Gene description for WWOX
Gene name WW domain containing oxidoreductase
Gene symbol WWOX
Other names/aliases D16S432E
EIEE28
FOR
FRA16D
HHCMA56
PRO0128
SCAR12
SDR41C1
WOX1
Species Homo sapiens
 Database cross references - WWOX
ExoCarta ExoCarta_51741
Vesiclepedia VP_51741
Entrez Gene 51741
HGNC 12799
MIM 605131
UniProt Q9NZC7  
 WWOX identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for WWOX
Molecular Function
    coenzyme binding GO:0050662 TAS
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 TAS
    enzyme binding GO:0019899 IPI
    protein dimerization activity GO:0046983 TAS
    RNA polymerase II transcription coactivator activity GO:0001105 ISS
    cofactor binding GO:0048037 TAS
Biological Process
    extrinsic apoptotic signaling pathway GO:0097191 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IDA
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 ISS
    skeletal system morphogenesis GO:0048705 ISS
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IEA
    intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 IEA
    steroid metabolic process GO:0008202 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    Wnt signaling pathway GO:0016055 IEA
    osteoblast differentiation GO:0001649 IEA
    oxidation-reduction process GO:0055114 TAS
    negative regulation of Wnt signaling pathway GO:0030178 IDA
Subcellular Localization
    RNA polymerase II transcription factor complex GO:0090575 ISS
    microvillus GO:0005902 IDA
    cytoplasm GO:0005737 TAS
    plasma membrane GO:0005886 IDA
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 ISS
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified WWOX in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for WWOX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TP53 7157
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which WWOX is involved
PathwayEvidenceSource
Nuclear signaling by ERBB4 TAS Reactome





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