Gene description for CUX1
Gene name cut-like homeobox 1
Gene symbol CUX1
Other names/aliases CASP
CDP
CDP/Cut
CDP1
COY1
CUTL1
CUX
Clox
Cux/CDP
GOLIM6
Nbla10317
p100
p110
p200
p75
Species Homo sapiens
 Database cross references - CUX1
ExoCarta ExoCarta_1523
Vesiclepedia VP_1523
Entrez Gene 1523
HGNC 2557
MIM 116896
UniProt Q13948   P39880  
 CUX1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CUX1
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 ISS
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    intra-Golgi vesicle-mediated transport GO:0006891 IEA
    positive regulation of dendrite morphogenesis GO:0050775 ISS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified CUX1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CUX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CHRNA4  
Affinity Capture-MS Homo sapiens
3 RAB1A 5861
Affinity Capture-MS Homo sapiens
4 FEV  
Proximity Label-MS Homo sapiens
5 HDAC1 3065
Affinity Capture-MS Homo sapiens
6 SACM1L 22908
Affinity Capture-MS Homo sapiens
7 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 FOXD3  
Affinity Capture-MS Homo sapiens
9 FMR1 2332
Affinity Capture-MS Homo sapiens
10 BTF3 689
Affinity Capture-MS Homo sapiens
11 NFATC1 4772
Affinity Capture-MS Homo sapiens
12 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
13 GATA2  
Proximity Label-MS Homo sapiens
14 EN1  
Proximity Label-MS Homo sapiens
15 RECQL5  
Two-hybrid Homo sapiens
16 NIT1 4817
Co-fractionation Homo sapiens
17 SOX9  
Proximity Label-MS Homo sapiens
18 TNFSF18 8995
Affinity Capture-MS Homo sapiens
19 SOX2  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 CENPA  
Proximity Label-MS Homo sapiens
21 RB1CC1 9821
Affinity Capture-MS Homo sapiens
22 APEX1 328
Proximity Label-MS Homo sapiens
23 Cenpf  
Affinity Capture-MS Mus musculus
24 TFAM 7019
Proximity Label-MS Homo sapiens
25 CTNNB1 1499
Affinity Capture-MS Homo sapiens
26 NDUFB8 4714
Affinity Capture-MS Homo sapiens
27 WDR83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 CUX1 1523
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
29 COA3 28958
Affinity Capture-MS Homo sapiens
30 ZNF512B  
Affinity Capture-MS Homo sapiens
31 GPRC5B 51704
Affinity Capture-MS Homo sapiens
32 P2RY8  
Affinity Capture-MS Homo sapiens
33 JTB 10899
Affinity Capture-MS Homo sapiens
34 HIST1H3A 8350
Proximity Label-MS Homo sapiens
35 ATP2A3 489
Affinity Capture-MS Homo sapiens
36 C3orf52  
Affinity Capture-MS Homo sapiens
37 CDK7 1022
Reconstituted Complex Homo sapiens
38 STX6 10228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 KLF4  
Proximity Label-MS Homo sapiens
40 F2RL1  
Affinity Capture-MS Homo sapiens
41 BET1 10282
Affinity Capture-MS Homo sapiens
42 CUL1 8454
Affinity Capture-MS Homo sapiens
43 ASF1A 25842
Proximity Label-MS Homo sapiens
44 EBAG9 9166
Proximity Label-MS Homo sapiens
45 PTH1R  
Affinity Capture-MS Homo sapiens
46 TMEM59 9528
Affinity Capture-MS Homo sapiens
47 RBPJ 3516
Affinity Capture-MS Homo sapiens
48 FOXP1 27086
Affinity Capture-MS Homo sapiens
49 RAB1B 81876
Affinity Capture-MS Homo sapiens
50 RB1 5925
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
51 LHX3  
Proximity Label-MS Homo sapiens
52 SYCE1  
Affinity Capture-MS Homo sapiens
53 LPAR2 9170
Affinity Capture-MS Homo sapiens
54 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
55 TLX3  
Proximity Label-MS Homo sapiens
56 MAGEA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ERGIC2 51290
Proximity Label-MS Homo sapiens
58 TEAD1  
Proximity Label-MS Homo sapiens
59 NFIX 4784
Proximity Label-MS Homo sapiens
60 Ar  
Affinity Capture-MS Mus musculus
61 CBX3 11335
Proximity Label-MS Homo sapiens
62 RAB30 27314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CCNB1 891
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
64 PBXIP1 57326
Affinity Capture-MS Homo sapiens
65 LHX2  
Proximity Label-MS Homo sapiens
66 NTRK1 4914
Affinity Capture-MS Homo sapiens
67 FOXK2  
Affinity Capture-MS Homo sapiens
68 TNFRSF9  
Affinity Capture-MS Homo sapiens
69 GPR182  
