Gene description for NME4
Gene name NME/NM23 nucleoside diphosphate kinase 4
Gene symbol NME4
Other names/aliases NDPK-D
NM23H4
nm23-H4
Species Homo sapiens
 Database cross references - NME4
ExoCarta ExoCarta_4833
Vesiclepedia VP_4833
Entrez Gene 4833
HGNC 7852
MIM 601818
UniProt O00746  
 NME4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NME4
Molecular Function
    ATP binding GO:0005524 IEA
    protein complex binding GO:0032403 IEA
    lipid binding GO:0008289 IEA
    metal ion binding GO:0046872 IEA
    nucleoside diphosphate kinase activity GO:0004550 EXP
    protein binding GO:0005515 IPI
Biological Process
    lipid transport GO:0006869 IEA
    CTP biosynthetic process GO:0006241 IEA
    nucleoside diphosphate phosphorylation GO:0006165 IEA
    UTP biosynthetic process GO:0006228 IEA
    pyrimidine nucleotide metabolic process GO:0006220 IBA
    nucleoside triphosphate biosynthetic process GO:0009142 IBA
    nucleoside metabolic process GO:0009116 TAS
    regulation of apoptotic process GO:0042981 IBA
    purine nucleotide metabolic process GO:0006163 IBA
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    small molecule metabolic process GO:0044281 TAS
    nucleobase-containing small molecule interconversion GO:0015949 TAS
    GTP biosynthetic process GO:0006183 IEA
Subcellular Localization
    cytosol GO:0005829 IBA
    mitochondrial inner membrane GO:0005743 TAS
    intracellular GO:0005622 IBA
    mitochondrial intermembrane space GO:0005758 IEA
    mitochondrion GO:0005739 TAS
    mitochondrial matrix GO:0005759 IEA
 Experiment description of studies that identified NME4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NME4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NME4 4833
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 NME1 4830
Two-hybrid Homo sapiens
3 TRIP13 9319
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NME4 is involved
PathwayEvidenceSource
Synthesis and interconversion of nucleotide di- and triphosphates TAS Reactome





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