Gene description for SAFB2
Gene name scaffold attachment factor B2
Gene symbol SAFB2
Other names/aliases -
Species Homo sapiens
 Database cross references - SAFB2
ExoCarta ExoCarta_9667
Vesiclepedia VP_9667
Entrez Gene 9667
HGNC 21605
MIM 608066
UniProt Q14151  
 SAFB2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SAFB2
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    sequence-specific DNA binding GO:0043565 IBA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of mRNA processing GO:0050684 IBA
    Sertoli cell differentiation GO:0060008 IEA
    regulation of androgen receptor signaling pathway GO:0060765 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IEA
    nuclear body GO:0016604 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SAFB2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SAFB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCAR1 55749
Co-fractionation Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 HNRNPC 3183
Affinity Capture-MS Homo sapiens
5 PPP1CB 5500
Affinity Capture-MS Homo sapiens
6 ZNF514  
Affinity Capture-MS Homo sapiens
7 Fus  
Affinity Capture-MS Mus musculus
8 COX15 1355
Affinity Capture-MS Homo sapiens
9 IPO7 10527
Affinity Capture-MS Homo sapiens
10 GIT2 9815
Two-hybrid Homo sapiens
11 NUP62 23636
Cross-Linking-MS (XL-MS) Homo sapiens
12 ANAPC15  
Affinity Capture-MS Homo sapiens
13 KIF20A 10112
Affinity Capture-MS Homo sapiens
14 SSB 6741
Co-fractionation Homo sapiens
15 CAND1 55832
Affinity Capture-MS Homo sapiens
16 ANKRD50 57182
Affinity Capture-MS Homo sapiens
17 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
18 PPP1CC 5501
Affinity Capture-MS Homo sapiens
19 SAFB 6294
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
20 DDX23 9416
Proximity Label-MS Homo sapiens
21 HDAC3 8841
Affinity Capture-Western Homo sapiens
22 NCOR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 DYRK1A 1859
Affinity Capture-MS Homo sapiens
24 KIF23 9493
Affinity Capture-MS Homo sapiens
25 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
26 COPS5 10987
Affinity Capture-MS Homo sapiens
27 PRC1 9055
Affinity Capture-MS Homo sapiens
28 PSMD12 5718
Affinity Capture-MS Homo sapiens
29 SNRPC 6631
Affinity Capture-MS Homo sapiens
30 OBSL1 23363
Affinity Capture-MS Homo sapiens
31 EZH1  
Affinity Capture-MS Homo sapiens
32 HMGA1 3159
Affinity Capture-MS Homo sapiens
33 PEA15 8682
Affinity Capture-MS Homo sapiens
34 Taf15  
Affinity Capture-MS Mus musculus
35 EED  
Affinity Capture-MS Homo sapiens
36 ATG16L1 55054
Affinity Capture-MS Homo sapiens
37 KLHL20  
Affinity Capture-MS Homo sapiens
38 ZSCAN18  
Two-hybrid Homo sapiens
39 MECP2 4204
Affinity Capture-MS Homo sapiens
40 MYCN  
Affinity Capture-MS Homo sapiens
41 RBM14 10432
Affinity Capture-MS Homo sapiens
42 KIF14 9928
Affinity Capture-MS Homo sapiens
43 EMC9  
Affinity Capture-MS Homo sapiens
44 RBMX 27316
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CHMP4C 92421
Affinity Capture-MS Homo sapiens
46 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
47 DDX21 9188
Affinity Capture-MS Homo sapiens
48 RB1CC1 9821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 SUPT5H 6829
Affinity Capture-MS Homo sapiens
50 MEX3C 51320
Affinity Capture-MS Homo sapiens
51 PSMD14 10213
Affinity Capture-MS Homo sapiens
52 IFI27L1  
Affinity Capture-MS Homo sapiens
53 CHMP4B 128866
Affinity Capture-MS Homo sapiens
54 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 AIM2  
Affinity Capture-MS Homo sapiens
56 IFI16 3428
Affinity Capture-MS Homo sapiens
57 RAD18  
Affinity Capture-MS Homo sapiens
58 PNMA2  
Affinity Capture-MS Homo sapiens
59 CAMKK1  
Affinity Capture-MS Homo sapiens
60 RPA4  
Proximity Label-MS Homo sapiens
61 HECTD1 25831
Affinity Capture-MS Homo sapiens
62 PHACTR2  
Cross-Linking-MS (XL-MS) Homo sapiens
