Experiment description of studies that identified NAV3 in sEVs

1 Experiment ID 497 MISEV standards ✘ Biophysical techniques ✔ CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1 Enriched markers ✘ Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35931686     Organism Homo sapiens Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD." Journal name Cell Death Dis Publication year 2022 Sample Chondrocytes Sample name T/C-28a2 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

2 Experiment ID 498 MISEV standards ✔ EM Biophysical techniques ✔ CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1 Enriched markers ✘ Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 35931686     Organism Homo sapiens Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD." Journal name Cell Death Dis Publication year 2022 Sample Chondrocytes Sample name T/C-28a2 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

3 Experiment ID 488 MISEV standards ✔ EM Biophysical techniques ✔ CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 36408942     Organism Homo sapiens Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." Journal name Proteomics Publication year 2023 Sample Mesenchymal stem cells Sample name UCMSC Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

Protein-protein interactions for NAV3

Protein Interactor ExoCarta ID Identification method PubMed Species 1 TUBA3C 7278 Affinity Capture-MS Homo sapiens 2 NAV2   Affinity Capture-MS Homo sapiens 3 MAPRE1 22919 Affinity Capture-Western Homo sapiens 4 PDX1   Affinity Capture-MS Homo sapiens 5 VPS9D1   Affinity Capture-MS Homo sapiens 6 APC   Two-hybrid Homo sapiens 7 RNF41   Affinity Capture-MS Homo sapiens 8 TRIO 7204 Affinity Capture-Western Homo sapiens 9 TFAP4 7023 Affinity Capture-MS Homo sapiens 10 KIF20A 10112 Affinity Capture-MS Homo sapiens 11 KDM3A   Affinity Capture-MS Homo sapiens 12 PITRM1 10531 Affinity Capture-MS Homo sapiens 13 HIST1H3A 8350 Cross-Linking-MS (XL-MS) Homo sapiens 14 CUX2 23316 Affinity Capture-MS Homo sapiens 15 TRIM21 6737 Affinity Capture-MS Homo sapiens 16 KIF14 9928 Affinity Capture-MS Homo sapiens 17 ING5   Affinity Capture-MS Homo sapiens 18 HSPA1A 3303 Cross-Linking-MS (XL-MS) Homo sapiens 19 HSPA8 3312 Cross-Linking-MS (XL-MS) Homo sapiens 20 ECT2 1894 Affinity Capture-MS Homo sapiens 21 SOX2   Affinity Capture-MS Homo sapiens View the network

Pathways in which NAV3 is involved

No pathways found