ExoCarta: Gene summary

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Gene description for PDGFRA
Gene name	platelet-derived growth factor receptor, alpha polypeptide
Gene symbol	PDGFRA
Other names/aliases	CD140A PDGFR-2 PDGFR2 RHEPDGFRA
Species	Homo sapiens
Database cross references - PDGFRA
ExoCarta	ExoCarta_5156
Vesiclepedia	VP_5156
Entrez Gene	5156
HGNC	8803
MIM	173490
UniProt	P16234
PDGFRA identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Chondrocytes	35931686
Chondrocytes	35931686
Mesenchymal stem cells	36408942

Gene ontology annotations for PDGFRA

Molecular Function
	protein kinase activity	GO:0004672	IDA
	transmembrane receptor protein tyrosine kinase activity	GO:0004714	IDA
	GPI-linked ephrin receptor activity	GO:0005004	IEA
	transmembrane-ephrin receptor activity	GO:0005005	IEA
	epidermal growth factor receptor activity	GO:0005006	IEA
	fibroblast growth factor receptor activity	GO:0005007	IEA
	hepatocyte growth factor receptor activity	GO:0005008	IEA
	insulin receptor activity	GO:0005009	IEA
	insulin-like growth factor receptor activity	GO:0005010	IEA
	macrophage colony-stimulating factor receptor activity	GO:0005011	IEA
	platelet-derived growth factor alpha-receptor activity	GO:0005018	IBA
	platelet-derived growth factor alpha-receptor activity	GO:0005018	IDA
	platelet-derived growth factor alpha-receptor activity	GO:0005018	IMP
	platelet-derived growth factor beta-receptor activity	GO:0005019	IEA
	stem cell factor receptor activity	GO:0005020	IEA
	vascular endothelial growth factor receptor activity	GO:0005021	IDA
	platelet-derived growth factor receptor binding	GO:0005161	IPI
	protein binding	GO:0005515	IPI
	ATP binding	GO:0005524	IEA
	boss receptor activity	GO:0008288	IEA
	histone H3Y41 kinase activity	GO:0035401	IEA
	placental growth factor receptor activity	GO:0036332	IEA
	protein tyrosine kinase collagen receptor activity	GO:0038062	IEA
	vascular endothelial growth factor binding	GO:0038085	IPI
	protein homodimerization activity	GO:0042803	IDA
	protein-containing complex binding	GO:0044877	IEA
	platelet-derived growth factor binding	GO:0048407	IBA
	platelet-derived growth factor binding	GO:0048407	IDA
	platelet-derived growth factor binding	GO:0048407	IPI
	brain-derived neurotrophic factor receptor activity	GO:0060175	IEA
	histone H2AXY142 kinase activity	GO:0140801	IEA
	phospholipase C activator activity	GO:0160185	IMP
Biological Process
	luteinization	GO:0001553	ISS
	in utero embryonic development	GO:0001701	IEA
	cell activation	GO:0001775	TAS
	hematopoietic progenitor cell differentiation	GO:0002244	IEA
	chromatin remodeling	GO:0006338	IEA
	cell surface receptor protein tyrosine kinase signaling pathway	GO:0007169	IBA
	epidermal growth factor receptor signaling pathway	GO:0007173	IEA
	multicellular organism development	GO:0007275	IBA
	estrogen metabolic process	GO:0008210	IEA
	positive regulation of cell population proliferation	GO:0008284	IDA
	positive regulation of cell population proliferation	GO:0008284	IMP
	insulin receptor signaling pathway	GO:0008286	IEA
	fibroblast growth factor receptor signaling pathway	GO:0008543	IEA
