ExoCarta: Gene summary

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Gene description for WWOX
Gene name	WW domain containing oxidoreductase
Gene symbol	WWOX
Other names/aliases	D16S432E EIEE28 FOR FRA16D HHCMA56 PRO0128 SCAR12 SDR41C1 WOX1
Species	Homo sapiens
Database cross references - WWOX
ExoCarta	ExoCarta_51741
Vesiclepedia	VP_51741
Entrez Gene	51741
HGNC	12799
MIM	605131
UniProt	Q9NZC7
WWOX identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells	35333565
Retinal pigment epithelial cells	35333565

Gene ontology annotations for WWOX

Molecular Function
	transcription coactivator activity	GO:0003713	ISS
	protein binding	GO:0005515	IPI
	oxidoreductase activity	GO:0016491	NAS
	enzyme binding	GO:0019899	IPI
	identical protein binding	GO:0042802	IPI
Biological Process
	osteoblast differentiation	GO:0001649	IEA
	Wnt signaling pathway	GO:0016055	IEA
	negative regulation of Wnt signaling pathway	GO:0030178	IDA
	positive regulation of transcription by RNA polymerase II	GO:0045944	ISS
	skeletal system morphogenesis	GO:0048705	ISS
	cellular response to transforming growth factor beta stimulus	GO:0071560	IDA
	intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	IEA
	extrinsic apoptotic signaling pathway	GO:0097191	IEA
	positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	ISS
	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001241	IEA
Subcellular Localization
	nucleus	GO:0005634	IDA
	cytoplasm	GO:0005737	IDA
	mitochondrion	GO:0005739	ISS
	lysosome	GO:0005764	IEA
	Golgi apparatus	GO:0005794	IDA
	cytosol	GO:0005829	IDA
	cytosol	GO:0005829	TAS
	plasma membrane	GO:0005886	IDA
	microvillus	GO:0005902	IDA
	RNA polymerase II transcription regulator complex	GO:0090575	ISS

Experiment description of studies that identified WWOX in sEVs

Experiment ID

834

MISEV standards
✔ EM	Biophysical techniques
✔ LAMP2\|CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

835

MISEV standards
✔ EM	Biophysical techniques
✔ CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Protein-protein interactions for WWOX

