Capture-MS Homo sapiens
241 INF2 64423
Affinity Capture-MS Homo sapiens
242 ARHGAP25  
Affinity Capture-MS Homo sapiens
243 CAD 790
Affinity Capture-MS Homo sapiens
244 EAF1  
Affinity Capture-MS Homo sapiens
245 MYO1E 4643
Affinity Capture-MS Homo sapiens
246 HNRNPA1L2 144983
Affinity Capture-MS Homo sapiens
247 METTL3  
Affinity Capture-MS Homo sapiens
248 BRD1 23774
Affinity Capture-MS Homo sapiens
249 POLA1  
Co-fractionation Homo sapiens
250 GLRX3 10539
Affinity Capture-MS Homo sapiens
251 KRT23  
Affinity Capture-MS Homo sapiens
252 SNW1 22938
Affinity Capture-MS Homo sapiens
253 KRAS 3845
Negative Genetic Homo sapiens
254 C9orf72  
Affinity Capture-MS Homo sapiens
255 AR 367
Affinity Capture-MS Homo sapiens
256 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
257 MRPL28 10573
Affinity Capture-MS Homo sapiens
258 RPA3 6119
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
259 RBCK1  
Affinity Capture-MS Homo sapiens
260 POLD2 5425
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
261 RANBP2 5903
Affinity Capture-MS Homo sapiens
262 MGMT 4255
Affinity Capture-Western Homo sapiens
263 CDC5L 988
Affinity Capture-MS Homo sapiens
264 TCP1 6950
Affinity Capture-MS Homo sapiens
265 CCND3  
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which POLD1 is involved
PathwayEvidenceSource
Base Excision Repair TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Chromosome Maintenance TAS Reactome
Cytosolic iron-sulfur cluster assembly IEA Reactome
DNA Damage Bypass TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA Repair TAS Reactome
DNA Replication TAS Reactome
DNA strand elongation TAS Reactome
Dual Incision in GG-NER TAS Reactome
Dual incision in TC-NER TAS Reactome
Extension of Telomeres TAS Reactome
Gap-filling DNA repair synthesis and ligation in GG-NER TAS Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER TAS Reactome
Global Genome Nucleotide Excision Repair (GG-NER) TAS Reactome
HDR through Homologous Recombination (HRR) TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Lagging Strand Synthesis TAS Reactome
Leading Strand Synthesis TAS Reactome
Metabolism IEA Reactome
Mismatch Repair TAS Reactome
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) TAS Reactome
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) TAS Reactome
Nucleotide Excision Repair TAS Reactome
PCNA-Dependent Long Patch Base Excision Repair TAS Reactome
Polymerase switching TAS Reactome
Polymerase switching on the C-strand of the telomere TAS Reactome
Processive synthesis on the C-strand of the telomere TAS Reactome
Processive synthesis on the lagging strand TAS Reactome
Recognition of DNA damage by PCNA-containing replication complex TAS Reactome
Removal of the Flap Intermediate TAS Reactome
Removal of the Flap Intermediate from the C-strand TAS Reactome
Resolution of Abasic Sites (AP sites) TAS Reactome
Resolution of AP sites via the multiple-nucleotide patch replacement pathway TAS Reactome
S Phase TAS Reactome
Synthesis of DNA TAS Reactome
Telomere C-strand (Lagging Strand) Synthesis TAS Reactome
Telomere Maintenance TAS Reactome
Termination of translesion DNA synthesis TAS Reactome
Transcription-Coupled Nucleotide Excision Repair (TC-NER) TAS Reactome
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template TAS Reactome





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