Gene description for EXOSC7
Gene name exosome component 7
Gene symbol EXOSC7
Other names/aliases EAP1
Species Homo sapiens
 Database cross references - EXOSC7
ExoCarta ExoCarta_23016
Entrez Gene 23016
HGNC 28112
MIM 606488
UniProt Q15024  
 EXOSC7 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for EXOSC7
Molecular Function
    RNA binding GO:0003723 TAS
    protein binding GO:0005515 IPI
    3'-5'-exoribonuclease activity GO:0000175 TAS
    exoribonuclease activity GO:0004532 IDA
Biological Process
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    rRNA processing GO:0006364 TAS
    RNA catabolic process GO:0006401 NAS
    RNA phosphodiester bond hydrolysis, exonucleolytic GO:0090503 TAS
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS
    gene expression GO:0010467 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    nucleus GO:0005634 IDA
    exosome (RNase complex) GO:0000178 TAS
    nucleolus GO:0005730 IEA
 Experiment description of studies that identified EXOSC7 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EXOSC7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DOM3Z  
Affinity Capture-MS Homo sapiens
2 EXOSC4 54512
Affinity Capture-MS Homo sapiens
3 EXOSC1 51013
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
4 IP6K1 9807
Two-hybrid Homo sapiens
5 EXOSC6 118460
Two-hybrid Homo sapiens
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