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

EIF3A

8661

Affinity Capture-MS

Homo sapiens

WDR91

29062

Affinity Capture-MS

Homo sapiens

GJD3

Proximity Label-MS

Homo sapiens

DGCR14

Affinity Capture-MS

Homo sapiens

ATG9A

79065

Proximity Label-MS

Homo sapiens

FKBP15

23307

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

DDX17

10521

Affinity Capture-MS

Homo sapiens

SMARCE1

6605

Affinity Capture-MS

Homo sapiens

KRT4

3851

Affinity Capture-MS

Homo sapiens

CSNK2A1

1457

Affinity Capture-MS

Homo sapiens

SCAF4

57466

Affinity Capture-MS

Homo sapiens

FBRS

64319

Affinity Capture-MS

Homo sapiens

ATN1

Affinity Capture-MS

Homo sapiens

GNE

10020

Two-hybrid

Homo sapiens

PSMB8

5696

Two-hybrid

Homo sapiens

AMOTL1

154810

Affinity Capture-MS

Homo sapiens

LONP2

83752

Affinity Capture-MS

Homo sapiens

IGF2BP3

10643

Affinity Capture-MS

Homo sapiens

C11orf87

Two-hybrid

Homo sapiens

USP6NL

9712

Affinity Capture-MS

Homo sapiens

MPP5

64398

Affinity Capture-MS

Homo sapiens

APBB2

Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens

USP39

10713

Affinity Capture-MS

Homo sapiens

PLAC8

Two-hybrid

Homo sapiens

AMOT

154796

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

CPSF7

79869

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

DCTPP1

79077

Affinity Capture-MS

Homo sapiens

MARCH5

Proximity Label-MS

Homo sapiens

OTUD7B

56957

Affinity Capture-MS

Homo sapiens

SNRPD3

6634

Affinity Capture-MS

Homo sapiens

SLC25A46

91137

Proximity Label-MS

Homo sapiens

POLR2C

5432

Affinity Capture-MS

Homo sapiens

ZNF598

90850

Affinity Capture-MS

Homo sapiens

WBP2

23558

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

RBMX

27316

Affinity Capture-MS

Homo sapiens

FARSA

2193

Affinity Capture-MS

Homo sapiens

NEDD9

4739

Two-hybrid

Homo sapiens

HN1L

90861

Affinity Capture-MS

Homo sapiens

TSGA10IP

Two-hybrid

Homo sapiens

CAPZA1

829

Affinity Capture-MS

Homo sapiens

WBP1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CSTF2

1478

Affinity Capture-MS

Homo sapiens

SRSF3

6428

Affinity Capture-MS

Homo sapiens

DAZAP2

Two-hybrid

Homo sapiens

PABPC1

26986

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

CDH1

999

Proximity Label-MS

Homo sapiens

ALDH3A1

218

Affinity Capture-MS

Homo sapiens

OGT

8473

Affinity Capture-MS

Homo sapiens

SLC15A2

6565

Two-hybrid

Homo sapiens

TCHP

Two-hybrid

Homo sapiens

C10orf55

Two-hybrid

Homo sapiens

MYH16

Affinity Capture-MS

Homo sapiens

ENO1

2023

Affinity Capture-MS

Homo sapiens

MED25

Two-hybrid

Homo sapiens

ZNF581

Two-hybrid

Homo sapiens

VENTX

Two-hybrid

Homo sapiens

DDX39B

7919

Affinity Capture-MS

Homo sapiens

CSTF3

1479

Affinity Capture-MS

Homo sapiens

TMEM171

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

MPDZ

Affinity Capture-MS

Homo sapiens

PDCD7

Affinity Capture-MS

Homo sapiens

SRPK1

6732

Affinity Capture-MS

Homo sapiens

U2SURP

23350

Affinity Capture-MS

Homo sapiens

FAM189B

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PKLR

5313

Affinity Capture-MS

Homo sapiens

RBM39

9584

Affinity Capture-MS

Homo sapiens

HADHA

3030

Affinity Capture-MS

Homo sapiens

ANXA1

301

Affinity Capture-MS

Homo sapiens

BCAP31

10134

Proximity Label-MS

Homo sapiens

YWHAZ

7534