	negative regulation of platelet activation	GO:0010544	IDA
	peptidyl-tyrosine phosphorylation	GO:0018108	IDA
	signal transduction involved in regulation of gene expression	GO:0023019	IEA
	extracellular matrix organization	GO:0030198	IEA
	lung development	GO:0030324	IEA
	adrenal gland development	GO:0030325	IEA
	positive regulation of cell migration	GO:0030335	IDA
	positive regulation of cell migration	GO:0030335	IMP
	male genitalia development	GO:0030539	IEA
	brain-derived neurotrophic factor receptor signaling pathway	GO:0031547	IEA
	regulation of actin cytoskeleton organization	GO:0032956	TAS
	Leydig cell differentiation	GO:0033327	IEA
	cellular response to reactive oxygen species	GO:0034614	IDA
	platelet-derived growth factor receptor-alpha signaling pathway	GO:0035790	IMP
	platelet-derived growth factor receptor-beta signaling pathway	GO:0035791	IEA
	vascular endothelial growth factor receptor-1 signaling pathway	GO:0036323	IEA
	collagen-activated tyrosine kinase receptor signaling pathway	GO:0038063	IEA
	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:0038091	IDA
	Kit signaling pathway	GO:0038109	IEA
	macrophage colony-stimulating factor signaling pathway	GO:0038145	IEA
	wound healing	GO:0042060	ISS
	odontogenesis of dentin-containing tooth	GO:0042475	IEA
	protein autophosphorylation	GO:0046777	IDA
	platelet-derived growth factor receptor signaling pathway	GO:0048008	IDA
	insulin-like growth factor receptor signaling pathway	GO:0048009	IEA
	hepatocyte growth factor receptor signaling pathway	GO:0048012	IEA
	ephrin receptor signaling pathway	GO:0048013	IEA
	positive regulation of fibroblast proliferation	GO:0048146	IDA
	embryonic digestive tract morphogenesis	GO:0048557	ISS
	embryonic cranial skeleton morphogenesis	GO:0048701	IBA
	embryonic cranial skeleton morphogenesis	GO:0048701	ISS
	embryonic skeletal system morphogenesis	GO:0048704	ISS
	positive regulation of calcium-mediated signaling	GO:0050850	IMP
	white fat cell differentiation	GO:0050872	IEA
	positive regulation of chemotaxis	GO:0050921	IMP
	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	GO:0051897	TAS
	cardiac myofibril assembly	GO:0055003	ISS
	roof of mouth development	GO:0060021	IEA
	face morphogenesis	GO:0060325	IEA
	cell chemotaxis	GO:0060326	IEA
	retina vasculature development in camera-type eye	GO:0061298	ISS
	positive regulation of ERK1 and ERK2 cascade	GO:0070374	IMP
	platelet aggregation	GO:0070527	IMP
	cellular response to amino acid stimulus	GO:0071230	IEA
	metanephric glomerular capillary formation	GO:0072277	ISS
	regulation of mesenchymal stem cell differentiation	GO:2000739	IMP
Subcellular Localization
	nucleus	GO:0005634	ISS
	nucleoplasm	GO:0005654	IDA
	cytoplasm	GO:0005737	ISS
	endoplasmic reticulum membrane	GO:0005789	TAS
	Golgi apparatus	GO:0005794	ISS
	plasma membrane	GO:0005886	IBA
	plasma membrane	GO:0005886	IDA
	plasma membrane	GO:0005886	TAS
	microvillus	GO:0005902	IEA
	cilium	GO:0005929	ISS
	external side of plasma membrane	GO:0009897	IEA
	membrane	GO:0016020	HDA
	cell junction	GO:0030054	IDA
	protein-containing complex	GO:0032991	IDA
	receptor complex	GO:0043235	IBA

