Gene description for CMKLR1
Gene name chemerin chemokine-like receptor 1
Gene symbol CMKLR1
Other names/aliases CHEMERINR
ChemR23
DEZ
RVER1
Species Homo sapiens
 Database cross references - CMKLR1
ExoCarta ExoCarta_1240
Vesiclepedia VP_1240
Entrez Gene 1240
HGNC 2121
MIM 602351
UniProt Q99788  
 CMKLR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CMKLR1
Molecular Function
    complement receptor activity GO:0004875 IBA
    G protein-coupled receptor activity GO:0004930 IBA
    G protein-coupled receptor activity GO:0004930 NAS
    chemokine receptor activity GO:0004950 TAS
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 TAS
    adipokinetic hormone receptor activity GO:0097003 IDA
    adipokinetic hormone binding GO:0097004 IDA
Biological Process
    skeletal system development GO:0001501 TAS
    complement receptor mediated signaling pathway GO:0002430 IBA
    chemotaxis GO:0006935 IBA
    chemotaxis GO:0006935 IDA
    inflammatory response GO:0006954 IBA
    immune response GO:0006955 TAS
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    G protein-coupled receptor signaling pathway GO:0007186 NAS
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IBA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IBA
    positive regulation of macrophage chemotaxis GO:0010759 IBA
    positive regulation of macrophage chemotaxis GO:0010759 IMP
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    negative regulation of interleukin-12 production GO:0032695 ISS
    positive regulation of fat cell differentiation GO:0045600 ISS
    regulation of calcium-mediated signaling GO:0050848 IBA
    regulation of calcium-mediated signaling GO:0050848 IDA
    chemokine-mediated signaling pathway GO:0070098 IEA
    positive regulation of cold-induced thermogenesis GO:0120162 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 NAS
 Experiment description of studies that identified CMKLR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CMKLR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DPY19L1 23333
Affinity Capture-MS Homo sapiens
2 ABCC4 10257
Affinity Capture-MS Homo sapiens
3 SACM1L 22908
Affinity Capture-MS Homo sapiens
4 TFB2M  
Affinity Capture-MS Homo sapiens
5 CCDC132 55610
Affinity Capture-MS Homo sapiens
6 KIAA2013 90231
Affinity Capture-MS Homo sapiens
7 ROBO1 6091
Affinity Capture-MS Homo sapiens
8 TMEM186  
Affinity Capture-MS Homo sapiens
9 INTS1 26173
Affinity Capture-MS Homo sapiens
10 PTDSS2 81490
Affinity Capture-MS Homo sapiens
11 MCU 90550
Affinity Capture-MS Homo sapiens
12 ELOVL2  
Affinity Capture-MS Homo sapiens
13 NR2F2  
Affinity Capture-MS Homo sapiens
14 YIPF3 25844
Affinity Capture-MS Homo sapiens
15 GPRC5B 51704
Affinity Capture-MS Homo sapiens
16 C10orf35  
Affinity Capture-MS Homo sapiens
17 HELLS 3070
Affinity Capture-MS Homo sapiens
18 C20orf24  
Affinity Capture-MS Homo sapiens
19 SLC25A46 91137
Affinity Capture-MS Homo sapiens
20 VPS53 55275
Affinity Capture-MS Homo sapiens
21 BTAF1 9044
Affinity Capture-MS Homo sapiens
22 CST1  
Affinity Capture-MS Homo sapiens
23 ADCK4 79934
Affinity Capture-MS Homo sapiens
24 EXOC5 10640
Affinity Capture-MS Homo sapiens
25 TMEM87A 25963
Affinity Capture-MS Homo sapiens
26 DGAT1 8694
Affinity Capture-MS Homo sapiens
27 PDS5B 23047
Affinity Capture-MS Homo sapiens
28 FASTKD1  
Affinity Capture-MS Homo sapiens
29 CST2  
Affinity Capture-MS Homo sapiens
30 VKORC1L1 154807
Affinity Capture-MS Homo sapiens
31 SC5D 6309
Affinity Capture-MS Homo sapiens
