Gene description for PDE4DIP
Gene name phosphodiesterase 4D interacting protein
Gene symbol PDE4DIP
Other names/aliases CMYA2
MMGL
Species Homo sapiens
 Database cross references - PDE4DIP
ExoCarta ExoCarta_9659
Vesiclepedia VP_9659
Entrez Gene 9659
HGNC 15580
MIM 608117
UniProt Q5VU43  
 PDE4DIP identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for PDE4DIP
Molecular Function
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 ISS
    molecular adaptor activity GO:0060090 IBA
    molecular adaptor activity GO:0060090 IDA
Biological Process
    centrosome cycle GO:0007098 IBA
    astral microtubule organization GO:0030953 IMP
    protein-containing complex assembly GO:0065003 ISS
    positive regulation of microtubule nucleation GO:0090063 IMP
    regulation of Golgi organization GO:1903358 IBA
    regulation of Golgi organization GO:1903358 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    Golgi apparatus GO:0005794 ISS
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    centrosome GO:0005813 ISS
    myofibril GO:0030016 ISS
    cortical microtubule plus-end GO:1903754 IDA
 Experiment description of studies that identified PDE4DIP in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PDE4DIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZBTB38 253461
Two-hybrid Homo sapiens
2 AKR1B10 57016
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 C14orf105  
Two-hybrid Homo sapiens
4 OR10H1  
Affinity Capture-MS Homo sapiens
5 SERPINB4 6318
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 CLIP1 6249
Affinity Capture-MS Homo sapiens
7 TK1 7083
Two-hybrid Homo sapiens
8 TRAF4 9618
Two-hybrid Homo sapiens
9 FAM74A4  
Two-hybrid Homo sapiens
10 GADD45G  
Two-hybrid Homo sapiens
11 CEP170 9859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ANXA8 653145
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PRKACG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 BYSL 705
Two-hybrid Homo sapiens
15 EFCAB1  
Affinity Capture-MS Homo sapiens
16 PPL 5493
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CALM1 801
Affinity Capture-MS Homo sapiens
18 SNX6 58533
Affinity Capture-MS Homo sapiens
19 ZNF414  
Two-hybrid Homo sapiens
20 RTP5  
Two-hybrid Homo sapiens
21 ATXN7L1 222255
Affinity Capture-MS Homo sapiens
22 C1orf87  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ZNF408  
Two-hybrid Homo sapiens
24 USO1 8615
Affinity Capture-MS Homo sapiens
25 NDRG1 10397
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 C3 718
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 NAA11 84779
Affinity Capture-MS Homo sapiens
28 LENG1  
Two-hybrid Homo sapiens
29 FES 2242
Two-hybrid Homo sapiens
30 PPP1R18 170954
Two-hybrid Homo sapiens
31 PIAS4  
Two-hybrid Homo sapiens
32 COQ3  
Affinity Capture-MS Homo sapiens
33 TNIK 23043
Two-hybrid Homo sapiens
34 ZNF512B  
Two-hybrid Homo sapiens
35 TFIP11  
Two-hybrid Homo sapiens
36 GOLGA8EP  
Two-hybrid Homo sapiens
37 MTUS2 23281
Two-hybrid Homo sapiens
38 CCDC6 8030
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 KRT31 3881
Two-hybrid Homo sapiens
40 LAMTOR3 8649
Two-hybrid Homo sapiens
41 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 TULP3 7289
Affinity Capture-MS Homo sapiens
43 KLC4 89953
Two-hybrid Homo sapiens
44 CSNK1D 1453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 SDCBP 6386
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 ARNT2  
Two-hybrid Homo sapiens
47 LMO4  
Two-hybrid Homo sapiens
48 GFI1B  
Two-hybrid Homo sapiens
49 KIF14 9928
Affinity Capture-MS Homo sapiens
50 PRNP 5621
Reconstituted Complex Homo sapiens
51 HMGCS2 3158
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 AEN  
Two-hybrid Homo sapiens
53 ALDH1A3 220
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PM20D1 148811
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 POF1B 79983
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 Asap1  
Two-hybrid Mus musculus
57 ZNF124  
Two-hybrid Homo sapiens
58 GOLGA8F  
Two-hybrid Homo sapiens
59 CDKN1A  
Two-hybrid Homo sapiens
60 CST6  
Affinity Capture-MS Homo sapiens
61 FAM50B  
Two-hybrid Homo sapiens
62 CHCHD3 54927
Two-hybrid Homo sapiens
63 FAM9C  
Affinity Capture-MS Homo sapiens
64 SCNM1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
65 MAPRE1 22919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
66 GDPD3 79153
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 FYN 2534
Affinity Capture-Western Homo sapiens
68 KLC3  
Two-hybrid Homo sapiens
69 SWAP70 23075
Affinity Capture-MS Homo sapiens
70 IGHG1 3500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 TRIM21 6737
Affinity Capture-MS Homo sapiens
72 ENTPD1 953
Affinity Capture-MS Homo sapiens
73 NAA10 8260
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
74 ZSCAN26  
Two-hybrid Homo sapiens
75 EVPL 2125
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 CSNK1E 1454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 ZNF581  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 DYNLL2 140735