Experiment description of studies that identified PDGFRA in sEVs

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

494

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD81\|CD151\|CD63\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|SDCBP\|TFRC\|TSG101	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

"Varela-EirÃn M, Carpintero-FernÃ¡ndez P, GuitiÃ¡n-CaamaÃ±o A, Varela-VÃ¡zquez A, GarcÃa-Yuste A, SÃ¡nchez-Temprano A, Bravo-LÃ³pez SB, YaÃ±ez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, MayÃ¡n MD."

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

Osteoarthritic cartilage

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

496

MISEV standards
✘	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|SDCBP\|TFRC\|TSG101	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

Healthy cartilage

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

488

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD81\|CD63\|GAPDH\|SDCBP\|LAMP1\|TFRC\|UCHL1\|FLOT2\|LAMP2\|FLOT1\|ICAM1\|RAB5B\|CD151\|RAB35\|TSG101\|RAB5A\|CD82	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Homo sapiens

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Mesenchymal stem cells

Sample name

UCMSC

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Protein-protein interactions for PDGFRA

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

DCBLD2

131566

Affinity Capture-MS

Homo sapiens

TIMP3

7078

Affinity Capture-MS

Homo sapiens

NOMO1

23420

Affinity Capture-MS

Homo sapiens

UGGT2

55757

Affinity Capture-MS

Homo sapiens

SLIT2

9353

Affinity Capture-MS

Homo sapiens

DECR2

26063

Affinity Capture-MS

Homo sapiens

CNTNAP3

Affinity Capture-MS

Homo sapiens

SCNN1A

Affinity Capture-MS

Homo sapiens

CNTNAP3B

Affinity Capture-MS

Homo sapiens

CACNA2D2

9254

Affinity Capture-MS

Homo sapiens

EXTL2

2135

Affinity Capture-MS

Homo sapiens

Pik3r1

Affinity Capture-Western

Mus musculus

MAN2A1

4124

Affinity Capture-MS

Homo sapiens

GCNT1

Affinity Capture-MS

Homo sapiens

CRK

1398

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Co-localization		Homo sapiens
Affinity Capture-Western		Homo sapiens

