Gene description for SCCPDH
Gene name saccharopine dehydrogenase (putative)
Gene symbol SCCPDH
Other names/aliases CGI-49
NET11
Species Homo sapiens
 Database cross references - SCCPDH
ExoCarta ExoCarta_51097
Vesiclepedia VP_51097
Entrez Gene 51097
HGNC 24275
UniProt Q8NBX0  
 SCCPDH identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SCCPDH
Molecular Function
    oxidoreductase activity GO:0016491 IEA
Biological Process
    glycolipid biosynthetic process GO:0009247 IBA
Subcellular Localization
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 HDA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    lipid droplet GO:0005811 IBA
    lipid droplet GO:0005811 IDA
    membrane GO:0016020 HDA
    midbody GO:0030496 IDA
    platelet alpha granule lumen GO:0031093 TAS
 Experiment description of studies that identified SCCPDH in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SCCPDH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COX5A 9377
Co-fractionation Homo sapiens
2 HACD3 51495
Co-fractionation Homo sapiens
3 TTYH1  
Affinity Capture-MS Homo sapiens
4 CABP2  
Affinity Capture-MS Homo sapiens
5 DNAJC11 55735
Co-fractionation Homo sapiens
6 RAB1A 5861
Co-fractionation Homo sapiens
7 PAXIP1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
8 USP13  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SLC39A4 55630
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ACOT9 23597
Co-fractionation Homo sapiens
11 MTX1 4580
Co-fractionation Homo sapiens
12 BZW2 28969
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 SLC25A13 10165
Co-fractionation Homo sapiens
14 IGHM 3507
Affinity Capture-MS Homo sapiens
15 MTMR14 64419
Affinity Capture-MS Homo sapiens
16 APOE 348
Co-fractionation Homo sapiens
17 NDUFS7 374291
Co-fractionation Homo sapiens
18 NDUFA4 4697
Affinity Capture-MS Homo sapiens
19 TAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PDHA1 5160
Co-fractionation Homo sapiens
21 NDUFS2 4720
Co-fractionation Homo sapiens
22 ATP5L 10632
Co-fractionation Homo sapiens
23 CPLX2 10814
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 APOA2 336
Affinity Capture-MS Homo sapiens
25 NDUFS3 4722
Co-fractionation Homo sapiens
26 B3GNT2 10678
Affinity Capture-MS Homo sapiens
27 OGDH 4967
Co-fractionation Homo sapiens
28 PRDX3 10935
Co-fractionation Homo sapiens
29 NDUFB8 4714
Co-fractionation Homo sapiens
30 COQ9  
Affinity Capture-MS Homo sapiens
31 COX7A2L 9167
Co-fractionation Homo sapiens
32 CYB5R1 51706
Co-fractionation Homo sapiens
33 GLRX 2745
Co-fractionation Homo sapiens
34 PGM1 5236
Co-fractionation Homo sapiens
35 MDH1 4190
Co-fractionation Homo sapiens
36 COA3 28958
Co-fractionation Homo sapiens
37 ATP5O 539
Co-fractionation Homo sapiens
38 MAGEA3  
Affinity Capture-MS Homo sapiens
39 C20orf24  
Co-fractionation Homo sapiens
40 HYPM  
Affinity Capture-MS Homo sapiens
41 NDUFV1 4723
Co-fractionation Homo sapiens
42 PHB 5245
Co-fractionation Homo sapiens
43 TOMM40 10452
Co-fractionation Homo sapiens
44 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
45 RAB6B 51560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 HSD17B4 3295
Co-fractionation Homo sapiens
47 ANKRD34C  
Co-fractionation Homo sapiens
48 UQCRQ 27089
Co-fractionation Homo sapiens
49 TMEM59 9528
Affinity Capture-MS Homo sapiens
50 NDUFS5 4725
Co-fractionation Homo sapiens
51 SLC25A3 5250
Co-fractionation Homo sapiens
52 IFT20 90410
Affinity Capture-MS Homo sapiens
53 PAM16  
Co-fractionation Homo sapiens
54 STOML2 30968
Co-fractionation Homo sapiens
55 LRRC59 55379
Co-fractionation Homo sapiens
56 OCIAD2 132299
Co-fractionation Homo sapiens
57 ATP5A1 498
Co-fractionation Homo sapiens
58 ENSA 2029
Affinity Capture-MS Homo sapiens
59 PARM1  
Affinity Capture-MS Homo sapiens
60 PPP6R2 9701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 NDUFA8 4702
Co-fractionation Homo sapiens
62 RAB4A 5867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 C12orf49  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 SLC25A20 788
Co-fractionation Homo sapiens
65 USMG5 84833
Co-fractionation Homo sapiens
66 C19orf26 255057
Affinity Capture-MS Homo sapiens
67 NTRK1 4914
Affinity Capture-MS Homo sapiens
68 CYC1 1537
Co-fractionation Homo sapiens
69 UQCRC1 7384
Co-fractionation Homo sapiens
70 ACTB 60
Co-fractionation Homo sapiens
71 TMEM160 54958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 AGPS 8540
Co-fractionation Homo sapiens
73 GNG5 2787
Co-fractionation Homo sapiens
