Gene description for KRT37
Gene name keratin 37, type I
Gene symbol KRT37
Other names/aliases HA7
K37
KRTHA7
Species Homo sapiens
 Database cross references - KRT37
ExoCarta ExoCarta_8688
Vesiclepedia VP_8688
Entrez Gene 8688
HGNC 6455
MIM 604541
UniProt O76014  
 KRT37 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for KRT37
Molecular Function
    structural molecule activity GO:0005198 IEA
    protein binding GO:0005515 IPI
Biological Process
    epithelial cell differentiation GO:0030855 IBA
    intermediate filament organization GO:0045109 IBA
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IBA
    intermediate filament GO:0005882 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified KRT37 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for KRT37
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT76 51350
Two-hybrid Homo sapiens
2 KRT4 3851
Two-hybrid Homo sapiens
3 KRT6B 3854
Two-hybrid Homo sapiens
4 KRT1 3848
Two-hybrid Homo sapiens
5 AGXT  
Two-hybrid Homo sapiens
6 ATG5 9474
Affinity Capture-MS Homo sapiens
7 TRAF4 9618
Affinity Capture-MS Homo sapiens
8 SKI 6497
Affinity Capture-MS Homo sapiens
9 CCDC132 55610
Affinity Capture-MS Homo sapiens
10 APC  
Affinity Capture-MS Homo sapiens
11 EPS15 2060
Affinity Capture-MS Homo sapiens
12 TRIM33 51592
Affinity Capture-MS Homo sapiens
13 CALCOCO1 57658
Affinity Capture-MS Homo sapiens
14 BFSP2  
Two-hybrid Homo sapiens
15 RABGAP1L 9910
Affinity Capture-MS Homo sapiens
16 HAPLN2  
Two-hybrid Homo sapiens
17 CLCNKA  
Two-hybrid Homo sapiens
18 RUFY1 80230
Affinity Capture-MS Homo sapiens
19 COL8A1 1295
Two-hybrid Homo sapiens
20 HGS 9146
Two-hybrid Homo sapiens
21 ERC1 23085
Affinity Capture-MS Homo sapiens
22 OIP5  
Two-hybrid Homo sapiens
23 VTI1B 10490
Affinity Capture-MS Homo sapiens
24 ANKRD36 375248
Affinity Capture-MS Homo sapiens
25 USHBP1  
Two-hybrid Homo sapiens
26 ATG16L1 55054
Affinity Capture-MS Homo sapiens
27 KRT83  
Two-hybrid Homo sapiens
28 VPS53 55275
Affinity Capture-MS Homo sapiens
29 ZWINT  
Affinity Capture-MS Homo sapiens
30 FBXW5  
Two-hybrid Homo sapiens
31 EXOC3 11336
Affinity Capture-MS Homo sapiens
32 EEA1 8411
Affinity Capture-MS Homo sapiens
33 SPAG5 10615
Affinity Capture-MS Homo sapiens
34 AQP1 358
Two-hybrid Homo sapiens
35 LMNA 4000
Affinity Capture-MS Homo sapiens
36 MCC 4163
Affinity Capture-MS Homo sapiens
37 PIBF1  
Affinity Capture-MS Homo sapiens
38 FAM110A  
Two-hybrid Homo sapiens
39 TRIM24  
Affinity Capture-MS Homo sapiens
40 CEP152  
Affinity Capture-MS Homo sapiens
41 TXLNG  
Affinity Capture-MS Homo sapiens
42 KIF5A 3798
Affinity Capture-MS Homo sapiens
43 KRT75 9119
Two-hybrid Homo sapiens
44 C17orf70  
Affinity Capture-MS Homo sapiens
45 TRIM32 22954
Affinity Capture-MS Homo sapiens
46 PKN1 5585
Two-hybrid Homo sapiens
47 VCPIP1 80124
Affinity Capture-MS Homo sapiens
48 LINC00238  
Two-hybrid Homo sapiens
49 ATG12  
Affinity Capture-MS Homo sapiens
50 KRT85  
Two-hybrid Homo sapiens
51 DISC1 27185
Affinity Capture-MS Homo sapiens
52 GAN 8139
Affinity Capture-MS Homo sapiens
53 KRT3 3850
Two-hybrid Homo sapiens
54 GOLGA3 2802
Affinity Capture-MS Homo sapiens
55 CEP63  
Affinity Capture-MS Homo sapiens
56 KRT86  
Two-hybrid Homo sapiens
57 TXLNB  
Two-hybrid Homo sapiens
58 ZC4H2 55906
Affinity Capture-MS Homo sapiens
59 DES 1674
Two-hybrid Homo sapiens
60 SPECC1 92521
Affinity Capture-MS Homo sapiens
61 HOOK3 84376
Affinity Capture-MS Homo sapiens
62 HOXA1 3198
Two-hybrid Homo sapiens
63 OTX1  
Two-hybrid Homo sapiens
64 GNG13  
Two-hybrid Homo sapiens
65 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
66 KRT81  
Two-hybrid Homo sapiens
67 MTG1  
Two-hybrid Homo sapiens
68 NEFM 4741
Affinity Capture-MS Homo sapiens
69 RABGAP1 23637
Affinity Capture-MS Homo sapiens
70 BEND3  
Affinity Capture-MS Homo sapiens
71 NSMCE4A  
Affinity Capture-MS Homo sapiens
72 PPFIA1 8500
Affinity Capture-MS Homo sapiens
73 MPHOSPH9  
Affinity Capture-MS Homo sapiens
74 SASS6 163786
Affinity Capture-MS Homo sapiens
75 PSMC3IP  
Affinity Capture-MS Homo sapiens
76 BCAS2 10286
Two-hybrid Homo sapiens
77 RUFY3  
Affinity Capture-MS Homo sapiens
78 HSF4  
Two-hybrid Homo sapiens
79 C21orf58  
Two-hybrid Homo sapiens
80 TBC1D21 161514
Two-hybrid Homo sapiens
81 CCDC102A 92922
Affinity Capture-MS Homo sapiens
82 PIN1 5300
Two-hybrid Homo sapiens
83 NUFIP2 57532
Two-hybrid Homo sapiens
84 NDNL2 56160
Affinity Capture-MS Homo sapiens
85 THAP11 57215
Affinity Capture-MS Homo sapiens
86 KRT71 112802
Two-hybrid Homo sapiens
87 PSMA1 5682
Two-hybrid Homo sapiens
88 KRT6C 286887
Two-hybrid Homo sapiens
89 KRT74 121391
Two-hybrid Homo sapiens
90 KXD1 79036
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KRT37 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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