FBXO25

Biochemical Activity

Homo sapiens

CYB5R1

51706

Affinity Capture-MS

Homo sapiens

BRCA1

672

Negative Genetic

Homo sapiens

ARSB

411

Affinity Capture-MS

Homo sapiens

ST8SIA4

7903

Affinity Capture-MS

Homo sapiens

XYLT2

64132

Affinity Capture-MS

Homo sapiens

ITGA4

3676

Affinity Capture-MS

Homo sapiens

VHL

Negative Genetic

Homo sapiens

SHF

90525

Reconstituted Complex

Homo sapiens

GPR110

Affinity Capture-MS

Homo sapiens

GLCE

26035

Affinity Capture-MS

Homo sapiens

HS6ST2

90161

Affinity Capture-MS

Homo sapiens

SNX6

58533

Affinity Capture-Western

Homo sapiens

LRRC24

Affinity Capture-MS

Homo sapiens

ERO1LB

56605

Affinity Capture-MS

Homo sapiens

POMGNT2

Affinity Capture-MS

Homo sapiens

FGFR3

2261

Affinity Capture-MS

Homo sapiens

WNT11

7481

Affinity Capture-MS

Homo sapiens

CHST10

Affinity Capture-MS

Homo sapiens

MGAT5

4249

Affinity Capture-MS

Homo sapiens

QSOX2

169714

Affinity Capture-MS

Homo sapiens

GXYLT1

283464

Affinity Capture-MS

Homo sapiens

B4GALT4

8702

Affinity Capture-MS

Homo sapiens

RNPS1

10921

Affinity Capture-MS

Homo sapiens

TNK1

Affinity Capture-MS

Homo sapiens

SULF2

55959

Affinity Capture-MS

Homo sapiens

PLAU

5328

Affinity Capture-MS

Homo sapiens

TGFB1

7040

Affinity Capture-MS

Homo sapiens

Nedd4

25489

Biochemical Activity

Rattus norvegicus

PXDN

7837

Affinity Capture-MS

Homo sapiens

PDIA5

10954

Affinity Capture-MS

Homo sapiens

ADAM9

8754

Affinity Capture-MS

Homo sapiens

WDR74

54663

Affinity Capture-MS

Homo sapiens

PACS1

55690

Affinity Capture-MS

Homo sapiens

HYAL2

8692

Affinity Capture-MS

Homo sapiens

CRELD2

79174

Affinity Capture-MS

Homo sapiens

STAT3

6774

Co-localization

Homo sapiens

OAF

220323

Affinity Capture-MS

Homo sapiens

MAN1A1

4121

Affinity Capture-MS

Homo sapiens

SEMA6B

10501

Affinity Capture-MS

Homo sapiens

PHLDB2

90102

Affinity Capture-MS

Homo sapiens

PLCG1

5335

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-localization		Homo sapiens

SERPINF1

5176

Affinity Capture-MS

Homo sapiens

NLGN2

57555

Affinity Capture-MS

Homo sapiens

ITGA8

8516

Affinity Capture-MS

Homo sapiens

SEMA4G

Affinity Capture-MS

Homo sapiens

ICAM4

Affinity Capture-MS

Homo sapiens

SMPD1

6609

Affinity Capture-MS

Homo sapiens

ENTPD5

957

Affinity Capture-MS

Homo sapiens

EOGT

285203

Affinity Capture-MS

Homo sapiens

CHST3

9469

Affinity Capture-MS

Homo sapiens

GXYLT2

Affinity Capture-MS

Homo sapiens

IL17RA

23765

Affinity Capture-MS

Homo sapiens

SULF1

23213

Affinity Capture-MS

Homo sapiens

CBR4

Affinity Capture-MS

Homo sapiens

ERBB2

2064

PCA

Homo sapiens

MAK16

Affinity Capture-MS

Homo sapiens

PCYOX1

51449

Affinity Capture-MS

Homo sapiens

TFRC

7037

Affinity Capture-MS

Homo sapiens

SNX4

8723

Affinity Capture-Western

Homo sapiens

EHD1

10938

Affinity Capture-MS

Homo sapiens

GDF15

9518

Affinity Capture-MS

Homo sapiens

HSPA13

6782

Affinity Capture-MS

Homo sapiens

CTSV

1515

Affinity Capture-MS

Homo sapiens

MELK

Affinity Capture-MS

Homo sapiens

CHST12

55501

Affinity Capture-MS

Homo sapiens

CES3

23491

Affinity Capture-MS

Homo sapiens

CHID1

66005

Affinity Capture-MS

Homo sapiens

B3GALTL

145173

Affinity Capture-MS

Homo sapiens

CAV3

859

Reconstituted Complex

Homo sapiens

TAZ

Affinity Capture-MS

Homo sapiens

CA11

Affinity Capture-MS

Homo sapiens

IDUA

3425

Affinity Capture-MS

Homo sapiens

PAM

5066

Affinity Capture-MS

Homo sapiens

ITGB3

3690

Affinity Capture-Western

Homo sapiens

KIT

3815

Affinity Capture-Western

Homo sapiens

SCFD1

23256

Affinity Capture-MS

Homo sapiens

TOR1B

27348

Affinity Capture-MS

Homo sapiens

FUT8

2530

Affinity Capture-MS

Homo sapiens

NTN1

9423

Affinity Capture-MS

Homo sapiens

CLU

1191

Affinity Capture-MS