Affinity Capture-MS Homo sapiens
79 Cdk5rap2  
Affinity Capture-MS Mus musculus
80 ZKSCAN3  
Two-hybrid Homo sapiens
81 PRPF31 26121
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 PRKACB 5567
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 CYLD  
Affinity Capture-MS Homo sapiens
84 JUP 3728
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ZBTB4 57659
Two-hybrid Homo sapiens
86 CALML3 810
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 FAM161A  
Two-hybrid Homo sapiens
88 EFNA4  
Affinity Capture-MS Homo sapiens
89 FAM129B 64855
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 IVL 3713
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 MIF4GD 57409
Two-hybrid Homo sapiens
92 TYMP 1890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 S100A7 6278
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 ZBTB24  
Two-hybrid Homo sapiens
95 HOXB5  
Two-hybrid Homo sapiens
96 S100A16 140576
Affinity Capture-MS Homo sapiens
97 AKAP9 10142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 RAB25 57111
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 IGKC 3514
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 C19orf66  
Two-hybrid Homo sapiens
101 CUL3 8452
Affinity Capture-MS Homo sapiens
102 PDE4D  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
103 MYOM1  
Two-hybrid Homo sapiens
104 OSGEP 55644
Two-hybrid Homo sapiens
105 CD207  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 SERPINB5 5268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 A2ML1 144568
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 CDK5RAP2 55755
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 MLF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 MAPRE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 PRKACA 5566
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
112 ARF6 382
Affinity Capture-MS Homo sapiens
113 NEFL 4747
Two-hybrid Homo sapiens
114 CYP2J2  
Affinity Capture-MS Homo sapiens
115 FCHSD2  
Two-hybrid Homo sapiens
116 EGFR 1956
Negative Genetic Homo sapiens
117 ZNF410  
Two-hybrid Homo sapiens
118 ZFYVE21  
Two-hybrid Homo sapiens
119 DNAJC10 54431
Affinity Capture-MS Homo sapiens
120 ZNF587  
Two-hybrid Homo sapiens
121 RNF2  
Affinity Capture-MS Homo sapiens
122 ZNF696  
Two-hybrid Homo sapiens
123 Prkar2a 19087
Affinity Capture-MS Mus musculus
124 Prkacb 18749
Affinity Capture-MS Mus musculus
125 SCCPDH 51097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 PKP3 11187
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 IMMT 10989
Two-hybrid Homo sapiens
128 KRT18 3875
Two-hybrid Homo sapiens
129 DVL2 1856
Affinity Capture-MS Homo sapiens
130 SNCA 6622
Two-hybrid Homo sapiens
131 FHL1 2273
Two-hybrid Homo sapiens
132 ZNF785  
Affinity Capture-MS Homo sapiens
133 SMN1 6606
Two-hybrid Homo sapiens
134 HAUS1  
Two-hybrid Homo sapiens
135 VAC14 55697
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
136 CCDC146  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
137 ACADVL 37
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 CRABP2 1382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 LGALS7B 653499
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 ZZEF1 23140
Affinity Capture-MS Homo sapiens
141 PFDN1 5201
Two-hybrid Homo sapiens
142 UTP14C  
Two-hybrid Homo sapiens
143 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
144 IGHG2 3501
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 CWF19L2  
Two-hybrid Homo sapiens
146 S100A9 6280
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 LOC338797  
Affinity Capture-MS Homo sapiens
148 PKP1 5317
Affinity Capture-MS Homo sapiens
149 PRKAR2B 5577
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 SERPINB3 6317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 UBE3C 9690
Affinity Capture-MS Homo sapiens
152 ITSN2 50618
Two-hybrid Homo sapiens
153 KDM1A 23028
Two-hybrid Homo sapiens
154 NEK2  
Two-hybrid Homo sapiens
155 Mapre1 13589
Affinity Capture-MS Mus musculus
156 CALML5 51806
Affinity Capture-MS Homo sapiens
157 GM2A 2760
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 Prkar2b 19088
Affinity Capture-MS Mus musculus
159 TEAD4  
Two-hybrid Homo sapiens
160 TGM1 7051
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 C1orf109  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
162 ADH1B 125
Two-hybrid Homo sapiens
163 ANKRD11 29123
Two-hybrid Homo sapiens
164 NCCRP1 342897
Affinity Capture-MS Homo sapiens
165 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 KRAS 3845
Two-hybrid Homo sapiens
167 SH2D4A 63898
Two-hybrid Homo sapiens
168 LCN2 3934
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 LIN37  
Two-hybrid Homo sapiens
170 GATM  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 CDC5L 988
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PDE4DIP is involved
No pathways found





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