Gene description for SLIT2
Gene name slit homolog 2 (Drosophila)
Gene symbol SLIT2
Other names/aliases SLIL3
Slit-2
Species Homo sapiens
 Database cross references - SLIT2
ExoCarta ExoCarta_9353
Entrez Gene 9353
HGNC 11086
MIM 603746
UniProt O94813  
 SLIT2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SLIT2
Molecular Function
    proteoglycan binding GO:0043394 IPI
    identical protein binding GO:0042802 IPI
    chemorepellent activity GO:0045499 IEA
    protein homodimerization activity GO:0042803 IDA
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IDA
    laminin-1 binding GO:0043237 IDA
    calcium ion binding GO:0005509 NAS
    Roundabout binding GO:0048495 IPI
    GTPase inhibitor activity GO:0005095 IDA
Biological Process
    mammary duct terminal end bud growth GO:0060763 IEA
    negative regulation of endothelial cell migration GO:0010596 IDA
    induction of negative chemotaxis GO:0050929 IDA
    apoptotic process involved in luteolysis GO:0061364 IEP
    branching morphogenesis of an epithelial tube GO:0048754 IMP
    positive regulation of axonogenesis GO:0050772 TAS
    negative regulation of monocyte chemotaxis GO:0090027 ISS
    negative regulation of cell proliferation GO:0008285 IEA
    response to cortisol GO:0051414 IEP
    negative regulation of retinal ganglion cell axon guidance GO:0090260 IDA
    negative regulation of protein phosphorylation GO:0001933 IDA
    negative regulation of cell migration GO:0030336 IMP
    positive regulation of apoptotic process GO:0043065 IMP
    negative regulation of smooth muscle cell migration GO:0014912 IDA
    negative regulation of neutrophil chemotaxis GO:0090024 IDA
    dorsal/ventral axon guidance GO:0033563 IEA
    negative regulation of actin filament polymerization GO:0030837 IDA
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of small GTPase mediated signal transduction GO:0051058 IDA
    negative regulation of mononuclear cell migration GO:0071676 IDA
    corticospinal neuron axon guidance through spinal cord GO:0021972 IMP
    in utero embryonic development GO:0001701 IEA
    cellular response to heparin GO:0071504 IDA
    Roundabout signaling pathway GO:0035385 IMP
    negative regulation of chemokine-mediated signaling pathway GO:0070100 IMP
    negative regulation of vascular permeability GO:0043116 IDA
    motor neuron axon guidance GO:0008045 IDA
    retinal ganglion cell axon guidance GO:0031290 IDA
    single organismal cell-cell adhesion GO:0016337 IEA
    negative regulation of axon extension GO:0030517 IEA
    negative chemotaxis GO:0050919 IMP
    axon extension involved in axon guidance GO:0048846 IDA
    negative regulation of smooth muscle cell chemotaxis GO:0071672 IDA
    metanephros development GO:0001656 IEA
    chemorepulsion involved in postnatal olfactory bulb interneuron migration GO:0021836 IDA
    negative regulation of leukocyte chemotaxis GO:0002689 IDA
    ureteric bud development GO:0001657 IMP
    negative regulation of GTPase activity GO:0034260 IDA
    cell migration involved in sprouting angiogenesis GO:0002042 IMP
    negative regulation of lamellipodium assembly GO:0010593 IDA
    negative regulation of cell growth GO:0030308 IMP
    cellular response to hormone stimulus GO:0032870 IEP
    negative regulation of cellular response to growth factor stimulus GO:0090288 IDA
    axon guidance GO:0007411 TAS
    chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration GO:0021834 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    membrane GO:0016020 NAS
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IDA
    extracellular exosome GO:0070062 IDA
    cell surface GO:0009986 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLIT2 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SLIT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ROBO1  
Invivo Homo sapiens
2 ROBO2 6092
Invitro Homo sapiens
Invivo Homo sapiens
3 ROBO4  
Affinity Capture-Western Homo sapiens
4 GPC1 2817
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml



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