Gene description for PRRC2A
Gene name proline-rich coiled-coil 2A
Gene symbol PRRC2A
Other names/aliases BAT2
D6S51
D6S51E
G2
Species Homo sapiens
 Database cross references - PRRC2A
ExoCarta ExoCarta_7916
Vesiclepedia VP_7916
Entrez Gene 7916
HGNC 13918
MIM 142580
UniProt P48634  
 PRRC2A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for PRRC2A
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    cell differentiation GO:0030154 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 HDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PRRC2A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PRRC2A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNL2 29889
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 SRP19 6728
Affinity Capture-MS Homo sapiens
4 MAN2C1 4123
Two-hybrid Homo sapiens
5 H2AFJ 55766
Affinity Capture-MS Homo sapiens
6 PRM2  
Affinity Capture-MS Homo sapiens
7 ZNF24  
Affinity Capture-MS Homo sapiens
8 LGR4 55366
Affinity Capture-MS Homo sapiens
9 QARS 5859
Two-hybrid Homo sapiens
10 CLEC3A  
Affinity Capture-MS Homo sapiens
11 EIF2S3 1968
Affinity Capture-MS Homo sapiens
12 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
13 CDC14A  
Proximity Label-MS Homo sapiens
14 TARDBP 23435
Affinity Capture-MS Homo sapiens
15 FMR1 2332
Affinity Capture-MS Homo sapiens
16 RPA2 6118
Affinity Capture-MS Homo sapiens
17 P4HA2 8974
Two-hybrid Homo sapiens
18 FGFBP1 9982
Affinity Capture-MS Homo sapiens
19 ANAPC15  
Affinity Capture-MS Homo sapiens
20 FUOM  
Affinity Capture-MS Homo sapiens
21 CELA1  
Affinity Capture-MS Homo sapiens
22 NOP56 10528
Affinity Capture-MS Homo sapiens
23 IFI6  
Affinity Capture-MS Homo sapiens
24 KIF20A 10112
Affinity Capture-MS Homo sapiens
25 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
26 EIF4A1 1973
Affinity Capture-MS Homo sapiens
27 CAND1 55832
Affinity Capture-MS Homo sapiens
28 ATN1  
Two-hybrid Homo sapiens
29 TEKT3 64518
Affinity Capture-MS Homo sapiens
30 ANKRD50 57182
Affinity Capture-MS Homo sapiens
31 APEX1 328
Affinity Capture-RNA Homo sapiens
32 TMA16  
Affinity Capture-MS Homo sapiens
33 CAPZB 832
Affinity Capture-MS Homo sapiens
34 RPL4 6124
Affinity Capture-MS Homo sapiens
35 RPS20 6224
Proximity Label-MS Homo sapiens
36 SNRNP70 6625
Affinity Capture-MS Homo sapiens
37 YWHAZ 7534
Affinity Capture-MS Homo sapiens
38 EXOSC2 23404
Affinity Capture-MS Homo sapiens
39 KLF8  
Affinity Capture-MS Homo sapiens
40 IFT88 8100
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 EIF3B 8662
Affinity Capture-MS Homo sapiens
42 METAP2 10988
Affinity Capture-MS Homo sapiens
43 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
44 COL8A1 1295
Affinity Capture-MS Homo sapiens
45 CHCHD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FBL 2091
Proximity Label-MS Homo sapiens
47 CALCOCO2  
Affinity Capture-MS Homo sapiens
48 KLF15  
Affinity Capture-MS Homo sapiens
49 LINC00240  
Affinity Capture-MS Homo sapiens
50 EWSR1 2130
Two-hybrid Homo sapiens
51 GSPT1 2935
Affinity Capture-MS Homo sapiens
52 PEA15 8682
Affinity Capture-MS Homo sapiens
53 EIF3E 3646
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 NPM1 4869
Affinity Capture-MS Homo sapiens
55 MAD2L2 10459
Two-hybrid Homo sapiens
56 SRP68 6730
Affinity Capture-MS Homo sapiens
57 KIF2C 11004
Affinity Capture-MS Homo sapiens
58 ATG16L1 55054
Affinity Capture-MS Homo sapiens
59 DDX6 1656
