Gene description for NME4
Gene name NME/NM23 nucleoside diphosphate kinase 4
Gene symbol NME4
Other names/aliases NDPK-D
NM23H4
nm23-H4
Species Homo sapiens
 Database cross references - NME4
ExoCarta ExoCarta_4833
Vesiclepedia VP_4833
Entrez Gene 4833
HGNC 7852
MIM 601818
UniProt O00746  
 NME4 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NME4
Molecular Function
    nucleoside diphosphate kinase activity GO:0004550 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    cardiolipin binding GO:1901612 IDA
Biological Process
    GTP biosynthetic process GO:0006183 IEA
    UTP biosynthetic process GO:0006228 IEA
    CTP biosynthetic process GO:0006241 IEA
    lipid transport GO:0006869 IDA
    nucleoside metabolic process GO:0009116 TAS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 TAS
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrial matrix GO:0005759 IEA
 Experiment description of studies that identified NME4 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NME4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 TRAPPC2 6399
Two-hybrid Homo sapiens
3 GLRX5 51218
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 SLIRP 81892
Proximity Label-MS Homo sapiens
6 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
7 CABP2  
Two-hybrid Homo sapiens
8 PAXIP1  
Affinity Capture-MS Homo sapiens
9 TPP1 1200
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TRUB2  
Proximity Label-MS Homo sapiens
11 MTG2  
Proximity Label-MS Homo sapiens
12 NGRN  
Proximity Label-MS Homo sapiens
13 ITGB8 3696
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CBWD2  
Affinity Capture-MS Homo sapiens
15 TRAPPC2B  
Two-hybrid Homo sapiens
16 CD79A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DNAJC15  
Proximity Label-MS Homo sapiens
18 MTRF1  
Proximity Label-MS Homo sapiens
19 GFM2 84340
Proximity Label-MS Homo sapiens
20 CCDC90B  
Proximity Label-MS Homo sapiens
21 ARMC7  
Two-hybrid Homo sapiens
22 APEX1 328
Affinity Capture-RNA Homo sapiens
23 LRP1 4035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ATPAF2 91647
Two-hybrid Homo sapiens
25 MCU 90550
Proximity Label-MS Homo sapiens
26 CRYZ 1429
Proximity Label-MS Homo sapiens
27 TFAM 7019
Proximity Label-MS Homo sapiens
28 PMPCA 23203
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 C8orf82  
Proximity Label-MS Homo sapiens
30 NME7 29922
Two-hybrid Homo sapiens
31 CHCHD2  
Affinity Capture-MS Homo sapiens
32 CIB3  
Two-hybrid Homo sapiens
33 HINT2 84681
Proximity Label-MS Homo sapiens
34 COL8A1 1295
Affinity Capture-MS Homo sapiens
35 CPA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 CIDEB  
Two-hybrid Homo sapiens
37 MRPS26 64949
Proximity Label-MS Homo sapiens
38 SURF1  
Proximity Label-MS Homo sapiens
39 EXD2  
Proximity Label-MS Homo sapiens
40 LACTB 114294
Affinity Capture-MS Homo sapiens
41 CABP5  
Two-hybrid Homo sapiens
42 NME2 4831
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
43 SOCS3 9021
Two-hybrid Homo sapiens
44 TIMM50 92609
Affinity Capture-MS Homo sapiens
45 PMPCB 9512
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 TACO1  
Proximity Label-MS Homo sapiens
47 FASTKD2  
Proximity Label-MS Homo sapiens
48 VWA8 23078
Proximity Label-MS Homo sapiens
49 LMO4  
Two-hybrid Homo sapiens
50 MTERF3  
Proximity Label-MS Homo sapiens
51 ACP6 51205
Affinity Capture-MS Homo sapiens
52 POLR1C 9533
Two-hybrid Homo sapiens
53 MDH2 4191
Proximity Label-MS Homo sapiens
54 TUFM 7284
Proximity Label-MS Homo sapiens
55 TMEM25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 C6orf203  
Proximity Label-MS Homo sapiens
57 FASTKD5  
Proximity Label-MS Homo sapiens
58 ZBTB16  
Two-hybrid Homo sapiens
59 TUB  
Affinity Capture-MS Homo sapiens
60 NT5DC2 64943
Affinity Capture-MS Homo sapiens
61 MUTYH  
Affinity Capture-MS Homo sapiens
62 VSIG4  
Affinity Capture-MS Homo sapiens
63 HTT 3064
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Luminescence Homo sapiens
64 C14orf119  
Two-hybrid Homo sapiens
65 HSCB 150274
Proximity Label-MS Homo sapiens
66 ABHD11 83451
Affinity Capture-MS Homo sapiens
67 CCDC109B 55013
Proximity Label-MS Homo sapiens
68 POLDIP2 26073
Affinity Capture-MS Homo sapiens
69 MOV10 4343
Affinity Capture-RNA Homo sapiens
70 NME3 4832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 CIB1 10519
Two-hybrid Homo sapiens
72 MTFMT  
