Gene description for ASPM
Gene name asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
Gene symbol ASPM
Other names/aliases ASP
Calmbp1
MCPH5
Species Homo sapiens
 Database cross references - ASPM
ExoCarta ExoCarta_259266
Entrez Gene 259266
HGNC 19048
MIM 605481
UniProt Q8IZT6  
 ASPM identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for ASPM
Molecular Function
    calmodulin binding GO:0005516 IEA
Biological Process
    oogenesis GO:0048477 IEA
    spindle assembly involved in meiosis GO:0090306 IEA
    neuronal stem cell maintenance GO:0097150 IEA
    negative regulation of asymmetric cell division GO:0045769 IEA
    forebrain neuroblast division GO:0021873 IEA
    cerebral cortex development GO:0021987 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IEA
    neuron migration GO:0001764 IEA
    negative regulation of neuron differentiation GO:0045665 IEA
    developmental growth GO:0048589 IEA
    spermatogenesis GO:0007283 IEA
    mitotic nuclear division GO:0007067 IEA
    positive regulation of neuroblast proliferation GO:0002052 IEA
    male gonad development GO:0008584 IEA
    maintenance of centrosome location GO:0051661 IEA
Subcellular Localization
    meiotic spindle GO:0072687 IEA
    midbody GO:0030496 IEA
    microtubule GO:0005874 IEA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IEA
    mitotic spindle pole GO:0097431 IEA
 Experiment description of studies that identified ASPM in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for ASPM
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ASPM is involved
No pathways found





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