Affinity Capture-MS Homo sapiens
60 SERF2 10169
Affinity Capture-MS Homo sapiens
61 Eif3a 13669
Affinity Capture-MS Mus musculus
62 BTRC 8945
Affinity Capture-MS Homo sapiens
63 MYCN  
Affinity Capture-MS Homo sapiens
64 UBAP2L 9898
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
65 SOX5 6660
Affinity Capture-MS Homo sapiens
66 GNB2L1 10399
Affinity Capture-MS Homo sapiens
67 RPL19 6143
Affinity Capture-MS Homo sapiens
68 RBM8A 9939
Affinity Capture-MS Homo sapiens
69 KIF14 9928
Affinity Capture-MS Homo sapiens
70 HSPA8 3312
Affinity Capture-MS Homo sapiens
71 TPT1 7178
Affinity Capture-MS Homo sapiens
72 CPEB1  
Proximity Label-MS Homo sapiens
73 KLF16  
Affinity Capture-MS Homo sapiens
74 CLOCK  
Affinity Capture-MS Homo sapiens
75 SRP9 6726
Affinity Capture-MS Homo sapiens
76 TMEM14B  
Affinity Capture-MS Homo sapiens
77 COASY 80347
Cross-Linking-MS (XL-MS) Homo sapiens
78 PSENEN  
Affinity Capture-MS Homo sapiens
79 CTDP1 9150
Affinity Capture-MS Homo sapiens
80 RBFOX2 23543
Affinity Capture-MS Homo sapiens
81 FGA 2243
Two-hybrid Homo sapiens
82 DRG1 4733
Affinity Capture-MS Homo sapiens
83 MAPRE1 22919
Proximity Label-MS Homo sapiens
84 GAGE2E 26749
Affinity Capture-MS Homo sapiens
85 IFI27L1  
Affinity Capture-MS Homo sapiens
86 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
87 RPL5 6125
Affinity Capture-MS Homo sapiens
88 DDX20 11218
Two-hybrid Homo sapiens
89 YWHAE 7531
Affinity Capture-MS Homo sapiens
90 C16orf58 64755
Affinity Capture-MS Homo sapiens
91 RAN 5901
Cross-Linking-MS (XL-MS) Homo sapiens
92 NTRK1 4914
Affinity Capture-MS Homo sapiens
93 GORASP2 26003
Two-hybrid Homo sapiens
94 PNMA2  
Affinity Capture-MS Homo sapiens
95 PRMT2  
Two-hybrid Homo sapiens
96 DDX54 79039
Affinity Capture-MS Homo sapiens
97 Arhgap18  
Affinity Capture-MS Mus musculus
98 GANAB 23193
Two-hybrid Homo sapiens
99 HECTD1 25831
Affinity Capture-MS Homo sapiens
100 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
101 RPS16 6217
Affinity Capture-MS Homo sapiens
102 CCR10  
Two-hybrid Homo sapiens
103 DUSP23 54935
Affinity Capture-MS Homo sapiens
104 CEBPA  
Protein-peptide Homo sapiens
105 CYLD  
Affinity Capture-MS Homo sapiens
106 SDHAP2  
Affinity Capture-MS Homo sapiens
107 NEIL3  
Protein-RNA Homo sapiens
108 HMGB2 3148
Affinity Capture-MS Homo sapiens
109 C1orf189  
Affinity Capture-MS Homo sapiens
110 ATXN1 6310
Two-hybrid Homo sapiens
111 TPX2  
Affinity Capture-MS Homo sapiens
112 EIF3G 8666
Affinity Capture-MS Homo sapiens
113 SFPQ 6421
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 PSMA3 5684
Two-hybrid Homo sapiens
115 CPSF1 29894
Two-hybrid Homo sapiens
116 ERLEC1 27248
Affinity Capture-MS Homo sapiens
117 RERE 473
Two-hybrid Homo sapiens
118 TCEAL7  
Affinity Capture-MS Homo sapiens
119 SOX6  
Affinity Capture-MS Homo sapiens
120 RC3H2  
Affinity Capture-MS Homo sapiens
121 SIRT7  
Affinity Capture-MS Homo sapiens
122 MEX3A  
Affinity Capture-RNA Homo sapiens
123 USP36  
Affinity Capture-MS Homo sapiens
124 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 RPS8 6202
Affinity Capture-MS Homo sapiens
126 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
127 BEX1  
Affinity Capture-MS Homo sapiens
128 RBFOX1 54715
Two-hybrid Homo sapiens
129 HNRNPA1 3178
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
130 TDRD3  
Affinity Capture-MS Homo sapiens
131 MYC  
Affinity Capture-MS Homo sapiens
132 JUN 3725