Affinity Capture-MS

Homo sapiens

ERBB4

2066

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

PRMT5

10419

Affinity Capture-MS

Homo sapiens

SF3B6

51639

Affinity Capture-MS

Homo sapiens

HSPA1A

3303

Affinity Capture-MS

Homo sapiens

HSPA4

3308

Affinity Capture-MS

Homo sapiens

PRPF40A

55660

Affinity Capture-MS

Homo sapiens

ACY1

Two-hybrid

Homo sapiens

CYP2C9

Proximity Label-MS

Homo sapiens

CSDE1

7812

Affinity Capture-MS

Homo sapiens

PABPC3

5042

Affinity Capture-MS

Homo sapiens

CXorf57

Affinity Capture-MS

Homo sapiens

CRNN

49860

Affinity Capture-MS

Homo sapiens

NOSIP

51070

Affinity Capture-MS

Homo sapiens

NUDT21

11051

Reconstituted Complex

Homo sapiens

DVL1

1855

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

FASN

2194

Negative Genetic

Homo sapiens

WDR77

79084

Affinity Capture-MS

Homo sapiens

VOPP1

Affinity Capture-MS

Homo sapiens

WWOX

51741

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

TCERG1

10915

Reconstituted Complex

Homo sapiens

SCAF8

22828

Affinity Capture-MS

Homo sapiens

SMN2

6607

Affinity Capture-MS

Homo sapiens

MYH1

Affinity Capture-MS

Homo sapiens

CPSF2

53981

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

PRPF31

26121

Affinity Capture-MS

Homo sapiens

LATS1

Protein-peptide

Homo sapiens

GORASP1

64689

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ATAD3A

55210

Affinity Capture-MS

Homo sapiens

3550

Affinity Capture-MS

Homo sapiens

100

DDR1

780

Affinity Capture-MS

Homo sapiens

101

HSPB2-C11orf52

Two-hybrid

Homo sapiens

102

TRIM69

140691

Two-hybrid

Homo sapiens

103

EPHA2

1969

Proximity Label-MS

Homo sapiens

104

RAB5C

5878

Proximity Label-MS

Homo sapiens

105

ANXA2

302

Affinity Capture-MS

Homo sapiens

106

IFIT2

3433

Two-hybrid

Homo sapiens

107

LRP3

Affinity Capture-MS

Homo sapiens

108

HNRNPH1

3187

Affinity Capture-RNA

Homo sapiens

109

LYZ

4069

Affinity Capture-MS

Homo sapiens

110

METTL7A

25840

Proximity Label-MS

Homo sapiens

111

LAMP3

Proximity Label-MS

Homo sapiens

112

GJA1

2697

Proximity Label-MS

Homo sapiens

113

TARDBP

23435

Affinity Capture-MS

Homo sapiens

114

THRAP3

9967

Affinity Capture-MS

Homo sapiens

115

SF3B1

23451

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

116

NOP56

10528

Affinity Capture-MS

Homo sapiens

117

ATM

472

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

118

LZTS3

Affinity Capture-MS

Homo sapiens

119

PBX4

Two-hybrid

Homo sapiens

120

SMR3A

Two-hybrid

Homo sapiens

121

DIAPH1

1729

Affinity Capture-MS

Homo sapiens

122

KRT3

3850

Two-hybrid

Homo sapiens

123

NOLC1

9221

Affinity Capture-MS

Homo sapiens

124

CPSF1

29894

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

125

SEC24C

9632

Affinity Capture-MS

Homo sapiens

126

ANAPC11

Two-hybrid

Homo sapiens

127

RPN2

6185

Proximity Label-MS

Homo sapiens

128

PTPN14

5784

Affinity Capture-MS

Homo sapiens

129

DDX6

1656

Affinity Capture-MS

Homo sapiens

130

LDLRAD4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

131

CREB5

9586

Two-hybrid

Homo sapiens

132

FAM154A

Two-hybrid

Homo sapiens

133

LMAN1

3998

Proximity Label-MS

Homo sapiens

134

CCT2

10576

Affinity Capture-MS

Homo sapiens

135

SYMPK

8189

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

136

