Gene description for SSR1
Gene name signal sequence receptor, alpha
Gene symbol SSR1
Other names/aliases TRAPA
Species Homo sapiens
 Database cross references - SSR1
ExoCarta ExoCarta_6745
Entrez Gene 6745
HGNC 11323
MIM 600868
UniProt P43307  
 SSR1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for SSR1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    gene expression GO:0010467 TAS
    SRP-dependent cotranslational protein targeting to membrane GO:0006614 TAS
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    translation GO:0006412 TAS
    cellular protein metabolic process GO:0044267 TAS
    IRE1-mediated unfolded protein response GO:0036498 TAS
    positive regulation of cell proliferation GO:0008284 TAS
    cotranslational protein targeting to membrane GO:0006613 TAS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    endoplasmic reticulum GO:0005783 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified SSR1 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SSR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DKC1 1736
Two-hybrid Homo sapiens
2 UTP14A 10813
Two-hybrid Homo sapiens
3 PTN  
Two-hybrid Homo sapiens
4 EEF1A1 1915
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SSR1 is involved
PathwayEvidenceSource
SRP-dependent cotranslational protein targeting to membrane TAS Reactome
XBP1(S) activates chaperone genes TAS Reactome





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