ExoCarta: Gene summary

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Gene description for KXD1
Gene name	KxDL motif containing 1
Gene symbol	KXD1
Other names/aliases	C19orf50 KXDL MST096 MSTP096
Species	Homo sapiens
Database cross references - KXD1
ExoCarta	ExoCarta_79036
Vesiclepedia	VP_79036
Entrez Gene	79036
HGNC	28420
MIM	615178
UniProt	Q9BQD3
KXD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Retinal pigment epithelial cells	35333565
Retinal pigment epithelial cells	35333565

Gene ontology annotations for KXD1

Molecular Function
	protein binding	GO:0005515	IPI
Biological Process
	vesicle-mediated transport	GO:0016192	ISS
	lysosome localization	GO:0032418	IBA
	lysosome localization	GO:0032418	IMP
	lysosome localization	GO:0032418	NAS
	regulation of endosome size	GO:0051036	NAS
	regulation of lysosome size	GO:0062196	NAS
	organelle transport along microtubule	GO:0072384	NAS
Subcellular Localization
	BLOC-1 complex	GO:0031083	ISS
	cytoplasmic side of lysosomal membrane	GO:0098574	NAS
	BORC complex	GO:0099078	IBA
	BORC complex	GO:0099078	IDA
	BORC complex	GO:0099078	IPI

Experiment description of studies that identified KXD1 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

834

MISEV standards
✔ EM	Biophysical techniques
✔ LAMP2\|CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

835

MISEV standards
✔ EM	Biophysical techniques
✔ CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Protein-protein interactions for KXD1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

