Gene description for SNX6
Gene name sorting nexin 6
Gene symbol SNX6
Other names/aliases MSTP010
TFAF2
Species Homo sapiens
 Database cross references - SNX6
ExoCarta ExoCarta_58533
Entrez Gene 58533
HGNC 14970
MIM 606098
UniProt Q9UNH7  
 SNX6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for SNX6
Molecular Function
    dynactin binding GO:0034452 IDA
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 IBA
    protein homodimerization activity GO:0042803 IPI
Biological Process
    endocytosis GO:0006897 IBA
    regulation of histamine secretion by mast cell GO:1903593 IMP
    vesicle organization GO:0016050 IBA
    retrograde transport, endosome to Golgi GO:0042147 IMP
    negative regulation of epidermal growth factor-activated receptor activity GO:0007175 NAS
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA
    intracellular protein transport GO:0006886 NAS
Subcellular Localization
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    extrinsic component of membrane GO:0019898 IBA
    nucleus GO:0005634 IEA
    tubular endosome GO:0097422 IDA
    retromer complex GO:0030904 IDA
    endosome GO:0005768 IBA
    intracellular GO:0005622 NAS
    cytoplasm GO:0005737 IDA
    early endosome membrane GO:0031901 IDA
 Experiment description of studies that identified SNX6 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SNX6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACVRL1  
Invivo Homo sapiens
Invitro Homo sapiens
2 SNX1 6642
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
3 SNX2 6643
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
4 LEPR 3953
Invivo Homo sapiens
Invitro Homo sapiens
5 ACVR2B  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
6 PDGFRA  
Invivo Homo sapiens
Invitro Homo sapiens
7 SMAD1  
Two-hybrid Homo sapiens
8 PIM1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
9 INSR 3643
Invivo Homo sapiens
Invitro Homo sapiens
10 EGFR 1956
Invivo Homo sapiens
Invitro Homo sapiens
11 TGFBR2 7048
Invivo Homo sapiens
Invitro Homo sapiens
12 SNX4 8723
Invivo Homo sapiens
Invitro Homo sapiens
13 BMPR1B  
Invivo Homo sapiens
Invitro Homo sapiens
14 TGFBR1  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which SNX6 is involved
No pathways found





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