Gene description for CHGB
Gene name chromogranin B
Gene symbol CHGB
Other names/aliases SCG1
Species Homo sapiens
 Database cross references - CHGB
ExoCarta ExoCarta_1114
Vesiclepedia VP_1114
Entrez Gene 1114
HGNC 1930
MIM 118920
UniProt P05060  
 CHGB identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CHGB
Molecular Function
    hormone activity GO:0005179 TAS
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    endoplasmic reticulum lumen GO:0005788 TAS
    secretory granule GO:0030141 IBA
    secretory granule GO:0030141 ISS
 Experiment description of studies that identified CHGB in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CHGB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CBFB 865
Two-hybrid Homo sapiens
2 MARK3 4140
Two-hybrid Homo sapiens
3 PKN2 5586
Two-hybrid Homo sapiens
4 MYCN  
Affinity Capture-MS Homo sapiens
5 TWF2 11344
Two-hybrid Homo sapiens
6 SLC25A6 293
Two-hybrid Homo sapiens
7 TUBB2A 7280
Two-hybrid Homo sapiens
8 TK1 7083
Two-hybrid Homo sapiens
9 MGLL 11343
Two-hybrid Homo sapiens
10 PRNP 5621
Affinity Capture-MS Homo sapiens
11 ATXN2 6311
Two-hybrid Homo sapiens
12 TAZ  
Two-hybrid Homo sapiens
13 ANXA7 310
Two-hybrid Homo sapiens
14 POLD1 5424
Two-hybrid Homo sapiens
15 SKP2  
Affinity Capture-MS Homo sapiens
16 PTEN 5728
Two-hybrid Homo sapiens
17 YLPM1 56252
Two-hybrid Homo sapiens
18 CDKN1A  
Two-hybrid Homo sapiens
19 PARK2  
Affinity Capture-MS Homo sapiens
20 ACACA 31
Two-hybrid Homo sapiens
21 APP 351
Reconstituted Complex Homo sapiens
22 FGFR3 2261
Two-hybrid Homo sapiens
23 OGG1  
Two-hybrid Homo sapiens
24 RAP1B 5908
Two-hybrid Homo sapiens
25 SAFB2 9667
Two-hybrid Homo sapiens
26 LRRK2 120892
Reconstituted Complex Homo sapiens
27 SGK223  
Two-hybrid Homo sapiens
28 S100A8 6279
Two-hybrid Homo sapiens
29 MOGS 7841
Two-hybrid Homo sapiens
30 CCDC92  
Two-hybrid Homo sapiens
31 UBQLN1 29979
Two-hybrid Homo sapiens
32 RAC2 5880
Two-hybrid Homo sapiens
33 RCC1 1104
Two-hybrid Homo sapiens
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