Gene description for TRIP13
Gene name thyroid hormone receptor interactor 13
Gene symbol TRIP13
Other names/aliases 16E1BP
Species Homo sapiens
 Database cross references - TRIP13
ExoCarta ExoCarta_9319
Entrez Gene 9319
HGNC 12307
MIM 604507
UniProt Q15645  
 TRIP13 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for TRIP13
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 NAS
    identical protein binding GO:0042802 IPI
    transcription cofactor activity GO:0003712 TAS
Biological Process
    spermatogenesis GO:0007283 ISS
    oogenesis GO:0048477 ISS
    synaptonemal complex assembly GO:0007130 ISS
    male meiosis I GO:0007141 IEA
    double-strand break repair GO:0006302 ISS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    spermatid development GO:0007286 IEA
    regulation of nucleic acid-templated transcription GO:1903506 TAS
    reciprocal meiotic recombination GO:0007131 ISS
    female meiosis I GO:0007144 IEA
    oocyte maturation GO:0001556 IEA
Subcellular Localization
    male germ cell nucleus GO:0001673 IEA
    nucleus GO:0005634 TAS
 Experiment description of studies that identified TRIP13 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRIP13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GALT  
Two-hybrid Homo sapiens
2 TRIP13 9319
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 FLJ10204  
Two-hybrid Homo sapiens
4 CARD14  
Two-hybrid Homo sapiens
5 PBLD 64081
Two-hybrid Homo sapiens
6 LNX  
Two-hybrid Homo sapiens
7 NIF3L1 60491
Two-hybrid Homo sapiens
8 HDHD3  
Two-hybrid Homo sapiens
9 C11orf54 28970
Two-hybrid Homo sapiens
10 RBPMS  
Two-hybrid Homo sapiens
11 DTX2  
Two-hybrid Homo sapiens
12 PLSCR4  
Two-hybrid Homo sapiens
13 SEMA4G  
Two-hybrid Homo sapiens
14 PLAC8  
Two-hybrid Homo sapiens
15 ASB13  
Two-hybrid Homo sapiens
16 MAD2L1BP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
17 SIGLEC5  
Two-hybrid Homo sapiens
18 ARL11  
Two-hybrid Homo sapiens
19 PARK2  
Two-hybrid Homo sapiens
20 LOXL4 84171
Two-hybrid Homo sapiens
21 ADAM15 8751
Two-hybrid Homo sapiens
22 PLSCR3 57048
Two-hybrid Homo sapiens
23 SEC24A 10802
Two-hybrid Homo sapiens
24 CYB5R2 51700
Two-hybrid Homo sapiens
25 FLJ25369  
Two-hybrid Homo sapiens
26 NME4  
Two-hybrid Homo sapiens
27 KIAA1609  
Two-hybrid Homo sapiens
28 SELENBP1 8991
Two-hybrid Homo sapiens
29 KIAA0514  
Two-hybrid Homo sapiens
30 GLYCTK  
Two-hybrid Homo sapiens
31 PPP2CA 5515
Two-hybrid Homo sapiens
32 ZNF655  
Two-hybrid Homo sapiens
33 LASP1 3927
Two-hybrid Homo sapiens
34 AMSH-LP  
Two-hybrid Homo sapiens
35 DDAH2  
Two-hybrid Homo sapiens
36 CRMP1 1400
Two-hybrid Homo sapiens
37 KRTAP3-2  
Two-hybrid Homo sapiens
38 CPSF3L 54973
Two-hybrid Homo sapiens
39 PLK3  
Two-hybrid Homo sapiens
40 COMT 1312
Two-hybrid Homo sapiens
41 GPSM1  
Two-hybrid Homo sapiens
42 SMUG1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRIP13 is involved
No pathways found





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