Proximity Label-MS Homo sapiens
73 MRPL11 65003
Proximity Label-MS Homo sapiens
74 MTRF1L  
Proximity Label-MS Homo sapiens
75 TSSK3  
Two-hybrid Homo sapiens
76 TMEM70  
Proximity Label-MS Homo sapiens
77 C6orf165  
Two-hybrid Homo sapiens
78 USP32 84669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 TRIP13 9319
Two-hybrid Homo sapiens
80 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 ECH1 1891
Affinity Capture-MS Homo sapiens
82 OTC 5009
Proximity Label-MS Homo sapiens
83 LSM8 51691
Two-hybrid Homo sapiens
84 MRRF  
Proximity Label-MS Homo sapiens
85 MRPS12  
Proximity Label-MS Homo sapiens
86 MTIF2 4528
Proximity Label-MS Homo sapiens
87 PITRM1 10531
Affinity Capture-MS Homo sapiens
88 NME1-NME2 654364
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
89 TNFSF8  
Affinity Capture-MS Homo sapiens
90 MTIF3  
Proximity Label-MS Homo sapiens
91 CCDC57 284001
Two-hybrid Homo sapiens
92 CPA2  
Affinity Capture-MS Homo sapiens
93 MMP26  
Affinity Capture-MS Homo sapiens
94 CD274 29126
Affinity Capture-MS Homo sapiens
95 COX6A1  
Affinity Capture-MS Homo sapiens
96 DHX30 22907
Proximity Label-MS Homo sapiens
97 UBL5 59286
Two-hybrid Homo sapiens
98 NXF1 10482
Affinity Capture-RNA Homo sapiens
Two-hybrid Homo sapiens
99 GATC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 C12orf65  
Proximity Label-MS Homo sapiens
101 ABTB2 25841
Affinity Capture-MS Homo sapiens
102 RPUSD4 84881
Proximity Label-MS Homo sapiens
103 NRD1 4898
Affinity Capture-MS Homo sapiens
104 NME1 4830
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
105 ATP5E 514
Affinity Capture-MS Homo sapiens
106 SCGB2A2  
Affinity Capture-MS Homo sapiens
107 SUV39H2 79723
Two-hybrid Homo sapiens
108 TSFM 10102
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 ACAD9 28976
Proximity Label-MS Homo sapiens
110 DDRGK1 65992
Affinity Capture-MS Homo sapiens
111 BMI1  
Affinity Capture-MS Homo sapiens
112 CDKN2D  
Two-hybrid Homo sapiens
113 HSPA9 3313
Proximity Label-MS Homo sapiens
114 METTL15  
Proximity Label-MS Homo sapiens
115 CCDC102B  
Two-hybrid Homo sapiens
116 PFDN5 5204
Affinity Capture-MS Homo sapiens
117 MCUR1 63933
Proximity Label-MS Homo sapiens
118 PROSC 11212
Affinity Capture-MS Homo sapiens
119 CLPP 8192
Proximity Label-MS Homo sapiens
120 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
121 C17orf80 55028
Proximity Label-MS Homo sapiens
122 NUTF2 10204
Two-hybrid Homo sapiens
123 TERF2  
Affinity Capture-MS Homo sapiens
124 AUH 549
Proximity Label-MS Homo sapiens
125 TBRG4 9238
Proximity Label-MS Homo sapiens
126 DNAJC19 131118
Proximity Label-MS Homo sapiens
127 TP53 7157
Affinity Capture-MS Homo sapiens
128 TSPYL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 ICT1 3396
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
130 NME4 4833
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
131 ISOC2  
Affinity Capture-MS Homo sapiens
132 LRPPRC 10128
Proximity Label-MS Homo sapiens
133 PDHA1 5160
Proximity Label-MS Homo sapiens
134 GOLPH3 64083
Affinity Capture-MS Homo sapiens
135 MKRN3  
Two-hybrid Homo sapiens
136 COX8A  
Proximity Label-MS Homo sapiens
137 C21orf33  
Proximity Label-MS Homo sapiens
138 SSBP1 6742
Proximity Label-MS Homo sapiens
139 FASTKD3  
Proximity Label-MS Homo sapiens
140 ABI2 10152
Two-hybrid Homo sapiens
141 LONP1 9361
Proximity Label-MS Homo sapiens
142 GFM1 85476
Proximity Label-MS Homo sapiens
143 AARS2  
Proximity Label-MS Homo sapiens
144 ABHD10 55347
Affinity Capture-MS Homo sapiens
145 TEFM  
Proximity Label-MS Homo sapiens
146 C1orf109  
Two-hybrid Homo sapiens
147 MIPEP  
Affinity Capture-MS Homo sapiens
148 RPUSD3  
Proximity Label-MS Homo sapiens
149 GRSF1 2926
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
150 C1QBP 708
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 OXCT2  
Affinity Capture-MS Homo sapiens
152 CYCS 54205
Affinity Capture-MS Homo sapiens
153 METTL17  
Proximity Label-MS Homo sapiens
154 HSF2BP  
Two-hybrid Homo sapiens
155 YBEY  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 DDX28  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NME4 is involved
PathwayEvidenceSource
Interconversion of nucleotide di- and triphosphates TAS Reactome
Metabolism TAS Reactome
Metabolism of nucleotides TAS Reactome





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