63 CEBPA  
Protein-peptide Homo sapiens
64 POLR2B 5431
Co-fractionation Homo sapiens
65 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 TPX2  
Affinity Capture-MS Homo sapiens
67 RNF40 9810
Affinity Capture-MS Homo sapiens
68 ZBTB2 57621
Affinity Capture-MS Homo sapiens
69 RBM39 9584
Affinity Capture-MS Homo sapiens
70 CHGB 1114
Two-hybrid Homo sapiens
71 FANCD2  
Affinity Capture-MS Homo sapiens
72 CLK3  
Affinity Capture-MS Homo sapiens
73 JPH3 57338
Affinity Capture-MS Homo sapiens
74 PSENEN  
Affinity Capture-MS Homo sapiens
75 SNRPB 6628
Affinity Capture-MS Homo sapiens
76 TRIP6 7205
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 SIRPA 140885
Reconstituted Complex Homo sapiens
78 CUL3 8452
Affinity Capture-MS Homo sapiens
79 FNTA 2339
Two-hybrid Homo sapiens
80 FUS 2521
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
81 HNRNPUL1 11100
Co-fractionation Homo sapiens
82 ZC3H11A  
Affinity Capture-MS Homo sapiens
83 SUZ12  
Affinity Capture-MS Homo sapiens
84 MYO1C 4641
Affinity Capture-MS Homo sapiens
85 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
86 MYC  
Affinity Capture-MS Homo sapiens
87 RPA3 6119
Proximity Label-MS Homo sapiens
88 Hnrnpa3 229279
Affinity Capture-MS Mus musculus
89 EMC2 9694
Affinity Capture-MS Homo sapiens
90 PABPC5 140886
Affinity Capture-MS Homo sapiens
91 DHPS 1725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 TOP1 7150
Affinity Capture-MS Homo sapiens
93 SORBS3 10174
Affinity Capture-Western Homo sapiens
94 MATR3 9782
Affinity Capture-MS Homo sapiens
95 DPM2 8818
Affinity Capture-MS Homo sapiens
96 BMI1  
Affinity Capture-MS Homo sapiens
97 VDAC1 7416
Affinity Capture-MS Homo sapiens
98 TMSB4Y  
Affinity Capture-MS Homo sapiens
99 RBM33  
Affinity Capture-MS Homo sapiens
100 PYHIN1  
Affinity Capture-MS Homo sapiens
101 MALL  
Affinity Capture-MS Homo sapiens
102 ZRANB1 54764
Affinity Capture-MS Homo sapiens
103 FNDC4 64838
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
105 CPSF6 11052
Affinity Capture-MS Homo sapiens
106 TP53 7157
Affinity Capture-Western Homo sapiens
107 APOBEC3D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 ATG13 9776
Affinity Capture-MS Homo sapiens
109 SAA1 6288
Affinity Capture-MS Homo sapiens
110 MEN1 4221
Affinity Capture-MS Homo sapiens
111 SNRPA 6626
Affinity Capture-MS Homo sapiens
112 NHLRC2 374354
Affinity Capture-MS Homo sapiens
113 ATG101  
Affinity Capture-MS Homo sapiens
114 CAPN13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 BIVM  
Cross-Linking-MS (XL-MS) Homo sapiens
116 E2F4  
Affinity Capture-MS Homo sapiens
117 LSS 4047
Affinity Capture-MS Homo sapiens
118 DDX58 23586
Affinity Capture-RNA Homo sapiens
119 RSPH9  
Affinity Capture-MS Homo sapiens
120 ESR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
121 Nup214  
Affinity Capture-MS Mus musculus
122 C20orf197  
Affinity Capture-MS Homo sapiens
123 Srsf1 110809
Affinity Capture-MS Mus musculus
124 MAP1LC3A 84557
Affinity Capture-MS Homo sapiens
125 IK 3550
Co-fractionation Homo sapiens
126 MOV10 4343
Affinity Capture-RNA Homo sapiens
127 EZH2  
Affinity Capture-MS Homo sapiens
128 SPCS1 28972
Affinity Capture-MS Homo sapiens
129 SRCAP  
Co-fractionation Homo sapiens
130 RPS6 6194
Affinity Capture-MS Homo sapiens
131 EP300 2033
Affinity Capture-MS Homo sapiens
132 TOPORS  
Affinity Capture-MS Homo sapiens
133 EHHADH 1962
Affinity Capture-MS Homo sapiens
134 CUL7 9820
Affinity Capture-MS Homo sapiens
135 CIZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 SSRP1 6749
Affinity Capture-MS Homo sapiens
137 UQCR11  
Affinity Capture-MS Homo sapiens
138 ZNF677  
Affinity Capture-MS Homo sapiens
139 APOA1 335
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SAFB2 is involved
No pathways found





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