Gene description for PITRM1
Gene name pitrilysin metallopeptidase 1
Gene symbol PITRM1
Other names/aliases MP1
PreP
Species Homo sapiens
 Database cross references - PITRM1
ExoCarta ExoCarta_10531
Entrez Gene 10531
HGNC 17663
UniProt Q5JRX3  
 PITRM1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PITRM1
Molecular Function
    enzyme activator activity GO:0008047 TAS
    metal ion binding GO:0046872 IEA
    metalloendopeptidase activity GO:0004222 IMP
Biological Process
    positive regulation of catalytic activity GO:0043085 TAS
    proteolysis GO:0006508 IMP
Subcellular Localization
    mitochondrial matrix GO:0005759 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified PITRM1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PITRM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PITRM1 is involved
No pathways found





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