PRPF8

10594

Affinity Capture-MS

Homo sapiens

137

DDX21

9188

Affinity Capture-MS

Homo sapiens

138

DRG1

4733

Affinity Capture-MS

Homo sapiens

139

ACIN1

22985

Affinity Capture-MS

Homo sapiens

140

SNRNP200

23020

Affinity Capture-MS

Homo sapiens

141

SNRPD1

6632

Affinity Capture-MS

Homo sapiens

142

ABHD11

83451

Two-hybrid

Homo sapiens

143

DCAF7

10238

Affinity Capture-MS

Homo sapiens

144

ACAT2

Two-hybrid

Homo sapiens

145

PATL1

219988

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

146

PREB

10113

Affinity Capture-MS

Homo sapiens

147

AGPS

8540

Proximity Label-MS

Homo sapiens

148

BDH2

56898

Affinity Capture-MS

Homo sapiens

149

IQSEC1

9922

Affinity Capture-MS

Homo sapiens

150

KHSRP

8570

Affinity Capture-MS

Homo sapiens

151

ACLY

Affinity Capture-MS

Homo sapiens

152

CANX

821

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

153

DHX36

170506

Affinity Capture-MS

Homo sapiens

154

UBAP2

55833

Affinity Capture-MS

Homo sapiens

155

POLR2E

5434

Affinity Capture-MS

Homo sapiens

156

WDR33

55339

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

157

ATP5F1

515

Affinity Capture-MS

Homo sapiens

158

YLPM1

56252

Affinity Capture-MS

Homo sapiens

159

HSD17B10

3028

Affinity Capture-MS

Homo sapiens

160

FUS

2521

Affinity Capture-MS

Homo sapiens

161

HOXA1

3198

Two-hybrid

Homo sapiens

162

KLHDC7B

Two-hybrid

Homo sapiens

163

TFG

10342

Two-hybrid

Homo sapiens

164

KDM3B

Affinity Capture-MS

Homo sapiens

165

RAPGEF2

9693

Affinity Capture-MS

Homo sapiens

166

ATP2A1

487

Affinity Capture-MS

Homo sapiens

167

CSNK2A2

1459

Affinity Capture-MS

Homo sapiens

168

SHC3

Two-hybrid

Homo sapiens

169

SH2D4A

63898

Two-hybrid

Homo sapiens

170

HUWE1

10075

Affinity Capture-MS

Homo sapiens

171

DSP

1832

Affinity Capture-MS

Homo sapiens

172

C17orf80

55028

Proximity Label-MS

Homo sapiens

173

PRRC2A

7916

Affinity Capture-MS

Homo sapiens

174

TOE1

114034

Affinity Capture-MS

Homo sapiens

175

DIDO1

Affinity Capture-MS

Homo sapiens

176

TP53

7157

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens

177

CTAG1B

Two-hybrid

Homo sapiens

178

SPG20

23111

Affinity Capture-MS

Homo sapiens

179

HNRNPK

3190

Reconstituted Complex

Homo sapiens

180

DCD

117159

Affinity Capture-MS

Homo sapiens

181

ERGIC2

51290

Proximity Label-MS

Homo sapiens

182

ABI2

10152

Two-hybrid

Homo sapiens

183

IGF2BP2

10644

Affinity Capture-MS

Homo sapiens

184

KRT34

Two-hybrid

Homo sapiens

185

CPSF3

51692

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

186

PITX2

Two-hybrid

Homo sapiens

187

WIPF2

147179

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

188

FRS3

10817

Two-hybrid

Homo sapiens

189

C19orf54

Two-hybrid

Homo sapiens

190

RARRES3

Affinity Capture-MS

Homo sapiens

191

HSD17B11

51170

Proximity Label-MS

Homo sapiens

192

XRN2

22803

Affinity Capture-MS

Homo sapiens

193

HNRNPCL1

343069

Affinity Capture-MS

Homo sapiens

194

HNRNPR

10236

Affinity Capture-MS

Homo sapiens

195

ZNF414

Two-hybrid

Homo sapiens

196

HIST2H2AA3

8337

Affinity Capture-MS

Homo sapiens

197

DROSHA

Affinity Capture-MS

Homo sapiens

198

ZBTB33

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

199

TRIM28

10155

Affinity Capture-Western