32 SFXN3 81855
Affinity Capture-MS Homo sapiens
33 FADS1 3992
Affinity Capture-MS Homo sapiens
34 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
35 EXOC4 60412
Affinity Capture-MS Homo sapiens
36 CERS2 29956
Affinity Capture-MS Homo sapiens
37 PDXDC1 23042
Affinity Capture-MS Homo sapiens
38 UBAC2 337867
Affinity Capture-MS Homo sapiens
39 PDS5A 23244
Affinity Capture-MS Homo sapiens
40 ATP9A 10079
Affinity Capture-MS Homo sapiens
41 LEMD2 221496
Affinity Capture-MS Homo sapiens
42 OPA1 4976
Affinity Capture-MS Homo sapiens
43 EXOC6 54536
Affinity Capture-MS Homo sapiens
44 NOMO3 408050
Affinity Capture-MS Homo sapiens
45 ATP2B4 493
Affinity Capture-MS Homo sapiens
46 TIMELESS  
Affinity Capture-MS Homo sapiens
47 ST3GAL3  
Affinity Capture-MS Homo sapiens
48 GNL3L 54552
Affinity Capture-MS Homo sapiens
49 OXA1L  
Affinity Capture-MS Homo sapiens
50 SLC25A24 29957
Affinity Capture-MS Homo sapiens
51 FANCD2  
Affinity Capture-MS Homo sapiens
52 TARBP1 6894
Affinity Capture-MS Homo sapiens
53 ATP2B2 491
Affinity Capture-MS Homo sapiens
54 TVP23C  
Affinity Capture-MS Homo sapiens
55 STXBP1 6812
Affinity Capture-MS Homo sapiens
56 FITM2  
Affinity Capture-MS Homo sapiens
57 ATRIP  
Affinity Capture-MS Homo sapiens
58 TMEM11 8834
Affinity Capture-MS Homo sapiens
59 NAT14 57106
Affinity Capture-MS Homo sapiens
60 WAPAL  
Affinity Capture-MS Homo sapiens
61 SGPP1 81537
Affinity Capture-MS Homo sapiens
62 TM9SF3 56889
Affinity Capture-MS Homo sapiens
63 AMY1C 278
Affinity Capture-MS Homo sapiens
64 SLC35B2 347734
Affinity Capture-MS Homo sapiens
65 ZW10 9183
Affinity Capture-MS Homo sapiens
66 TMEM259 91304
Affinity Capture-MS Homo sapiens
67 CST4 1472
Affinity Capture-MS Homo sapiens
68 FAM134C 162427
Affinity Capture-MS Homo sapiens
69 STXBP2 6813
Affinity Capture-MS Homo sapiens
70 JAK1 3716
Affinity Capture-MS Homo sapiens
71 TMCO1 54499
Affinity Capture-MS Homo sapiens
72 MTOR 2475
Affinity Capture-MS Homo sapiens
73 DOLK 22845
Affinity Capture-MS Homo sapiens
74 CERS6  
Affinity Capture-MS Homo sapiens
75 KIAA0368 23392
Affinity Capture-MS Homo sapiens
76 KIDINS220 57498
Affinity Capture-MS Homo sapiens
77 PEX3 8504
Affinity Capture-MS Homo sapiens
78 SLC19A2 10560
Affinity Capture-MS Homo sapiens
79 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
80 GPR89A  
Affinity Capture-MS Homo sapiens
81 EXOC3 11336
Affinity Capture-MS Homo sapiens
82 COQ5  
Affinity Capture-MS Homo sapiens
83 VPS52 6293
Affinity Capture-MS Homo sapiens
84 ATL2 64225
Affinity Capture-MS Homo sapiens
85 XPR1 9213
Affinity Capture-MS Homo sapiens
86 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
87 DNAAF5 54919
Affinity Capture-MS Homo sapiens
88 INTS2  
Affinity Capture-MS Homo sapiens
89 UNC93B1 81622
Affinity Capture-MS Homo sapiens
90 AUP1 550
Affinity Capture-MS Homo sapiens
91 C19orf52  
Affinity Capture-MS Homo sapiens
92 DNM3 26052
Affinity Capture-MS Homo sapiens
93 AGPAT6 137964
Affinity Capture-MS Homo sapiens
94 SIGMAR1 10280
Affinity Capture-MS Homo sapiens
95 MTX3  
Affinity Capture-MS Homo sapiens
96 CNIH4  
Affinity Capture-MS Homo sapiens
97 CCRN4L  
Affinity Capture-MS Homo sapiens
98 ECSIT 51295
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CMKLR1 is involved
PathwayEvidenceSource
Class A/1 (Rhodopsin-like receptors) TAS Reactome
GPCR ligand binding TAS Reactome
Signal Transduction TAS Reactome
Signaling by GPCR TAS Reactome





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