Gene description for CUX2
Gene name cut-like homeobox 2
Gene symbol CUX2
Other names/aliases CDP2
CUTL2
Species Homo sapiens
 Database cross references - CUX2
ExoCarta ExoCarta_23316
Vesiclepedia VP_23316
Entrez Gene 23316
HGNC 19347
MIM 610648
UniProt O14529  
 CUX2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CUX2
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 ISS
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IEA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    short-term memory GO:0007614 ISS
    positive regulation of gene expression GO:0010628 ISS
    positive regulation of dendrite morphogenesis GO:0050775 ISS
    cognition GO:0050890 IMP
    positive regulation of synapse assembly GO:0051965 ISS
    positive regulation of dendritic spine morphogenesis GO:0061003 ISS
    positive regulation of excitatory postsynaptic potential GO:2000463 ISS
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CUX2 in exosomes
1
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CUX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NAV3 89795
Affinity Capture-MS Homo sapiens
2 CUX1 1523
Affinity Capture-MS Homo sapiens
3 SNX2 6643
Affinity Capture-MS Homo sapiens
4 KPNA4 3840
Affinity Capture-MS Homo sapiens
5 WDR45B 56270
Affinity Capture-MS Homo sapiens
6 KPNA3 3839
Affinity Capture-MS Homo sapiens
7 TMCO1 54499
Cross-Linking-MS (XL-MS) Homo sapiens
8 SNX5 27131
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CUX2 is involved
No pathways found





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