Homo sapiens

200

DAZAP1

26528

Affinity Capture-MS

Homo sapiens

201

SSR1

6745

Proximity Label-MS

Homo sapiens

202

SF3A2

8175

Affinity Capture-MS

Homo sapiens

203

PGD

5226

Affinity Capture-MS

Homo sapiens

204

DSG3

1830

Affinity Capture-MS

Homo sapiens

205

ATRX

546

Co-localization

Homo sapiens

206

CSNK2B

1460

Two-hybrid

Homo sapiens

207

TEX37

Two-hybrid

Homo sapiens

208

PABPC4

8761

Affinity Capture-MS

Homo sapiens

209

CYYR1

Affinity Capture-MS

Homo sapiens

210

HSPA8

3312

Affinity Capture-MS

Homo sapiens

211

NUP155

9631

Proximity Label-MS

Homo sapiens

212

PXMP2

Proximity Label-MS

Homo sapiens

213

FAM222B

Two-hybrid

Homo sapiens

214

VEZF1

Two-hybrid

Homo sapiens

215

P4HA1

5033

Affinity Capture-MS

Homo sapiens

216

FOXD4L1

Two-hybrid

Homo sapiens

217

ZMAT5

Affinity Capture-MS

Homo sapiens

218

LRRC10

Affinity Capture-MS

Homo sapiens

219

GLIS2

Two-hybrid

Homo sapiens

220

GOLGA2

2801

Proximity Label-MS

Homo sapiens

221

FAM103A1

Two-hybrid

Homo sapiens

222

DHFRL1

Proximity Label-MS

Homo sapiens

223

DHX9

1660

Affinity Capture-MS

Homo sapiens

224

HNRNPA3

220988

Affinity Capture-MS

Homo sapiens

225

SF3A3

10946

Affinity Capture-MS

Homo sapiens

226

POLR2B

5431

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

227

SF3B2

10992

Affinity Capture-MS

Homo sapiens

228

TTYH1

Affinity Capture-MS

Homo sapiens

229

DDX3Y

8653

Affinity Capture-MS

Homo sapiens

230

KLHL38

Two-hybrid

Homo sapiens

231

FOXI1

Two-hybrid

Homo sapiens

232

RPRD2

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

233

HSD3B7

80270

Proximity Label-MS

Homo sapiens

234

TNK2

10188

Affinity Capture-MS		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

235

DHX30

22907

Affinity Capture-MS

Homo sapiens

236

HNRNPUL1

11100

Affinity Capture-MS

Homo sapiens

237

CYFIP2

26999

Affinity Capture-MS

Homo sapiens

238

TP73

Affinity Capture-MS

Homo sapiens

239

SERPINB5

5268

Affinity Capture-MS

Homo sapiens

240

OTX1

Two-hybrid

Homo sapiens

241

OCIAD1

54940

Proximity Label-MS

Homo sapiens

242

A2ML1

144568

Affinity Capture-MS

Homo sapiens

243

LACRT

90070

Affinity Capture-MS

Homo sapiens

244

MTOR

2475

Affinity Capture-Western

Homo sapiens

245

TP63

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

246

MATR3

9782

Affinity Capture-MS

Homo sapiens

247

HDLBP

3069

Affinity Capture-MS

Homo sapiens

248

MYH7

4625

Affinity Capture-MS

Homo sapiens

249

GCM2

Two-hybrid

Homo sapiens

250

IGLC1

3537

Affinity Capture-MS

Homo sapiens

251

TMEM92

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

252

ACBD5

91452

Proximity Label-MS

Homo sapiens

253

HIF1A

3091

Affinity Capture-Western

Homo sapiens

254

KIF2A

3796

Affinity Capture-MS

Homo sapiens

255

RARA

5914

Affinity Capture-MS

Homo sapiens

256

SCGB2A1

4246

Affinity Capture-MS

Homo sapiens

257

CTDSP1

58190

Two-hybrid

Homo sapiens

258

JUP

3728

Affinity Capture-MS

Homo sapiens

259

SEC23IP

11196

Affinity Capture-MS

Homo sapiens

260

RPL6

6128

Affinity Capture-MS

Homo sapiens

261

OLIG3

Two-hybrid

Homo sapiens

262

LDLRAD1

Affinity Capture-MS

Homo sapiens

263

INCA1

Two-hybrid

Homo sapiens

264

GABARAPL2

11345

Affinity Capture-MS

Homo sapiens

265

LITAF

