Gene description for CUX2
Gene name cut-like homeobox 2
Gene symbol CUX2
Other names/aliases CDP2
CUTL2
Species Homo sapiens
 Database cross references - CUX2
ExoCarta ExoCarta_23316
Entrez Gene 23316
HGNC 19347
MIM 610648
UniProt O14529  
 CUX2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CUX2
Molecular Function
    sequence-specific DNA binding GO:0043565 IDA
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 ISS
Biological Process
    short-term memory GO:0007614 ISS
    cognition GO:0050890 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    positive regulation of dendrite morphogenesis GO:0050775 ISS
    positive regulation of dendritic spine morphogenesis GO:0061003 ISS
    positive regulation of gene expression GO:0010628 ISS
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 ISS
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of synapse assembly GO:0051965 ISS
    cellular response to organic substance GO:0071310 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified CUX2 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CUX2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CUX2 is involved
No pathways found





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