Gene description for SUMO2
Gene name small ubiquitin-like modifier 2
Gene symbol SUMO2
Other names/aliases HSMT3
SMT3B
SMT3H2
SUMO3
Smt3A
Species Homo sapiens
 Database cross references - SUMO2
ExoCarta ExoCarta_6613
Entrez Gene 6613
HGNC 11125
MIM 603042
UniProt P61956  
 SUMO2 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
 Gene ontology annotations for SUMO2
Molecular Function
    protein binding GO:0005515 IPI
    SUMO transferase activity GO:0019789 IEA
    poly(A) RNA binding GO:0044822 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
Biological Process
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IDA
    cellular protein metabolic process GO:0044267 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    protein sumoylation GO:0016925 TAS
    post-translational protein modification GO:0043687 TAS
Subcellular Localization
    nucleus GO:0005634 IDA
    PML body GO:0016605 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified SUMO2 in exosomes
1
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
2
Experiment ID 274
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for SUMO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SENP3  
Two-hybrid Homo sapiens
2 HDAC4  
Invivo Homo sapiens
Invitro Homo sapiens
3 UBE2I 7329
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
4 VIM 7431
Two-hybrid Homo sapiens
5 CHD3  
Two-hybrid Homo sapiens
6 PML  
Affinity Capture-MS Homo sapiens
7 RANGAP1 5905
Affinity Capture-MS Homo sapiens
8 TRIM63  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 MAF1  
Two-hybrid Homo sapiens
10 SUMO2 6613
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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