9516

Two-hybrid

Homo sapiens

266

MKRN3

Two-hybrid

Homo sapiens

267

HSPB1

3315

Affinity Capture-MS

Homo sapiens

268

THOC6

79228

Affinity Capture-MS

Homo sapiens

269

ERGIC1

57222

Proximity Label-MS

Homo sapiens

270

CCT7

10574

Affinity Capture-MS

Homo sapiens

271

BABAM1

29086

Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens

272

HNRNPH3

3189

Affinity Capture-MS

Homo sapiens

273

RAB7A

7879

Proximity Label-MS

Homo sapiens

274

ZG16B

124220

Affinity Capture-MS

Homo sapiens

275

HNRNPF

3185

Affinity Capture-MS

Homo sapiens

276

RPRD1B

58490

Affinity Capture-MS

Homo sapiens

277

CYFIP1

23191

Affinity Capture-MS

Homo sapiens

278

RC3H1

149041

Affinity Capture-MS

Homo sapiens

279

CAV1

857

Proximity Label-MS

Homo sapiens

280

LUC7L3

51747

Affinity Capture-MS

Homo sapiens

281

PLEKHN1

Two-hybrid

Homo sapiens

282

POLR2G

5436

Affinity Capture-MS

Homo sapiens

283

ENKD1

Two-hybrid

Homo sapiens

284

BCL9

Affinity Capture-MS

Homo sapiens

285

KRTAP11-1

Two-hybrid

Homo sapiens

286

CCDC24

Two-hybrid

Homo sapiens

287

COIL

Affinity Capture-MS

Homo sapiens

288

RPS15AP21

Affinity Capture-MS

Homo sapiens

289

RPL30

6156

Affinity Capture-MS

Homo sapiens

290

UFSP1

Two-hybrid

Homo sapiens

291

PAICS

10606

Affinity Capture-MS

Homo sapiens

292

TDRD3

Affinity Capture-MS

Homo sapiens

293

LSM4

25804

Affinity Capture-MS

Homo sapiens

294

SMYD5

10322

Affinity Capture-MS

Homo sapiens

295

LAMP2

3920

Proximity Label-MS

Homo sapiens

296

PRPF3

Affinity Capture-MS

Homo sapiens

297

ZIC1

Two-hybrid

Homo sapiens

298

DVL3

1857

Affinity Capture-MS

Homo sapiens

299

SNRPD2

6633

Affinity Capture-MS

Homo sapiens

300

TEKT3

64518

Two-hybrid

Homo sapiens

301

B3GAT1

Proximity Label-MS

Homo sapiens

302

TFAP2C

7022

Reconstituted Complex

Homo sapiens

303

DIAPH3

81624

Affinity Capture-MS

Homo sapiens

304

SNRPC

6631

Two-hybrid

Homo sapiens

305

SERPINA5

5104

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

306

DGCR2

9993

Affinity Capture-MS

Homo sapiens

307

WASL

8976

Affinity Capture-MS

Homo sapiens

308

P3H1

64175

Affinity Capture-MS

Homo sapiens

309

PLSCR3

57048

Two-hybrid

Homo sapiens

310

NME2

4831

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

311

SEC23A

10484

Affinity Capture-MS

Homo sapiens

312

SLC4A1AP

Affinity Capture-MS

Homo sapiens

313

FEM1A

Two-hybrid

Homo sapiens

314

DVL2

1856

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

315

LAMTOR1

55004

Proximity Label-MS

Homo sapiens

316

EDC4

23644

Affinity Capture-MS

Homo sapiens

317

H2AFZ

3015

Affinity Capture-MS

Homo sapiens

318

GEMIN5

25929

Affinity Capture-MS

Homo sapiens

319

PPP1CA

5499

Affinity Capture-MS

Homo sapiens

320

PPIB

5479

Affinity Capture-MS

Homo sapiens

321

PRDX5

25824

Affinity Capture-MS

Homo sapiens

322

NONO

4841

Affinity Capture-MS

Homo sapiens

323

CNNM3

26505

Two-hybrid

Homo sapiens

324

SMARCA4

6597

Affinity Capture-MS

Homo sapiens

325

GEM

Two-hybrid

Homo sapiens

326

KRT75

9119

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

327

MIA3

375056

Affinity Capture-MS

Homo sapiens

328

ARRDC3

57561

Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

329

C12orf10

60314

Two-hybrid