Homo sapiens

PRSS12

8492

Affinity Capture-MS

Homo sapiens

UGT8

Affinity Capture-MS

Homo sapiens

HS6ST1

Affinity Capture-MS

Homo sapiens

100

GALNT12

79695

Affinity Capture-MS

Homo sapiens

101

CBL

867

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

102

CHPF2

54480

Affinity Capture-MS

Homo sapiens

103

B4GALT6

Affinity Capture-MS

Homo sapiens

104

PPIL2

Affinity Capture-MS

Homo sapiens

105

EMILIN3

Affinity Capture-MS

Homo sapiens

106

KDELC2

143888

Affinity Capture-MS

Homo sapiens

107

SREBF2

6721

Positive Genetic

Homo sapiens

108

MAN2A2

4122

Affinity Capture-MS

Homo sapiens

109

B3GNT2

10678

Affinity Capture-MS

Homo sapiens

110

NTRK1

4914

Affinity Capture-MS

Homo sapiens

111

CRKL

1399

Co-localization		Homo sapiens
Affinity Capture-Western		Homo sapiens

112

MGAT1

4245

Affinity Capture-MS

Homo sapiens

113

NEK4

Affinity Capture-MS

Homo sapiens

114

ITGA7

3679

Affinity Capture-MS

Homo sapiens

115

H6PD

9563

Affinity Capture-MS

Homo sapiens

116

WNT5A

7474

Affinity Capture-MS

Homo sapiens

117

BMP7

655

Affinity Capture-MS

Homo sapiens

118

RDH11

51109

Affinity Capture-MS

Homo sapiens

119

DHFRL1

Affinity Capture-MS

Homo sapiens

120

TPST1

8460

Affinity Capture-MS

Homo sapiens

121

PIK3R1

5295

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-localization		Homo sapiens

122

B4GALT3

8703

Affinity Capture-MS

Homo sapiens

123

ART5

Affinity Capture-MS

Homo sapiens

124

GALNS

2588

Affinity Capture-MS

Homo sapiens

125

DNM2

1785

Affinity Capture-Western

Homo sapiens

126

TRMT2A

27037

Affinity Capture-MS

Homo sapiens

127

PDGFC

56034

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

128

AHCTF1

25909

Affinity Capture-MS

Homo sapiens

129

ICAM5

7087

Affinity Capture-MS

Homo sapiens

130

MGAT2

4247

Affinity Capture-MS

Homo sapiens

131

FGFR4

2264

Affinity Capture-MS

Homo sapiens

132

GALNT5

11227

Affinity Capture-MS

Homo sapiens

133

SRPK1

6732

Biochemical Activity

Homo sapiens

134

CERCAM

51148

Affinity Capture-MS

Homo sapiens

135

TXNDC11

51061

Affinity Capture-MS

Homo sapiens

136

EPHB4

2050

Affinity Capture-MS

Homo sapiens

137

BRINP3

Affinity Capture-MS

Homo sapiens

138

SQRDL

58472

Affinity Capture-MS

Homo sapiens

139

ULBP3

79465

Affinity Capture-MS

Homo sapiens

140

C1GALT1C1

29071

Affinity Capture-MS

Homo sapiens

141

GLB1L

79411

Affinity Capture-MS

Homo sapiens

142

MBTPS1

8720

Affinity Capture-MS

Homo sapiens

143

BCAM

4059

Affinity Capture-MS

Homo sapiens

144

PTPN11

5781

Affinity Capture-Western

Homo sapiens

145

PLAT

5327

Affinity Capture-MS

Homo sapiens

146

QSOX1

5768

Affinity Capture-MS

Homo sapiens

147

NDST2

Affinity Capture-MS

Homo sapiens

148

ADGRG1

9289

Affinity Capture-MS

Homo sapiens

149

BMP8B

Affinity Capture-MS

Homo sapiens

150

GUSB

2990

Affinity Capture-MS

Homo sapiens

151

GALNT6

11226

Affinity Capture-MS

Homo sapiens

152

GGH

8836

Affinity Capture-MS

Homo sapiens

153

BMP1

649

Affinity Capture-MS

Homo sapiens

154

B4GALNT3

Affinity Capture-MS

Homo sapiens

155

B3GNT3

10331

Affinity Capture-MS

Homo sapiens

156

PDGFRA

5156

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Far Western		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Far Western		Homo sapiens
Biochemical Activity		Homo sapiens
Biochemical Activity		Homo sapiens

157

GRID1

2894

Affinity Capture-MS

Homo sapiens

158

SEMA3D

Affinity Capture-MS

Homo sapiens

159

LPCAT4

Affinity Capture-MS

Homo sapiens

160

LOXL2

4017

Affinity Capture-MS

Homo sapiens

161

PTEN

5728

Affinity Capture-MS

Homo sapiens

162

CD9

928

Co-localization

Homo sapiens

163

EGFR

1956

Two-hybrid		Homo sapiens
PCA		Homo sapiens
Affinity Capture-Luminescence		Homo sapiens