Affinity Capture-MS Homo sapiens
70 ITM2C 81618
Affinity Capture-MS Homo sapiens
71 NUP62 23636
Affinity Capture-MS Homo sapiens
72 CLSTN2 64084
Affinity Capture-MS Homo sapiens
73 SRF  
Affinity Capture-MS Homo sapiens
74 RPA4  
Proximity Label-MS Homo sapiens
75 T  
Proximity Label-MS Homo sapiens
76 CEBPA  
Proximity Label-MS Homo sapiens
77 BIN1 274
Two-hybrid Homo sapiens
78 POTEB3 102724631
Affinity Capture-MS Homo sapiens
79 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
80 TLX2  
Proximity Label-MS Homo sapiens
81 GAN 8139
Affinity Capture-MS Homo sapiens
82 PAX6  
Proximity Label-MS Homo sapiens
83 SPATS2L 26010
Affinity Capture-MS Homo sapiens
84 CXCR4 7852
Affinity Capture-MS Homo sapiens
85 TTYH1  
Affinity Capture-MS Homo sapiens
86 SKP2  
Affinity Capture-MS Homo sapiens
87 KCND3 3752
Affinity Capture-Western Homo sapiens
88 TP53BP1 7158
Affinity Capture-MS Homo sapiens
89 SOX6  
Proximity Label-MS Homo sapiens
90 ILKAP 80895
Affinity Capture-MS Homo sapiens
91 ECT2 1894
Affinity Capture-MS Homo sapiens
92 ZDHHC12  
Affinity Capture-MS Homo sapiens
93 LAMP1 3916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 FOXO1  
Affinity Capture-MS Homo sapiens
95 CHRNA1  
Affinity Capture-MS Homo sapiens
96 FOXG1  
Affinity Capture-MS Homo sapiens
97 NR3C1 2908
Proximity Label-MS Homo sapiens
98 CLEC4A  
Affinity Capture-MS Homo sapiens
99 ELAC2 60528
Two-hybrid Homo sapiens
100 FOXL1  
Proximity Label-MS Homo sapiens
101 SUMO2 6613
Reconstituted Complex Homo sapiens
102 SOX15  
Proximity Label-MS Homo sapiens
103 HNF4A  
Proximity Label-MS Homo sapiens
104 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 ATP2A1 487
Affinity Capture-MS Homo sapiens
106 ACKR2  
Affinity Capture-MS Homo sapiens
107 EHMT2 10919
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
108 CCNA1  
Reconstituted Complex Homo sapiens
109 SOX5 6660
Proximity Label-MS Homo sapiens
110 FOXQ1  
Affinity Capture-MS Homo sapiens
111 LPPR2  
Affinity Capture-MS Homo sapiens
112 MYB  
Proximity Label-MS Homo sapiens
113 SATB1 6304
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
114 TACC3  
Affinity Capture-MS Homo sapiens
115 TLX1  
Proximity Label-MS Homo sapiens
116 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
117 PARP1 142
Proximity Label-MS Homo sapiens
118 MYOD1  
Proximity Label-MS Homo sapiens
119 GABRE  
Affinity Capture-MS Homo sapiens
120 GP9 2815
Affinity Capture-MS Homo sapiens
121 MAX  
Two-hybrid Homo sapiens
122 SIDT2 51092
Affinity Capture-MS Homo sapiens
123 C3AR1  
Affinity Capture-MS Homo sapiens
124 TMEM68  
Affinity Capture-MS Homo sapiens
125 FOXJ2  
Affinity Capture-MS Homo sapiens
126 KAT2B  
Biochemical Activity Homo sapiens
127 FOXE1  
Affinity Capture-MS Homo sapiens
128 TSPAN15 23555
Affinity Capture-MS Homo sapiens
129 SOX4  
Proximity Label-MS Homo sapiens
130 B4GAT1 11041
Affinity Capture-MS Homo sapiens
131 CREBBP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
132 FOXN1  
Affinity Capture-MS Homo sapiens
133 IL3RA  
Affinity Capture-MS Homo sapiens
134 CDK1 983
Biochemical Activity Homo sapiens
135 TLE4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
136 PCNA 5111
Co-fractionation Homo sapiens
137 ANAPC2 29882
Proximity Label-MS Homo sapiens
138 CUX2 23316
Affinity Capture-MS Homo sapiens
139 NUP50 10762
Proximity Label-MS Homo sapiens
140 EXT2 2132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 LRRC61 65999
Affinity Capture-MS Homo sapiens
142 PINK1  
Affinity Capture-MS Homo sapiens
143 CIT 11113
Affinity Capture-MS Homo sapiens
144 KXD1 79036
Affinity Capture-MS Homo sapiens
145 HNF1B  
Proximity Label-MS Homo sapiens
146 NFIC 4782
Proximity Label-MS Homo sapiens
147 AR 367
Proximity Label-MS Homo sapiens
148 Tpi1 21991
Affinity Capture-MS Mus musculus
149 FBXO38 81545
Proximity Label-MS Homo sapiens
150 SP7  
Proximity Label-MS Homo sapiens
151 CAV1 857
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CUX1 is involved
No pathways found





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