Gene description for MTOR
Gene name	mechanistic target of rapamycin (serine/threonine kinase)
Gene symbol	MTOR
Other names/aliases	FRAP FRAP1 FRAP2 RAFT1 RAPT1
Species	Homo sapiens
Database cross references - MTOR
ExoCarta	ExoCarta_2475
Entrez Gene	2475
HGNC	3942
MIM	601231
UniProt	P42345
MTOR identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for MTOR

Molecular Function     protein serine/threonine kinase activity GO:0004674 TAS     protein binding GO:0005515 IPI     TFIIIC-class transcription factor binding GO:0001156 IDA     ATP binding GO:0005524 IEA     RNA polymerase III type 1 promoter DNA binding GO:0001030 IDA     drug binding GO:0008144 IEA     RNA polymerase III type 3 promoter DNA binding GO:0001032 IDA     RNA polymerase III type 2 promoter DNA binding GO:0001031 IDA     kinase activity GO:0016301 TAS     ribosome binding GO:0043022 IEA     protein dimerization activity GO:0046983 IBA     phosphoprotein binding GO:0051219 IPI     protein domain specific binding GO:0019904 IEA Biological Process     positive regulation of gene expression GO:0010628 IMP     positive regulation of lipid biosynthetic process GO:0046889 IMP     regulation of fatty acid beta-oxidation GO:0031998 IEA     cellular response to hypoxia GO:0071456 ISS     protein autophosphorylation GO:0046777 IDA     response to amino acid GO:0043200 IDA     regulation of myelination GO:0031641 IEA     cellular response to heat GO:0034605 TAS     cell cycle arrest GO:0007050 TAS     regulation of actin cytoskeleton organization GO:0032956 IMP     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     phosphorylation GO:0016310 IDA     double-strand break repair via homologous recombination GO:0000724 IBA     negative regulation of macroautophagy GO:0016242 IEA     protein catabolic process GO:0030163 TAS     regulation of osteoclast differentiation GO:0045670 ISS     negative regulation of NFAT protein import into nucleus GO:0051534 IEA     negative regulation of mitochondrion degradation GO:1903147 NAS     regulation of glycogen biosynthetic process GO:0005979 IEA     regulation of cellular response to heat GO:1900034 TAS     cellular response to nutrient levels GO:0031669 ISS     growth GO:0040007 NAS     positive regulation of endothelial cell proliferation GO:0001938 IEA     positive regulation of stress fiber assembly GO:0051496 IEA     regulation of carbohydrate utilization GO:0043610 IEA     protein phosphorylation GO:0006468 IMP     insulin receptor signaling pathway GO:0008286 TAS     positive regulation of translation GO:0045727 IDA     positive regulation of protein phosphorylation GO:0001934 IDA     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     positive regulation of protein kinase B signaling GO:0051897 IEA     positive regulation of actin filament polymerization GO:0030838 IEA     response to stress GO:0006950 IMP     positive regulation of myotube differentiation GO:0010831 IEA     peptidyl-serine phosphorylation GO:0018105 IMP     Fc-epsilon receptor signaling pathway GO:0038095 TAS     response to nutrient GO:0007584 NAS     innate immune response GO:0045087 TAS     germ cell development GO:0007281 IEA     gene expression GO:0010467 TAS     positive regulation of transcription from RNA polymerase III promoter GO:0045945 IMP     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     regulation of response to food GO:0032095 IEA     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     TOR signaling GO:0031929 IMP     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     peptidyl-threonine phosphorylation GO:0018107 IEA     T cell costimulation GO:0031295 TAS     positive regulation of lamellipodium assembly GO:0010592 IEA     signal transduction GO:0007165 NAS     negative regulation of cell size GO:0045792 IEA     cell growth GO:0016049 TAS     ruffle organization GO:0031529 IEA     negative regulation of autophagy GO:0010507 ISS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     regulation of protein kinase activity GO:0045859 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS Subcellular Localization     cytoplasm GO:0005737 IDA     phosphatidylinositol 3-kinase complex GO:0005942 NAS     Golgi membrane GO:0000139 IEA     PML body GO:0016605 ISS     lysosomal membrane GO:0005765 IDA     TORC1 complex GO:0031931 IMP     lysosome GO:0005764 IDA     cytosol GO:0005829 TAS     TORC2 complex GO:0031932 IDA     dendrite GO:0030425 IEA     neuronal cell body GO:0043025 IEA     endomembrane system GO:0012505 IDA     mitochondrial outer membrane GO:0005741 IEA     endoplasmic reticulum membrane GO:0005789 IEA     nucleoplasm GO:0005654 TAS     membrane GO:0016020 IDA