164

DNAJB9

4189

Affinity Capture-MS

Homo sapiens

165

THOC5

8563

Affinity Capture-MS

Homo sapiens

166

CCDC155

Two-hybrid

Homo sapiens

167

PACSIN3

29763

Affinity Capture-MS

Homo sapiens

168

PDGFRB

5159

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens

169

PCSK9

255738

Affinity Capture-MS

Homo sapiens

170

LAMB3

3914

Affinity Capture-MS

Homo sapiens

171

ECE1

1889

Affinity Capture-MS

Homo sapiens

172

MYO1C

4641

Affinity Capture-MS

Homo sapiens

173

GYLTL1B

120071

Affinity Capture-MS

Homo sapiens

174

SETX

Affinity Capture-MS

Homo sapiens

175

RRM2

6241

Negative Genetic

Homo sapiens

176

PLTP

5360

Affinity Capture-MS

Homo sapiens

177

LAMA1

284217

Affinity Capture-MS

Homo sapiens

178

EXT1

2131

Affinity Capture-MS

Homo sapiens

179

STAT1

6772

Co-localization

Homo sapiens

180

PDGFRL

5157

Affinity Capture-MS

Homo sapiens

181

NRD1

4898

Affinity Capture-MS

Homo sapiens

182

LRIG1

26018

Affinity Capture-MS

Homo sapiens

183

PCOLCE2

26577

Affinity Capture-MS

Homo sapiens

184

CHRD

Affinity Capture-MS

Homo sapiens

185

MTOR

2475

Negative Genetic

Homo sapiens

186

TXNDC16

57544

Affinity Capture-MS

Homo sapiens

187

TOP1

7150

Negative Genetic

Homo sapiens

188

POTEKP

440915

Affinity Capture-MS

Homo sapiens

189

GALNT7

51809

Affinity Capture-MS

Homo sapiens

190

HPSE

10855

Affinity Capture-MS

Homo sapiens

191

P3H3

10536

Affinity Capture-MS

Homo sapiens

192

TMEM2

23670

Affinity Capture-MS

Homo sapiens

193

ENTPD2

954

Affinity Capture-MS

Homo sapiens

194

CTSF

8722

Affinity Capture-MS

Homo sapiens

195

GALNT2

2590

Affinity Capture-MS

Homo sapiens

196

STC2

8614

Affinity Capture-MS

Homo sapiens

197

PPAPDC2

Two-hybrid

Homo sapiens

198

POGLUT1

56983

Affinity Capture-MS

Homo sapiens

199

CD55

1604

Affinity Capture-MS

Homo sapiens

200

ST3GAL6

10402

Affinity Capture-MS

Homo sapiens

201

RHEB

6009

Affinity Capture-MS

Homo sapiens

202

FAM213A

84293

Affinity Capture-MS

Homo sapiens

203

CBWD1

55871

Affinity Capture-MS

Homo sapiens

204

ENPP1

5167

Affinity Capture-MS

Homo sapiens

205

FLOT1

10211

Affinity Capture-MS

Homo sapiens

206

FARP1

10160

Affinity Capture-MS

Homo sapiens

207

NDNF

Affinity Capture-MS

Homo sapiens

208

ADAMTS15

170689

Affinity Capture-MS

Homo sapiens

209

NDST1

3340

Affinity Capture-MS

Homo sapiens

210

PDGFA

5154

Co-localization		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens

211

ADAMTS1

9510

Affinity Capture-MS

Homo sapiens

212

GALNT10

55568

Affinity Capture-MS

Homo sapiens

213

LAMB1

3912

Affinity Capture-MS

Homo sapiens

214

INHBE

83729

Affinity Capture-MS

Homo sapiens

215

HS3ST1

Affinity Capture-MS

Homo sapiens

216

FASN

2194

Positive Genetic

Homo sapiens

217

TTC17

55761

Affinity Capture-MS

Homo sapiens

218

BCHE

590

Affinity Capture-MS

Homo sapiens

219

PDGFB

Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens

220

GRB2

2885

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

221

H3F3A

3020

Affinity Capture-MS

Homo sapiens

222

ENTPD6

Affinity Capture-MS

Homo sapiens

223

GTPBP6

Affinity Capture-MS

Homo sapiens

224

WNT10B

7480

Affinity Capture-MS

Homo sapiens

225

ULBP2

80328

Two-hybrid

Homo sapiens

226

SEMA3C

10512

Affinity Capture-MS

Homo sapiens

227

PLXNA1

5361

Affinity Capture-MS

Homo sapiens

228

CHST14

113189

Affinity Capture-MS

Homo sapiens

229

TMEM131

Affinity Capture-MS

Homo sapiens

230

SMURF1

57154

Biochemical Activity

Homo sapiens

231

EFNB1

1947

Affinity Capture-MS

Homo sapiens

232

FAM132B

Affinity Capture-MS

Homo sapiens

233

RPL23

9349

Affinity Capture-MS

