Gene description for CEP78
Gene name centrosomal protein 78kDa
Gene symbol CEP78
Other names/aliases C9orf81
IP63
Species Homo sapiens
 Database cross references - CEP78
ExoCarta ExoCarta_84131
Vesiclepedia VP_84131
Entrez Gene 84131
HGNC 25740
UniProt Q5JTW2  
 CEP78 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CEP78
Biological Process
    flagellated sperm motility GO:0030317 IMP
    negative regulation of protein ubiquitination GO:0031397 IDA
    cilium organization GO:0044782 IBA
    cilium organization GO:0044782 IMP
    cilium organization GO:0044782 ISS
    protein localization to cilium GO:0061512 ISS
    protein localization to centrosome GO:0071539 IDA
Subcellular Localization
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    centrosome GO:0005813 IDA
    centriole GO:0005814 IDA
    cytosol GO:0005829 TAS
    ciliary basal body GO:0036064 IBA
    ciliary basal body GO:0036064 IDA
 Experiment description of studies that identified CEP78 in exosomes
1
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CEP78
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FTL 2512
Affinity Capture-MS Homo sapiens
2 NAP1L4 4676
Affinity Capture-MS Homo sapiens
3 CALR 811
Affinity Capture-MS Homo sapiens
4 LLGL2 3993
Affinity Capture-MS Homo sapiens
5 PER2  
Affinity Capture-MS Homo sapiens
6 TMEM182  
Affinity Capture-MS Homo sapiens
7 CACNG5  
Affinity Capture-MS Homo sapiens
8 IPO5 3843
Affinity Capture-MS Homo sapiens
9 CACNG7  
Affinity Capture-MS Homo sapiens
10 NXF1 10482
Affinity Capture-RNA Homo sapiens
11 SOD1 6647
Affinity Capture-MS Homo sapiens
12 MARCKS 4082
Affinity Capture-MS Homo sapiens
13 XPO1 7514
Affinity Capture-MS Homo sapiens
14 KCNE3  
Affinity Capture-MS Homo sapiens
15 RC3H2  
Affinity Capture-MS Homo sapiens
16 SH3BP4 23677
Two-hybrid Homo sapiens
17 PDIA4 9601
Affinity Capture-MS Homo sapiens
18 MCC 4163
Affinity Capture-MS Homo sapiens
19 EFNB1 1947
Affinity Capture-MS Homo sapiens
20 LCE3D  
Affinity Capture-MS Homo sapiens
21 CDH5  
Affinity Capture-MS Homo sapiens
22 VPRBP 9730
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
23 UFL1 23376
Affinity Capture-MS Homo sapiens
24 CEP350 9857
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
25 ASPM 259266
Affinity Capture-MS Homo sapiens
26 CD6 923
Affinity Capture-MS Homo sapiens
27 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
28 TRIM33 51592
Affinity Capture-MS Homo sapiens
29 SQSTM1 8878
Affinity Capture-MS Homo sapiens
30 PDIA3 2923
Affinity Capture-MS Homo sapiens
31 HSPB1 3315
Two-hybrid Homo sapiens
32 ZNF324B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 DLK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FUS 2521
Affinity Capture-MS Homo sapiens
35 SUMO2 6613
Affinity Capture-MS Homo sapiens
36 IKZF1  
Affinity Capture-MS Homo sapiens
37 TMEM74  
Affinity Capture-MS Homo sapiens
38 LTBR 4055
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CALM1 801
Affinity Capture-MS Homo sapiens
40 MLEC 9761
Affinity Capture-MS Homo sapiens
41 SLC16A6 9120
Affinity Capture-MS Homo sapiens
42 STT3A 3703
Affinity Capture-MS Homo sapiens
43 TRIM24  
Affinity Capture-MS Homo sapiens
44 RPS28 6234
Affinity Capture-MS Homo sapiens
45 CEP250 11190
Affinity Capture-MS Homo sapiens
46 Cep72  
Affinity Capture-MS Mus musculus
47 FBXW7  
Affinity Capture-MS Homo sapiens
48 EEF2KMT  
Affinity Capture-MS Homo sapiens
49 MOV10 4343
Affinity Capture-RNA Homo sapiens
50 BRD4 23476
Affinity Capture-MS Homo sapiens
51 KCTD17 79734
Affinity Capture-MS Homo sapiens
52 CTNNB1 1499
Affinity Capture-MS Homo sapiens
53 HECTD1 25831
Affinity Capture-MS Homo sapiens
54 TPM3 7170
Affinity Capture-MS Homo sapiens
55 PCGF6  
Affinity Capture-MS Homo sapiens
56 ARRDC3 57561
Affinity Capture-MS Homo sapiens
57 SSSCA1 10534
Affinity Capture-MS Homo sapiens
58 PNMA2  
Affinity Capture-MS Homo sapiens
59 Cep78  
Affinity Capture-MS Mus musculus
60 PPP2CA 5515
Affinity Capture-MS Homo sapiens
61 CLEC11A 6320
Affinity Capture-MS Homo sapiens
62 DPP7 29952
Affinity Capture-MS Homo sapiens
63 DDB1 1642
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 STMN1 3925
Affinity Capture-MS Homo sapiens
65 DDRGK1 65992
Affinity Capture-MS Homo sapiens
66 EIF2B5 8893
Affinity Capture-MS Homo sapiens
67 Fgfr1op  
Affinity Capture-MS Mus musculus
68 KBTBD4  
Affinity Capture-MS Homo sapiens
69 YWHAG 7532
Affinity Capture-MS Homo sapiens
70 ZNF331  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 Mad2l1 56150
Affinity Capture-MS Mus musculus
72 SYT12  
Affinity Capture-MS Homo sapiens
73 CREB3  
Affinity Capture-MS Homo sapiens
74 Cep120  
Affinity Capture-MS Mus musculus
75 Prkar2a 19087
Affinity Capture-MS Mus musculus
76 RIPK4  
Affinity Capture-MS Homo sapiens
77 SLC7A6 9057
Affinity Capture-MS Homo sapiens
78 PASK  
Affinity Capture-MS Homo sapiens
79 TRAK1 22906
Affinity Capture-MS Homo sapiens
80 FGFR1OP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 ALDOA 226
Affinity Capture-MS Homo sapiens
82 PIPSL 266971
Affinity Capture-MS Homo sapiens
83 Ubr5  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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