Gene description for MAP1LC3B
Gene name microtubule-associated protein 1 light chain 3 beta
Gene symbol MAP1LC3B
Other names/aliases ATG8F
LC3B
MAP1A/1BLC3
MAP1LC3B-a
Species Homo sapiens
 Database cross references - MAP1LC3B
ExoCarta ExoCarta_81631
Entrez Gene 81631
HGNC 13352
MIM 609604
UniProt Q9GZQ8  
 MAP1LC3B identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for MAP1LC3B
Molecular Function
    microtubule binding GO:0008017 IBA
    protein binding GO:0005515 IPI
Biological Process
    cellular response to nitrogen starvation GO:0006995 IBA
    nucleophagy GO:0044804 IBA
    autophagosome assembly GO:0000045 IBA
    mitochondrion degradation GO:0000422 IBA
    membrane fusion GO:0061025 IBA
    regulation of mitochondrion degradation GO:1903146 IGI
Subcellular Localization
    endomembrane system GO:0012505 IEA
    extrinsic component of membrane GO:0019898 IBA
    organelle membrane GO:0031090 ISS
    mitochondrion GO:0005739 IDA
    autophagosome GO:0005776 ISS
    cytoplasmic vesicle GO:0031410 IEA
    microtubule GO:0005874 IEA
    cytosol GO:0005829 IBA
    pre-autophagosomal structure GO:0000407 IBA
    autophagosome membrane GO:0000421 IBA
    intracellular GO:0005622 IDA
    axoneme GO:0005930 ISS
 Experiment description of studies that identified MAP1LC3B in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for MAP1LC3B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SQSTM1 8878
Two-hybrid Homo sapiens
2 MGC2749  
Two-hybrid Homo sapiens
3 ATG4B 23192
Two-hybrid Homo sapiens
4 KBTBD7  
Two-hybrid Homo sapiens
5 LUC7L2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MAP1LC3B is involved
No pathways found





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