74 VDAC2 7417
Co-fractionation Homo sapiens
75 NIPSNAP1 8508
Co-fractionation Homo sapiens
76 SEC61B 10952
Co-fractionation Homo sapiens
77 ATP5B 506
Co-fractionation Homo sapiens
78 DNAJB11 51726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 BZW1 9689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 COX4I1 1327
Co-fractionation Homo sapiens
81 TAL2  
Affinity Capture-MS Homo sapiens
82 HSPA5 3309
Co-fractionation Homo sapiens
83 CYB5B 80777
Affinity Capture-MS Homo sapiens
84 HADHB 3032
Co-fractionation Homo sapiens
85 HADHA 3030
Co-fractionation Homo sapiens
86 MINOS1  
Co-fractionation Homo sapiens
87 CANX 821
Co-fractionation Homo sapiens
88 ICAM1 3383
Co-fractionation Homo sapiens
89 RNF181  
Affinity Capture-MS Homo sapiens
90 C9orf78 51759
Affinity Capture-MS Homo sapiens
91 NDUFA9 4704
Co-fractionation Homo sapiens
92 KRT86  
Affinity Capture-MS Homo sapiens
93 LETM1 3954
Co-fractionation Homo sapiens
94 UQCRC2 7385
Co-fractionation Homo sapiens
95 CYB5R3 1727
Co-fractionation Homo sapiens
96 DDB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 TMEM258  
Affinity Capture-MS Homo sapiens
98 NIPAL1  
Affinity Capture-MS Homo sapiens
99 DCUN1D2 55208
Affinity Capture-MS Homo sapiens
100 MIEN1 84299
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 FAM63B 54629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 KBTBD7  
Affinity Capture-MS Homo sapiens
103 CORO1C 23603
Co-fractionation Homo sapiens
104 WAPAL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 OCIAD1 54940
Co-fractionation Homo sapiens
106 ZNF782  
Co-fractionation Homo sapiens
107 CPT2 1376
Co-fractionation Homo sapiens
108 SAAL1 113174
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 RPA3 6119
Proximity Label-MS Homo sapiens
110 COX6C 1345
Co-fractionation Homo sapiens
111 EMC2 9694
Co-fractionation Homo sapiens
112 SCGB2A2  
Affinity Capture-MS Homo sapiens
113 RPL35A 6165
Affinity Capture-MS Homo sapiens
114 RPN1 6184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 NDUFA3  
Co-fractionation Homo sapiens
116 VDAC1 7416
Co-fractionation Homo sapiens
117 COX2 4513
Co-fractionation Homo sapiens
118 HSPA9 3313
Co-fractionation Homo sapiens
119 PAIP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 NDUFC2 4718
Co-fractionation Homo sapiens
121 HTR3B  
Affinity Capture-MS Homo sapiens
122 FEZ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 PHB2 11331
Co-fractionation Homo sapiens
124 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
125 TOMM22 56993
Co-fractionation Homo sapiens
126 PGRMC1 10857
Affinity Capture-MS Homo sapiens
127 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 LDLRAD1  
Affinity Capture-MS Homo sapiens
129 PEX19 5824
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 HECTD3 79654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 POLE3  
Affinity Capture-MS Homo sapiens
132 ZZEF1 23140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 EMC4 51234
Co-fractionation Homo sapiens
134 SCGB3A1 92304
Affinity Capture-MS Homo sapiens
135 SQSTM1 8878
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 ACTR1B 10120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 FKBP9 11328
Co-fractionation Homo sapiens
138 PDHB 5162
Co-fractionation Homo sapiens
139 IL1R1 3554
Cross-Linking-MS (XL-MS) Homo sapiens
140 SFXN1 94081
Co-fractionation Homo sapiens
141 HAUS7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 ANXA13 312
Affinity Capture-MS Homo sapiens
143 MED21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 NDUFS8 4728
Co-fractionation Homo sapiens
145 MGST1 4257
Co-fractionation Homo sapiens
146 TOMM5  
Co-fractionation Homo sapiens
147 RAB7A 7879
Co-fractionation Homo sapiens
148 PCCB 5096
Co-fractionation Homo sapiens
149 RAB11A 8766
Co-fractionation Homo sapiens
150 PRDX1 5052
Co-fractionation Homo sapiens
151 COX7A2 1347
Co-fractionation Homo sapiens
152 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 PTGES3 10728
Affinity Capture-MS Homo sapiens
154 ATP5C1 509
Co-fractionation Homo sapiens
155 COX7C 1350
Co-fractionation Homo sapiens
156 VDAC3 7419
Co-fractionation Homo sapiens
157 SLC26A4 5172
Affinity Capture-MS Homo sapiens
158 DPAGT1 1798
Affinity Capture-MS Homo sapiens
159 C1orf74  
Affinity Capture-MS Homo sapiens
160 MGST3 4259
Co-fractionation Homo sapiens
161 MTCH2 23788
Co-fractionation Homo sapiens
View the network image/svg+xml



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