Gene description for PDGFRA
Gene name platelet-derived growth factor receptor, alpha polypeptide
Gene symbol PDGFRA
Other names/aliases CD140A
PDGFR-2
PDGFR2
RHEPDGFRA
Species Homo sapiens
 Database cross references - PDGFRA
ExoCarta ExoCarta_5156
Vesiclepedia VP_5156
Entrez Gene 5156
HGNC 8803
MIM 173490
UniProt P16234  
 PDGFRA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PDGFRA
Molecular Function
    vascular endothelial growth factor-activated receptor activity GO:0005021 IDA
    platelet-derived growth factor receptor binding GO:0005161 IPI
    vascular endothelial growth factor binding GO:0038085 IPI
    ATP binding GO:0005524 IEA
    protein kinase activity GO:0004672 IDA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA
    protein binding GO:0005515 IPI
    platelet-derived growth factor binding GO:0048407 IPI
    platelet-derived growth factor alpha-receptor activity GO:0005018 IMP
    protein homodimerization activity GO:0042803 IDA
Biological Process
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    luteinization GO:0001553 ISS
    protein autophosphorylation GO:0046777 IDA
    retina vasculature development in camera-type eye GO:0061298 ISS
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    estrogen metabolic process GO:0008210 IEA
    regulation of mesenchymal stem cell differentiation GO:2000739 IMP
    regulation of actin cytoskeleton reorganization GO:2000249 TAS
    cell chemotaxis GO:0060326 IMP
    positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IMP
    positive regulation of phospholipase C activity GO:0010863 IMP
    positive regulation of cell proliferation GO:0008284 IMP
    extracellular matrix organization GO:0030198 IEA
    cardiac myofibril assembly GO:0055003 ISS
    viral process GO:0016032 IEA
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    positive regulation of cell migration GO:0030335 IMP
    face morphogenesis GO:0060325 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IMP
    wound healing GO:0042060 ISS
    embryonic digestive tract morphogenesis GO:0048557 ISS
    embryonic cranial skeleton morphogenesis GO:0048701 ISS
    platelet-derived growth factor receptor signaling pathway GO:0048008 IDA
    innate immune response GO:0045087 TAS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    cell activation GO:0001775 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    Leydig cell differentiation GO:0033327 IEA
    in utero embryonic development GO:0001701 IEA
    platelet aggregation GO:0070527 IMP
    cellular response to reactive oxygen species GO:0034614 IDA
    positive regulation of DNA replication GO:0045740 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    palate development GO:0060021 IEA
    positive regulation of fibroblast proliferation GO:0048146 IDA
    adrenal gland development GO:0030325 IEA
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IMP
    cellular response to amino acid stimulus GO:0071230 IEA
    male genitalia development GO:0030539 IEA
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    negative regulation of platelet activation GO:0010544 IDA
    regulation of chemotaxis GO:0050920 IMP
    positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 IDA
    signal transduction involved in regulation of gene expression GO:0023019 IEA
    embryonic skeletal system morphogenesis GO:0048704 ISS
    odontogenesis of dentin-containing tooth GO:0042475 IEA
    lung development GO:0030324 IEA
    metanephric glomerular capillary formation GO:0072277 ISS
Subcellular Localization
    nucleus GO:0005634 ISS
    protein complex GO:0043234 IDA
    plasma membrane GO:0005886 TAS
    cytoplasm GO:0005737 ISS
    integral component of plasma membrane GO:0005887 IDA
    microvillus GO:0005902 IEA
    external side of plasma membrane GO:0009897 IEA
    intrinsic component of plasma membrane GO:0031226 IDA
    cytosol GO:0005829 IMP
    membrane GO:0016020 IDA
 Experiment description of studies that identified PDGFRA in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
EV Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
EV Enriched markers
✔
Canx
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PDGFRA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDGFA 5154
Reconstituted Complex Homo sapiens
2 CBL 867
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 CRK 1398
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 ITGB3 3690
Invivo Homo sapiens
Invitro Homo sapiens
5 SNX2 6643
Invivo Homo sapiens
Invitro Homo sapiens
6 ITGAV 3685
Invivo Homo sapiens
Invitro Homo sapiens
7 PDGFRA 5156
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
8 GRB2 2885
Affinity Capture-Western Homo sapiens
9 PTPN11 5781
Affinity Capture-MS Homo sapiens
10 PLCG1 5335
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 PDGFC 56034
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 PDGFB  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
13 CAV1 857
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
14 SNX4 8723
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
15 CRKL 1399
Affinity Capture-Western Homo sapiens
16 PDGFRB 5159
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 SLC9A3R1 9368
Invitro Homo sapiens
18 SNX6 58533
Invivo Homo sapiens
Invitro Homo sapiens
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