GABARAPL1

23710

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

MCRS1

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

VPS35

55737

Affinity Capture-MS

Homo sapiens

KRT37

8688

Affinity Capture-MS

Homo sapiens

MPHOSPH9

Affinity Capture-MS

Homo sapiens

ATG5

9474

Affinity Capture-MS

Homo sapiens

TEX35

Affinity Capture-MS

Homo sapiens

BEGAIN

Affinity Capture-MS

Homo sapiens

GIT2

9815

Affinity Capture-MS

Homo sapiens

CCHCR1

Affinity Capture-MS

Homo sapiens

KIF20A

10112

Affinity Capture-MS

Homo sapiens

SRGAP2

23380

Affinity Capture-MS

Homo sapiens

CENPF

1063

Affinity Capture-MS

Homo sapiens

NAV2

Affinity Capture-MS

Homo sapiens

STX11

8676

Two-hybrid

Homo sapiens

TRIOBP

11078

Affinity Capture-MS

Homo sapiens

RNF40

9810

Affinity Capture-MS

Homo sapiens

RUFY1

80230

Affinity Capture-MS

Homo sapiens

MAP1LC3B

81631

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

VPS26A

9559

Affinity Capture-MS

Homo sapiens

WTAP

9589

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BLOC1S1

Affinity Capture-MS

Homo sapiens

NDE1

54820

Affinity Capture-MS

Homo sapiens

SNAPIN

23557

Affinity Capture-MS

Homo sapiens

IFT74

80173

Affinity Capture-MS

Homo sapiens

EXOC1

55763

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

HIP1

3092

Affinity Capture-MS

Homo sapiens

GOLGA3

2802

Affinity Capture-MS

Homo sapiens

AGGF1

Affinity Capture-MS

Homo sapiens

SH3BP1

23616

Affinity Capture-MS

Homo sapiens

CUX1

1523

Affinity Capture-MS

Homo sapiens

TNIK

23043

Affinity Capture-MS

Homo sapiens

TFIP11

Affinity Capture-MS

Homo sapiens

EWSR1

2130

Two-hybrid

Homo sapiens

CCDC33

80125

Two-hybrid

Homo sapiens

MID2

11043

Affinity Capture-MS

Homo sapiens

SLMO1

Affinity Capture-MS

Homo sapiens

TCEB3B

Two-hybrid

Homo sapiens

KIF2C

11004

Affinity Capture-MS

Homo sapiens

ATG16L1

55054

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

LAMTOR4

389541

Affinity Capture-MS

Homo sapiens

KIF15

56992

Affinity Capture-MS

Homo sapiens

KNSTRN

Affinity Capture-MS

Homo sapiens

EXOC7

23265

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

PRDM11

Affinity Capture-MS

Homo sapiens

NIF3L1

60491

Two-hybrid

Homo sapiens

EXOC5

10640

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

EXOC3

11336

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

IFT20

90410

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

CDC42BPG

55561

Affinity Capture-MS

Homo sapiens

C15orf59

Affinity Capture-MS

Homo sapiens

RABGEF1

27342

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens

SPAG5

10615

Affinity Capture-MS

Homo sapiens

S100A2

6273

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CENPH

Affinity Capture-MS

Homo sapiens

TRIML2

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

EML4

27436

Affinity Capture-MS

Homo sapiens

CEP55

55165

Affinity Capture-MS

Homo sapiens

RPL9

6133

Two-hybrid

Homo sapiens

KCTD10

83892

Affinity Capture-MS

Homo sapiens

LUZP1

7798

Affinity Capture-MS

Homo sapiens

SPDL1

Affinity Capture-MS

Homo sapiens

VPS51

738

Affinity Capture-MS

Homo sapiens

RAI14

26064

Affinity Capture-MS

Homo sapiens

NUDT18

Two-hybrid

Homo sapiens

RABEP1

9135

Affinity Capture-MS

Homo sapiens

TCEA2

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

NHS

4810

Affinity Capture-MS

Homo sapiens

EXOC4

60412

Affinity Capture-MS

Homo sapiens

TRIM24

Affinity Capture-MS

Homo sapiens

CEP19

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

ITSN2

50618

Two-hybrid

Homo sapiens

DTNBP1

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

GCC2

9648

Affinity Capture-MS

Homo sapiens

BLOC1S5

63915

Affinity Capture-MS

Homo sapiens

KIF5A

3798

Affinity Capture-MS

Homo sapiens

RAB11FIP4

Affinity Capture-MS

Homo sapiens

CDR2L

Affinity Capture-MS

Homo sapiens

CENPQ

Affinity Capture-MS

Homo sapiens

TACC1

6867

Affinity Capture-MS

Homo sapiens

EXOC6B

23233

Affinity Capture-MS

Homo sapiens

LAMTOR1

55004

Affinity Capture-MS

Homo sapiens

LRRC45

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

STX5

6811

Affinity Capture-MS

Homo sapiens

MEF2BNB

Affinity Capture-MS

Homo sapiens

ARHGDIG

Two-hybrid

Homo sapiens

EML1

2009