Homo sapiens

330

LCN1

3933

Affinity Capture-MS

Homo sapiens

331

DDX1

1653

Affinity Capture-MS

Homo sapiens

332

ITCH

83737

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

333

ELOVL5

60481

Proximity Label-MS

Homo sapiens

334

ENAH

55740

Affinity Capture-MS

Homo sapiens

335

MYH4

Affinity Capture-MS

Homo sapiens

336

CTAG1A

Two-hybrid

Homo sapiens

337

SFPQ

6421

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

338

SERPINB3

6317

Affinity Capture-MS

Homo sapiens

339

IVL

3713

Affinity Capture-MS

Homo sapiens

340

DOCK7

85440

Affinity Capture-MS

Homo sapiens

341

RPN1

6184

Proximity Label-MS

Homo sapiens

342

CCT6A

908

Affinity Capture-MS

Homo sapiens

343

LAMP1

3916

Proximity Label-MS

Homo sapiens

344

MYOZ1

Two-hybrid

Homo sapiens

345

XAB2

56949

Affinity Capture-MS

Homo sapiens

346

RPRD1A

Affinity Capture-MS

Homo sapiens

347

SF3A1

10291

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

348

LZTS2

84445

Affinity Capture-MS

Homo sapiens

349

DKC1

1736

Affinity Capture-MS

Homo sapiens

350

RPAP3

79657

Affinity Capture-MS

Homo sapiens

351

FIP1L1

81608

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

352

SRSF10

10772

Affinity Capture-MS

Homo sapiens

353

PPP1R32

Two-hybrid

Homo sapiens

354

SF3B3

23450

Reconstituted Complex

Homo sapiens

355

POLR2A

5430

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

356

BAIAP2

10458

Affinity Capture-MS

Homo sapiens

357

MDM2

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

358

KIAA1522

57648

Affinity Capture-MS

Homo sapiens

359

DHX15

1665

Affinity Capture-MS

Homo sapiens

360

PEF1

553115

Two-hybrid

Homo sapiens

361

HSPB2

Two-hybrid

Homo sapiens

362

CPSF6

11052

Two-hybrid		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

363

VPS37C

55048

Two-hybrid

Homo sapiens

364

INPPL1

3636

Affinity Capture-MS

Homo sapiens

365

ADRA2C

Two-hybrid

Homo sapiens

366

SMARCC1

6599

Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

367

ATXN2

6311

Affinity Capture-MS

Homo sapiens

368

MYOZ2

51778

Two-hybrid

Homo sapiens

369

ELAVL1

1994

Affinity Capture-MS

Homo sapiens

370

EIF4A3

9775

Affinity Capture-MS

Homo sapiens

371

PAX9

Two-hybrid

Homo sapiens

372

ANXA11

311

Two-hybrid

Homo sapiens

373

TGM3

7053

Affinity Capture-MS

Homo sapiens

374

SEC62

7095

Proximity Label-MS

Homo sapiens

375

CAD

790

Affinity Capture-MS

Homo sapiens

376

RUSC1

Two-hybrid

Homo sapiens

377

FAM189A2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

378

IGF2BP1

10642

Affinity Capture-MS

Homo sapiens

379

HNRNPU

3192

Affinity Capture-MS

Homo sapiens

380

CDC5L

988

Affinity Capture-MS

Homo sapiens

381

ZNF135

Two-hybrid

Homo sapiens

View the network

Pathways in which WWOX is involved

Pathway	Evidence	Source
Activation of the TFAP2 (AP-2) family of transcription factors	TAS	Reactome
Gene expression (Transcription)	TAS	Reactome
Generic Transcription Pathway	TAS	Reactome
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	TAS	Reactome
Nuclear signaling by ERBB4	TAS	Reactome
RNA Polymerase II Transcription	TAS	Reactome
Signal Transduction	TAS	Reactome
Signaling by ERBB4	TAS	Reactome
Signaling by Receptor Tyrosine Kinases	TAS	Reactome
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here