Gene description for ATG13
Gene name autophagy related 13
Gene symbol ATG13
Other names/aliases KIAA0652
PARATARG8
Species Homo sapiens
 Database cross references - ATG13
ExoCarta ExoCarta_9776
Entrez Gene 9776
HGNC 29091
MIM 615088
UniProt O75143  
 ATG13 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
 Gene ontology annotations for ATG13
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
Biological Process
    positive regulation of protein targeting to mitochondrion GO:1903955 IMP
    autophagosome assembly GO:0000045 IMP
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
Subcellular Localization
    cytosol GO:0005829 IBA
    mitochondrion GO:0005739 IDA
    ATG1/UKL1 signaling complex GO:0034273 IBA
    ULK1-ATG13-FIP200 complex GO:0070969 IPI
    pre-autophagosomal structure GO:0000407 ISS
 Experiment description of studies that identified ATG13 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ATG13
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ATG13 is involved
No pathways found





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