Affinity Capture-MS

Homo sapiens

TMF1

7110

Affinity Capture-MS

Homo sapiens

NUMA1

4926

Affinity Capture-MS

Homo sapiens

IFT57

55081

Affinity Capture-MS

Homo sapiens

MAB21L3

Two-hybrid

Homo sapiens

NEK9

91754

Affinity Capture-MS

Homo sapiens

WHAMMP3

Affinity Capture-MS

Homo sapiens

STXBP5

134957

Affinity Capture-MS

Homo sapiens

TSSC1

7260

Affinity Capture-MS

Homo sapiens

CEP63

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

CCDC185

Two-hybrid

Homo sapiens

TAX1BP1

8887

Affinity Capture-MS

Homo sapiens

TRAF7

Affinity Capture-MS

Homo sapiens

100

TRAF3IP1

26146

Affinity Capture-MS

Homo sapiens

101

ATG12

Affinity Capture-MS

Homo sapiens

102

ZC4H2

55906

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

103

TRAF6

7189

Affinity Capture-MS

Homo sapiens

104

RABGAP1

23637

Affinity Capture-MS

Homo sapiens

105

LAMTOR5

10542

Affinity Capture-MS

Homo sapiens

106

KRT27

342574

Affinity Capture-MS

Homo sapiens

107

KRT81

Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens

108

TPM1

7168

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

109

BICD2

23299

Affinity Capture-MS

Homo sapiens

110

FXR2

9513

Two-hybrid

Homo sapiens

111

ING5

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

112

RAB9A

9367

Proximity Label-MS

Homo sapiens

113

TRIM27

Affinity Capture-MS

Homo sapiens

114

ZBTB25

Two-hybrid

Homo sapiens

115

LOH12CR1

118426

Affinity Capture-MS

Homo sapiens

116

DYRK2

8445

Two-hybrid

Homo sapiens

117

MYH7

4625

Two-hybrid

Homo sapiens

118

SLMAP

7871

Affinity Capture-MS

Homo sapiens

119

ZNF417

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

120

TPM3

7170

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

121

TACC3

Affinity Capture-MS

Homo sapiens

122

PSMC3

5702

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

123

BLOC1S2

282991

Affinity Capture-MS

Homo sapiens

124

TACC2

10579

Affinity Capture-MS

Homo sapiens

125

SPICE1

Affinity Capture-MS

Homo sapiens

126

PSMC3IP

Affinity Capture-MS

Homo sapiens

127

TRAK2

66008

Affinity Capture-MS

Homo sapiens

128

USE1

55850

Affinity Capture-MS

Homo sapiens

129

APPL1

26060

Two-hybrid

Homo sapiens

130

CEP170P1

Two-hybrid

Homo sapiens

131

HAUS1

Two-hybrid

Homo sapiens

132

PTRF

284119

Affinity Capture-MS

Homo sapiens

133

RNF183

Two-hybrid

Homo sapiens

134

VPS52

6293

Affinity Capture-MS

Homo sapiens

135

C4orf46

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

136

BFSP1

Affinity Capture-MS

Homo sapiens

137

CLUAP1

23059

Affinity Capture-MS

Homo sapiens

138

PPP1R9B

84687

Affinity Capture-MS

Homo sapiens

139

FYCO1

79443

Affinity Capture-MS

Homo sapiens

140

RNF20

56254

Affinity Capture-MS

Homo sapiens

141

CEP250

11190

Affinity Capture-MS

Homo sapiens

142

TRIP11

9321

Affinity Capture-MS

Homo sapiens

143

IFT80

57560

Affinity Capture-MS

Homo sapiens

144

C10orf32

Affinity Capture-MS

Homo sapiens

145

UBB

7314

Affinity Capture-MS

Homo sapiens

146

MAP1LC3A

84557

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

147

LMO3

Two-hybrid

Homo sapiens

148

KRT38

8687

Affinity Capture-MS

Homo sapiens

149

VPS26B

112936

Affinity Capture-MS

Homo sapiens

150

HSF1

Affinity Capture-MS

Homo sapiens

151

RAB7A

7879

Proximity Label-MS

Homo sapiens

152

MYPOP

Affinity Capture-MS

Homo sapiens

153

RPRD1B

58490

Affinity Capture-MS

Homo sapiens

154

CDR2

Affinity Capture-MS

Homo sapiens

155

PEX5

5830

Affinity Capture-MS

Homo sapiens

156

CCDC136

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

157

TMCC2

Affinity Capture-MS

Homo sapiens

158

MOB1A

55233

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

159

UTP6

Two-hybrid

Homo sapiens

160

PSMC4

5704

Affinity Capture-MS

Homo sapiens

161

SNX29

Affinity Capture-MS

Homo sapiens

162

NEMF

9147

Affinity Capture-MS

Homo sapiens

163

IFT172

26160

Affinity Capture-MS

Homo sapiens

164

LNX1

Two-hybrid

Homo sapiens

165

NIN

51199

Affinity Capture-MS

Homo sapiens

166

C17orf59

54785

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

View the network

Pathways in which KXD1 is involved
No pathways found

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