Gene description for AARSD1
Gene name alanyl-tRNA synthetase domain containing 1
Gene symbol AARSD1
Other names/aliases -
Species Homo sapiens
 Database cross references - AARSD1
ExoCarta ExoCarta_80755
Vesiclepedia VP_80755
Entrez Gene 80755
HGNC 28417
MIM 613212
UniProt Q9BTE6  
 AARSD1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for AARSD1
Molecular Function
    Ser-tRNA(Ala) hydrolase activity GO:0002196 IBA
    molecular_function GO:0003674 ND
    nucleic acid binding GO:0003676 IEA
    alanine-tRNA ligase activity GO:0004813 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    alanyl-tRNA aminoacylation GO:0006419 IEA
    regulation of translational fidelity GO:0006450 IBA
    biological_process GO:0008150 ND
    aminoacyl-tRNA metabolism involved in translational fidelity GO:0106074 IEA
Subcellular Localization
    nucleus GO:0005634 HDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified AARSD1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AARSD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 DDHD2 23259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 DPPA3  
Affinity Capture-MS Homo sapiens
4 HOOK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DERL2 51009
Affinity Capture-MS Homo sapiens
6 FBXO7 25793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ALMS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TPD52L2 7165
Co-fractionation Homo sapiens
9 TRIP13 9319
Affinity Capture-MS Homo sapiens
10 SH3GL1 6455
Co-fractionation Homo sapiens
11 MARCH7  
Affinity Capture-MS Homo sapiens
12 LAP3 51056
Co-fractionation Homo sapiens
13 WNK1 65125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TAB1 10454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SEPT2 4735
Co-fractionation Homo sapiens
16 SBDS 51119
Co-fractionation Homo sapiens
17 DNAJB6 10049
Affinity Capture-MS Homo sapiens
18 PPP1R12A 4659
Co-fractionation Homo sapiens
19 TBCB 1155
Co-fractionation Homo sapiens
20 DYRK1A 1859
Affinity Capture-MS Homo sapiens
21 APAF1 317
Affinity Capture-MS Homo sapiens
22 BORA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 UBL4B  
Affinity Capture-MS Homo sapiens
24 HAUS6  
Affinity Capture-MS Homo sapiens
25 SERPINH1 871
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
26 MED22  
Affinity Capture-MS Homo sapiens
27 PEAK1 79834
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FIGNL1 63979
Affinity Capture-MS Homo sapiens
29 ELP4  
Affinity Capture-MS Homo sapiens
30 CALR 811
Co-fractionation Homo sapiens
31 MECP2 4204
Affinity Capture-MS Homo sapiens
32 NIF3L1 60491
Co-fractionation Homo sapiens
33 NPHP3 27031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DYNLT1 6993
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
35 ERCC6L 54821
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 IRS4 8471
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
37 HPS5 11234
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ARPC2 10109
Co-fractionation Homo sapiens
39 USP10 9100
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 LUZP1 7798
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 QPRT 23475
Affinity Capture-MS Homo sapiens
42 STIL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 TUBA1A 7846
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
44 BRCA2 675
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 UBXN1 51035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 FUBP1 8880
Co-fractionation Homo sapiens
47 GDPD5 81544
Affinity Capture-MS Homo sapiens
48 OGT 8473
Reconstituted Complex Homo sapiens
49 JADE2 23338
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 RGS20 8601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PYCRL 65263
Affinity Capture-MS Homo sapiens
52 CREB3  
Affinity Capture-MS Homo sapiens
53 THG1L 54974
Co-fractionation Homo sapiens
54 GNA13 10672
Affinity Capture-MS Homo sapiens
55 RPS14P3  
Affinity Capture-MS Homo sapiens
56 HECTD1 25831
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ARPC5 10092
Co-fractionation Homo sapiens
58 PRKAR1B  
Affinity Capture-MS Homo sapiens
59 PPP1R14B 26472
Co-fractionation Homo sapiens
60 RHOJ 57381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 SEPT8 23176
Co-fractionation Homo sapiens
62 RAD21 5885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 TXK  
Affinity Capture-MS Homo sapiens
64 TAT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 S100P 6286
Affinity Capture-MS Homo sapiens
66 RPL23 9349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 UBQLN2 29978
Co-fractionation Homo sapiens
68 RICTOR 253260
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 MAP3K7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 SASS6 163786
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 GTF2E1 2960
Co-fractionation Homo sapiens
72 EFTUD2 9343
Co-fractionation Homo sapiens
73 PRKACA 5566
Co-fractionation Homo sapiens
74 C12orf74  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 RPA3 6119
Co-fractionation Homo sapiens
76 TRAPPC4 51399
Affinity Capture-MS Homo sapiens
77 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 TP53RK 112858
Co-fractionation Homo sapiens
79 SH3GLB2 56904
Co-fractionation Homo sapiens
80 PFDN5 5204
Co-fractionation Homo sapiens
81 PPP2CB 5516
Co-fractionation Homo sapiens
82 NCAPG 64151
Affinity Capture-MS Homo sapiens
83 ARPC1A 10552
Co-fractionation Homo sapiens
84 KIF1A 547
Affinity Capture-MS Homo sapiens
85 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
86 TTC1 7265
Co-fractionation Homo sapiens
87 ALKBH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 SSFA2 6744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 PARVG 64098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 RIC8B 55188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 TRIM45  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 TRMT10A 93587
Co-fractionation Homo sapiens
93 CALU 813
Co-fractionation Homo sapiens
94 RPA1 6117
Co-fractionation Homo sapiens
95 MLF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 PFDN1 5201
Co-fractionation Homo sapiens
97 HSPB1 3315
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
98 EIF4A3 9775
Affinity Capture-MS Homo sapiens
99 FAM83H 286077
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 RPUSD2  
Co-fractionation Homo sapiens
101 TARS 6897
Co-fractionation Homo sapiens
102 XPO5 57510
Co-fractionation Homo sapiens
103 SH3GLB1 51100
Co-fractionation Homo sapiens
104 HARS 3035
Co-fractionation Homo sapiens
105 YKT6 10652
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 RPRD1B 58490
Co-fractionation Homo sapiens
107 SRM 6723
Co-fractionation Homo sapiens
108 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 POC5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which AARSD1 is involved
No pathways found





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