Gene description for SAA1
Gene name serum amyloid A1
Gene symbol SAA1
Other names/aliases PIG4
SAA
SAA2
TP53I4
Species Homo sapiens
 Database cross references - SAA1
ExoCarta ExoCarta_6288
Vesiclepedia VP_6288
Entrez Gene 6288
HGNC 10513
MIM 104750
UniProt P0DJI8  
 SAA1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 22723089    
Saliva 19199708    
 Gene ontology annotations for SAA1
Molecular Function
    heparin binding GO:0008201 IEA
    G-protein coupled receptor binding GO:0001664 IDA
    chemoattractant activity GO:0042056 IBA
Biological Process
    negative regulation of inflammatory response GO:0050728 NAS
    positive regulation of cytosolic calcium ion concentration GO:0007204 NAS
    receptor-mediated endocytosis GO:0006898 TAS
    acute-phase response GO:0006953 NAS
    innate immune response GO:0045087 TAS
    lymphocyte chemotaxis GO:0048247 IDA
    positive regulation of cytokine secretion GO:0050715 IDA
    platelet activation GO:0030168 NAS
    macrophage chemotaxis GO:0048246 IDA
    positive chemotaxis GO:0050918 IBA
    neutrophil chemotaxis GO:0030593 NAS
    positive regulation of interleukin-1 secretion GO:0050716 NAS
    positive regulation of cell adhesion GO:0045785 NAS
    regulation of protein secretion GO:0050708 NAS
    activation of MAPK activity GO:0000187 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    high-density lipoprotein particle GO:0034364 IEA
    cytoplasmic microtubule GO:0005881 IDA
    cytosol GO:0005829 NAS
    endocytic vesicle lumen GO:0071682 TAS
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified SAA1 in exosomes
1
Experiment ID 146
MISEV standards
EM
EV Biophysical techniques
HSP70|HSP90|CD9
EV Enriched markers
HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
2
Experiment ID 66
MISEV standards
IEM
EV Biophysical techniques
TSG101|Alix|CD63|CD81
EV Enriched markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for SAA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VIMP 55829
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here