Homo sapiens

234

PRSS23

11098

Affinity Capture-MS

Homo sapiens

235

PRKRIP1

79706

Affinity Capture-MS

Homo sapiens

236

COL18A1

80781

Affinity Capture-MS

Homo sapiens

237

LARGE

9215

Affinity Capture-MS

Homo sapiens

238

BDNF

627

Affinity Capture-MS

Homo sapiens

239

PDIA4

9601

Affinity Capture-MS

Homo sapiens

240

COCH

1690

Affinity Capture-MS

Homo sapiens

241

RAB11FIP1

80223

Affinity Capture-MS

Homo sapiens

242

KDELC1

79070

Affinity Capture-MS

Homo sapiens

243

AGRN

375790

Affinity Capture-MS

Homo sapiens

244

SEMA3B

7869

Affinity Capture-MS

Homo sapiens

245

P3H4

10609

Affinity Capture-MS

Homo sapiens

246

ST3GAL4

6484

Affinity Capture-MS

Homo sapiens

247

LPCAT2

54947

Affinity Capture-MS

Homo sapiens

248

GALNT18

Affinity Capture-MS

Homo sapiens

249

MINPP1

9562

Affinity Capture-MS

Homo sapiens

250

ARSG

22901

Affinity Capture-MS

Homo sapiens

251

EXTL3

2137

Affinity Capture-MS

Homo sapiens

252

NXPE3

Affinity Capture-MS

Homo sapiens

253

SERPINE2

5270

Affinity Capture-MS

Homo sapiens

254

SPPL2B

56928

Affinity Capture-MS

Homo sapiens

255

SEMA3F

6405

Affinity Capture-MS

Homo sapiens

256

CDK9

1025

Negative Genetic

Homo sapiens

257

LAMB2

3913

Affinity Capture-MS

Homo sapiens

258

SLC9A3R1

9368

Far Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Far Western		Homo sapiens
Reconstituted Complex		Homo sapiens

259

PXYLP1

Affinity Capture-MS

Homo sapiens

260

BMP8A

Affinity Capture-MS

Homo sapiens

261

LAMA5

3911

Affinity Capture-MS

Homo sapiens

262

ACSF3

197322

Affinity Capture-MS

Homo sapiens

263

SNX2

6643

Affinity Capture-Western

Homo sapiens

264

LRP11

Affinity Capture-MS

Homo sapiens

265

TGFBR2

7048

Two-hybrid

Homo sapiens

266

TMEM132A

54972

Affinity Capture-MS

Homo sapiens

267

CHSY1

22856

Affinity Capture-MS

Homo sapiens

268

ARSK

Affinity Capture-MS

Homo sapiens

269

CHSY3

337876

Affinity Capture-MS

Homo sapiens

270

CAV1

857

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Reconstituted Complex		Homo sapiens

271

WNT16

Affinity Capture-MS

Homo sapiens

272

SEMA4B

Affinity Capture-MS

Homo sapiens

273

MFGE8

4240

Affinity Capture-MS

Homo sapiens

274

CRLF1

9244

Affinity Capture-MS

Homo sapiens

275

OLFM2

Affinity Capture-MS

Homo sapiens

276

DSG2

1829

Affinity Capture-MS

Homo sapiens

277

PDF

Affinity Capture-MS

Homo sapiens

View the network

Pathways in which PDGFRA is involved

Pathway	Evidence	Source
Constitutive Signaling by Aberrant PI3K in Cancer	TAS	Reactome
Disease	TAS	Reactome
Diseases of signal transduction by growth factor receptors and second messengers	TAS	Reactome
Downstream signal transduction	TAS	Reactome
Drug resistance of PDGFR mutants	TAS	Reactome
Imatinib-resistant PDGFR mutants	TAS	Reactome
Intracellular signaling by second messengers	TAS	Reactome
MAPK family signaling cascades	TAS	Reactome
MAPK1/MAPK3 signaling	TAS	Reactome
Negative regulation of the PI3K/AKT network	TAS	Reactome
PDGFR mutants bind TKIs	TAS	Reactome
PI3K/AKT Signaling in Cancer	TAS	Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS	Reactome
PIP3 activates AKT signaling	TAS	Reactome
RAF/MAP kinase cascade	TAS	Reactome
Regorafenib-resistant PDGFR mutants	TAS	Reactome
Signal Transduction	TAS	Reactome
Signaling by PDGF	TAS	Reactome
Signaling by PDGFR in disease	TAS	Reactome
Signaling by PDGFRA extracellular domain mutants	TAS	Reactome
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants	TAS	Reactome
Signaling by Receptor Tyrosine Kinases	TAS	Reactome
Sorafenib-resistant PDGFR mutants	TAS	Reactome
Sunitinib-resistant PDGFR mutants	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here