Gene description for SMCR8
Gene name Smith-Magenis syndrome chromosome region, candidate 8
Gene symbol SMCR8
Other names/aliases -
Species Homo sapiens
 Database cross references - SMCR8
ExoCarta ExoCarta_140775
Entrez Gene 140775
HGNC 17921
UniProt Q8TEV9  
 SMCR8 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SMCR8
Subcellular Localization
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified SMCR8 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for SMCR8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SMCR8 is involved
No pathways found





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