Gene description for HECTD3
Gene name HECT domain containing E3 ubiquitin protein ligase 3
Gene symbol HECTD3
Other names/aliases -
Species Homo sapiens
 Database cross references - HECTD3
ExoCarta ExoCarta_79654
Entrez Gene 79654
HGNC 26117
UniProt Q5T447  
 HECTD3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for HECTD3
Molecular Function
    protein binding GO:0005515 IPI
    syntaxin binding GO:0019905 IEA
    ubiquitin-protein transferase activity GO:0004842 ISS
    ligase activity GO:0016874 IEA
Biological Process
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    perinuclear region of cytoplasm GO:0048471 ISS
 Experiment description of studies that identified HECTD3 in exosomes
1
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HECTD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HECTD3 is involved
PathwayEvidenceSource
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome





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