Gene description for EXOC6
Gene name exocyst complex component 6
Gene symbol EXOC6
Other names/aliases EXOC6A
SEC15
SEC15L
SEC15L1
SEC15L3
Sec15p
Species Homo sapiens
 Database cross references - EXOC6
ExoCarta ExoCarta_54536
Vesiclepedia VP_54536
Entrez Gene 54536
HGNC 23196
MIM 609672
UniProt Q8TAG9  
 EXOC6 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for EXOC6
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    mitotic cytokinesis GO:0000281 NAS
    intracellular protein transport GO:0006886 IEA
    exocytosis GO:0006887 IBA
    Golgi to plasma membrane transport GO:0006893 IBA
    vesicle docking involved in exocytosis GO:0006904 NAS
    membrane fission GO:0090148 NAS
    vesicle tethering involved in exocytosis GO:0090522 NAS
Subcellular Localization
    exocyst GO:0000145 IBA
    exocyst GO:0000145 NAS
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 TAS
    growth cone GO:0030426 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    Flemming body GO:0090543 IEA
 Experiment description of studies that identified EXOC6 in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EXOC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DSN1 79980
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 APP 351
Two-hybrid Homo sapiens
3 CYP2C8  
Two-hybrid Homo sapiens
4 BTNL9  
Affinity Capture-MS Homo sapiens
5 IMMT 10989
Affinity Capture-MS Homo sapiens
6 C5AR2  
Affinity Capture-MS Homo sapiens
7 C9orf89 84270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 EXOC7 23265
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PTH1R  
Affinity Capture-MS Homo sapiens
14 CXCR4 7852
Affinity Capture-MS Homo sapiens
15 VPS53 55275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 EXOC5 10640
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 MAS1  
Affinity Capture-MS Homo sapiens
18 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 EXOC3 11336
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 EXOC8 149371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
21 FPR1  
Affinity Capture-MS Homo sapiens
22 EXOC2 55770
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 NOS3  
Two-hybrid Homo sapiens
24 NPTN 27020
Affinity Capture-MS Homo sapiens
25 GCDH 2639
Two-hybrid Homo sapiens
26 ALB 213
Affinity Capture-MS Homo sapiens
27 PRDX2 7001
Two-hybrid Homo sapiens
28 CMKLR1 1240
Affinity Capture-MS Homo sapiens
29 NAE1 8883
Co-fractionation Homo sapiens
30 GNAQ 2776
Affinity Capture-MS Homo sapiens
31 NPY2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 CUL3 8452
Affinity Capture-MS Homo sapiens
33 NR3C1 2908
Proximity Label-MS Homo sapiens
34 EFNB1 1947
Affinity Capture-MS Homo sapiens
35 RNF32  
Two-hybrid Homo sapiens
36 EGFR 1956
Affinity Capture-MS Homo sapiens
37 MYO5A 4644
Affinity Capture-Western Homo sapiens
38 RAP1A 5906
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 LOXL4 84171
Two-hybrid Homo sapiens
40 STX11 8676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PSEN2 5664
Two-hybrid Homo sapiens
42 IL1R2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PSMD14 10213
Affinity Capture-MS Homo sapiens
44 EXOC4 60412
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CD80 941
Affinity Capture-MS Homo sapiens
46 RAB8A 4218
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
47 SLC18A2  
Affinity Capture-MS Homo sapiens
48 DTNBP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 GPR17 2840
Affinity Capture-MS Homo sapiens
50 VIPR2  
Affinity Capture-MS Homo sapiens
51 C3orf18  
Affinity Capture-MS Homo sapiens
52 RPA3 6119
Proximity Label-MS Homo sapiens
53 STX3 6809
Affinity Capture-Western Homo sapiens
54 HECTD1 25831
Affinity Capture-MS Homo sapiens
55 NTRK1 4914
Affinity Capture-MS Homo sapiens
56 MYO5B 4645
Affinity Capture-Western Homo sapiens
57 TBC1D30 23329
Affinity Capture-Western Homo sapiens
58 RAB11A 8766
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
59 GPR182  
Affinity Capture-MS Homo sapiens
60 EXOC6 54536
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 FAM174A 345757
Affinity Capture-MS Homo sapiens
62 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 EXOC6B 23233
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 P2RY10  
Affinity Capture-MS Homo sapiens
66 XRCC3  
Affinity Capture-MS Homo sapiens
67 GYPA  
Affinity Capture-MS Homo sapiens
68 SEMA4C 54910
Affinity Capture-MS Homo sapiens
69 MAST1  
Two-hybrid Homo sapiens
70 EXOSC1 51013
Two-hybrid Homo sapiens
71 TACSTD2 4070
Affinity Capture-MS Homo sapiens
72 ECSIT 51295
Two-hybrid Homo sapiens
73 ITFG3 83986
Affinity Capture-MS Homo sapiens
74 SAMM50 25813
Affinity Capture-MS Homo sapiens
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