Gene description for VCPIP1
Gene name valosin containing protein (p97)/p47 complex interacting protein 1
Gene symbol VCPIP1
Other names/aliases DUBA3
VCIP135
Species Homo sapiens
 Database cross references - VCPIP1
ExoCarta ExoCarta_80124
Entrez Gene 80124
HGNC 30897
MIM 611745
UniProt Q96JH7  
 VCPIP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Thymus 23844026    
 Gene ontology annotations for VCPIP1
Molecular Function
    ubiquitin-specific protease activity GO:0004843 ISS
Biological Process
    protein K48-linked deubiquitination GO:0071108 IDA
    endoplasmic reticulum membrane fusion GO:0016320 IEA
    protein ubiquitination GO:0016567 ISS
    protein K11-linked deubiquitination GO:0035871 IDA
    mitotic nuclear division GO:0007067 IEA
    Golgi reassembly GO:0090168 IEA
Subcellular Localization
    Golgi stack GO:0005795 IEA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IEA
 Experiment description of studies that identified VCPIP1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VCPIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NSFL1C 55968
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
2 VCP 7415
Invivo Homo sapiens
Invitro Homo sapiens
3 STX5A  
Invitro Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which VCPIP1 is involved
No pathways found





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