Reconstituted Complex Homo sapiens
133 MAPRE3  
Proximity Label-MS Homo sapiens
134 CHCHD2  
Affinity Capture-MS Homo sapiens
135 RBM42  
Affinity Capture-MS Homo sapiens
136 PSPC1 55269
Affinity Capture-MS Homo sapiens
137 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
138 HIST1H2BA 255626
Cross-Linking-MS (XL-MS) Homo sapiens
139 POMZP3  
Affinity Capture-MS Homo sapiens
140 RPA4  
Proximity Label-MS Homo sapiens
141 Abr 109934
Affinity Capture-MS Mus musculus
142 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
143 DPM2 8818
Affinity Capture-MS Homo sapiens
144 RPS11 6205
Affinity Capture-MS Homo sapiens
145 BMI1  
Affinity Capture-MS Homo sapiens
146 TMSB4Y  
Affinity Capture-MS Homo sapiens
147 CYCS 54205
Affinity Capture-MS Homo sapiens
148 HUWE1 10075
Affinity Capture-MS Homo sapiens
149 SUMO1 7341
Affinity Capture-MS Homo sapiens
150 IMMT 10989
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
151 MAPKAPK2 9261
Affinity Capture-MS Homo sapiens
152 EIF3F 8665
Affinity Capture-MS Homo sapiens
153 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
154 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 GRB2 2885
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
156 WDR77 79084
Affinity Capture-MS Homo sapiens
157 FBXL6  
Affinity Capture-MS Homo sapiens
158 TP53 7157
Affinity Capture-MS Homo sapiens
159 WWOX 51741
Affinity Capture-MS Homo sapiens
160 ATXN1L  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
161 HOXB6 3216
Affinity Capture-MS Homo sapiens
162 SAA1 6288
Affinity Capture-MS Homo sapiens
163 RPA1 6117
Affinity Capture-MS Homo sapiens
164 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
165 HNRNPM 4670
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
166 SHFM1 7979
Affinity Capture-MS Homo sapiens
167 CAPN13  
Affinity Capture-MS Homo sapiens
168 SRP72 6731
Affinity Capture-MS Homo sapiens
169 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
170 G3BP2 9908
Affinity Capture-MS Homo sapiens
171 EZH1  
Affinity Capture-MS Homo sapiens
172 SSR3 6747
Two-hybrid Homo sapiens
173 STOML2 30968
Cross-Linking-MS (XL-MS) Homo sapiens
174 NCK2 8440
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 ESR1  
Affinity Capture-MS Homo sapiens
176 KLF5  
Affinity Capture-MS Homo sapiens
177 C20orf197  
Affinity Capture-MS Homo sapiens
178 WWP2 11060
Affinity Capture-MS Homo sapiens
179 SPCS1 28972
Affinity Capture-MS Homo sapiens
180 CIT 11113
Affinity Capture-MS Homo sapiens
181 GAGE5  
Affinity Capture-MS Homo sapiens
182 GRSF1 2926
Co-fractionation Homo sapiens
183 C1QBP 708
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
184 SERBP1 26135
Proximity Label-MS Homo sapiens
185 EHHADH 1962
Affinity Capture-MS Homo sapiens
186 CUL7 9820
Affinity Capture-MS Homo sapiens
187 B3GNT2 10678
Affinity Capture-MS Homo sapiens
188 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
189 RC3H1 149041
Affinity Capture-MS Homo sapiens
190 SSRP1 6749
Affinity Capture-MS Homo sapiens
191 PTCH1  
Affinity Capture-MS Homo sapiens
192 PRMT1 3276
Affinity Capture-MS Homo sapiens
193 LUC7L 55692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
194 UQCR11  
Affinity Capture-MS Homo sapiens
195 TRPC4AP  
Affinity Capture-MS Homo sapiens
196 EIF5 1983
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRRC2A is involved
No pathways found





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