Gene description for EXOSC1
Gene name exosome component 1
Gene symbol EXOSC1
Other names/aliases CGI-108
CSL4
Csl4p
SKI4
Ski4p
hCsl4p
p13
Species Homo sapiens
 Database cross references - EXOSC1
ExoCarta ExoCarta_51013
Vesiclepedia VP_51013
Entrez Gene 51013
HGNC 17286
MIM 606493
UniProt Q9Y3B2  
 EXOSC1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for EXOSC1
Molecular Function
    RNA binding GO:0003723 NAS
    RNA exonuclease activity GO:0004532 IDA
    protein binding GO:0005515 IPI
Biological Process
    rRNA processing GO:0006364 IEA
    RNA processing GO:0006396 IDA
    RNA catabolic process GO:0006401 IDA
Subcellular Localization
    nuclear exosome (RNase complex) GO:0000176 IBA
    nuclear exosome (RNase complex) GO:0000176 NAS
    cytoplasmic exosome (RNase complex) GO:0000177 NAS
    exosome (RNase complex) GO:0000178 IDA
    exosome (RNase complex) GO:0000178 NAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    nucleolar exosome (RNase complex) GO:0101019 NAS
 Experiment description of studies that identified EXOSC1 in exosomes
1
Experiment ID 207
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
MISEV standards
EM
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
MISEV standards
Biophysical techniques
TSG101|HSP70|FLOT1
Enriched markers
VDAC
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EXOSC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 EXOSC7 23016
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 EXOSC3 51010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
6 KCTD10 83892
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 REL 5966
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 TEX11  
Two-hybrid Homo sapiens
9 RNF32  
Two-hybrid Homo sapiens
10 EIF4E2  
Affinity Capture-MS Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
12 WDR36 134430
Affinity Capture-MS Homo sapiens
13 USP36  
Affinity Capture-MS Homo sapiens
14 Lsm3  
Two-hybrid Mus musculus
15 RPS20 6224
Affinity Capture-MS Homo sapiens
16 NCOR1  
Affinity Capture-MS Homo sapiens
17 Ddx3x 13205
Two-hybrid Mus musculus
18 SKIV2L2 23517
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DYRK1A 1859
Affinity Capture-MS Homo sapiens
20 WDR83  
Two-hybrid Homo sapiens
21 METTL22  
Affinity Capture-MS Homo sapiens
22 CPSF7 79869
Two-hybrid Homo sapiens
23 ASB9  
Two-hybrid Homo sapiens
24 A2M 2
Two-hybrid Homo sapiens
25 EXOSC4 54512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ATG16L1 55054
Affinity Capture-MS Homo sapiens
27 EXOSC6 118460
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MPHOSPH6 10200
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 EXOSC9 5393
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 DMRTB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
31 DIS3L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SRP9 6726
Affinity Capture-MS Homo sapiens
33 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
34 FHL3 2275
Two-hybrid Homo sapiens
35 RPL9 6133
Affinity Capture-MS Homo sapiens
36 XRN1 54464
Two-hybrid Homo sapiens
37 RBM7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 EXOSC5 56915
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 RPL27A 6157
Affinity Capture-MS Homo sapiens
40 ZFC3H1 196441
Affinity Capture-MS Homo sapiens
41 SRPK3  
Affinity Capture-MS Homo sapiens
42 RPS15A 6210
Affinity Capture-MS Homo sapiens
43 PTAR1 375743
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 BAG3 9531
Affinity Capture-MS Homo sapiens
Affinity Capture-Luminescence Homo sapiens
45 ZCCHC8 55596
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 HBS1L 10767
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 BAZ1B 9031
Affinity Capture-MS Homo sapiens
48 NOS3  
Two-hybrid Homo sapiens
49 RFC2 5982
Affinity Capture-MS Homo sapiens
50 Rbm14  
Two-hybrid Mus musculus
51 ZNF143  
Two-hybrid Homo sapiens
52 SF1 7536
Two-hybrid Homo sapiens
53 EXOC6 54536
Two-hybrid Homo sapiens
54 EIF2S2 8894
Affinity Capture-MS Homo sapiens
55 GIGYF2 26058
Affinity Capture-MS Homo sapiens
56 LSM3 27258
Two-hybrid Homo sapiens
57 DIS3 22894
Affinity Capture-MS Homo sapiens
58 SH3GLB2 56904
Two-hybrid Homo sapiens
59 DDRGK1 65992
Affinity Capture-MS Homo sapiens
60 KRAS 3845
Negative Genetic Homo sapiens
61 UPF2 26019
Two-hybrid Homo sapiens
62 RPS16 6217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 EXOSC10 5394
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
65 FASN 2194
Positive Genetic Homo sapiens
Negative Genetic Homo sapiens
66 NUP160 23279
Two-hybrid Homo sapiens
67 RPS25 6230
Affinity Capture-MS Homo sapiens
68 PARP1 142
Affinity Capture-MS Homo sapiens
69 PAK7  
Two-hybrid Homo sapiens
70 CDC37 11140
Two-hybrid Homo sapiens
71 THOP1 7064
Affinity Capture-MS Homo sapiens
72 RPS4X 6191
Affinity Capture-MS Homo sapiens
73 MORF4L2  
Affinity Capture-MS Homo sapiens
74 TBL3 10607
Affinity Capture-MS Homo sapiens
75 DDIT4L  
Two-hybrid Homo sapiens
76 PRRC2B  
Two-hybrid Homo sapiens
77 C1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 TCF4  
Two-hybrid Homo sapiens
79 RPL17 6139
Affinity Capture-MS Homo sapiens
80 KCTD1 284252
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
81 EXOSC2 23404
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 BTBD9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 MAST1  
Two-hybrid Homo sapiens
84 NSUN5  
Affinity Capture-MS Homo sapiens
85 EXOSC8  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
86 ECSIT 51295
Two-hybrid Homo sapiens
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