Gene description for FIGNL1
Gene name fidgetin-like 1
Gene symbol FIGNL1
Other names/aliases -
Species Homo sapiens
 Database cross references - FIGNL1
ExoCarta ExoCarta_63979
Vesiclepedia VP_63979
Entrez Gene 63979
HGNC 13286
MIM 615383
UniProt Q6PIW4  
 FIGNL1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Urine 19056867    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for FIGNL1
Molecular Function
    magnesium ion binding GO:0000287 ISS
    DNA clamp loader activity GO:0003689 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    microtubule severing ATPase activity GO:0008568 IBA
    hydrolase activity GO:0016787 ISS
    ATP hydrolysis activity GO:0016887 IBA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IEA
    osteoblast differentiation GO:0001649 ISS
    chromatin remodeling GO:0006338 IEA
    male meiotic nuclear division GO:0007140 ISS
    regulation of double-strand break repair via homologous recombination GO:0010569 IDA
    osteoblast proliferation GO:0033687 ISS
    negative regulation of apoptotic process GO:0043066 ISS
    ATP metabolic process GO:0046034 ISS
    regulation of cell cycle GO:0051726 ISS
    cellular response to ionizing radiation GO:0071479 IDA
    chromatin looping GO:0140588 IEA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IEA
Subcellular Localization
    nuclear chromosome GO:0000228 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FIGNL1 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
3
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FIGNL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 LYZL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GYPA  
Affinity Capture-MS Homo sapiens
4 MIF 4282
Affinity Capture-MS Homo sapiens
5 TNXB 7148
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 HSPA1L 3305
Co-fractionation Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 PRKY  
Affinity Capture-MS Homo sapiens
10 AVIL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 POTEI 653269
Affinity Capture-MS Homo sapiens
12 C1orf186  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TMEM25  
Affinity Capture-MS Homo sapiens
14 HN1L 90861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 VCPIP1 80124
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CD6 923
Affinity Capture-MS Homo sapiens
17 ITGB1BP1 9270
Two-hybrid Homo sapiens
18 TDRD3  
Affinity Capture-MS Homo sapiens
19 KCNS3 3790
Affinity Capture-MS Homo sapiens
20 Chaf1a  
Affinity Capture-MS Mus musculus
21 TKT 7086
Affinity Capture-MS Homo sapiens
22 RHOT2 89941
Proximity Label-MS Homo sapiens
23 DUSP16  
Affinity Capture-MS Homo sapiens
24 ZC3H11A  
Affinity Capture-MS Homo sapiens
25 C1orf112  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 AARSD1 80755
Affinity Capture-MS Homo sapiens
27 FAM84A  
Affinity Capture-MS Homo sapiens
28 THAP11 57215
Affinity Capture-MS Homo sapiens
29 NCAPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CLEC12B  
Affinity Capture-MS Homo sapiens
31 KCNE3  
Affinity Capture-MS Homo sapiens
32 LYZL1  
Affinity Capture-MS Homo sapiens
33 KDM1A 23028
Two-hybrid Homo sapiens
34 GCC1 79571
Two-hybrid Homo sapiens
35 RPA3 6119
Proximity Label-MS Homo sapiens
36 NTRK1 4914
Affinity Capture-MS Homo sapiens
37 AZU1 566
Affinity Capture-MS Homo sapiens
38 GFPT2 9945
Affinity Capture-MS Homo sapiens
39 RFXANK  
Affinity Capture-MS Homo sapiens
40 CALD1 800
Affinity Capture-MS Homo sapiens
41 DDRGK1 65992
Affinity Capture-MS Homo sapiens
42 F9 2158
Affinity Capture-MS Homo sapiens
43 NUDT14 256281
Affinity Capture-MS Homo sapiens
44 SEMA4C 54910
Affinity Capture-MS Homo sapiens
45 TSC22D3  
Affinity Capture-MS Homo sapiens
46 RABL2A 11159
Affinity Capture-MS Homo sapiens
47 RAD51  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TNFRSF1B  
Affinity Capture-MS Homo sapiens
49 NCKAP5  
Affinity Capture-MS Homo sapiens
50 PLA2G10  
Affinity Capture-MS Homo sapiens
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