Gene description for ANGPT2
Gene name angiopoietin 2
Gene symbol ANGPT2
Other names/aliases AGPT2
ANG2
Species Homo sapiens
 Database cross references - ANGPT2
ExoCarta ExoCarta_285
Vesiclepedia VP_285
Entrez Gene 285
HGNC 485
MIM 601922
UniProt O15123  
 ANGPT2 identified in exosomes derived from the following tissue/cell type
Plasma 34112803    
Plasma 34112803    
 Gene ontology annotations for ANGPT2
Molecular Function
    signaling receptor binding GO:0005102 TAS
    protein binding GO:0005515 IPI
    receptor tyrosine kinase binding GO:0030971 IBA
    receptor tyrosine kinase binding GO:0030971 IPI
    metal ion binding GO:0046872 IEA
    receptor ligand activity GO:0048018 IDA
Biological Process
    angiogenesis GO:0001525 IBA
    response to hypoxia GO:0001666 IEA
    signal transduction GO:0007165 TAS
    germ cell development GO:0007281 IEA
    blood coagulation GO:0007596 IEA
    response to mechanical stimulus GO:0009612 IEA
    response to glucose GO:0009749 IEA
    gene expression GO:0010467 IDA
    negative regulation of cell-substrate adhesion GO:0010812 IEA
    response to organic cyclic compound GO:0014070 IEA
    response to activity GO:0014823 IEA
    negative regulation of angiogenesis GO:0016525 IEA
    animal organ regeneration GO:0031100 IEA
    negative regulation of blood vessel endothelial cell migration GO:0043537 IDA
    positive regulation of angiogenesis GO:0045766 IEA
    Tie signaling pathway GO:0048014 IBA
    Tie signaling pathway GO:0048014 IDA
    positive regulation of coagulation GO:0050820 IDA
    negative regulation of positive chemotaxis GO:0050928 IDA
    maternal process involved in female pregnancy GO:0060135 IEA
    cellular response to growth factor stimulus GO:0071363 IEA
    glomerulus vasculature development GO:0072012 ISS
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 IDA
    cell projection GO:0042995 IEA
    collagen-containing extracellular matrix GO:0062023 IBA
 Experiment description of studies that identified ANGPT2 in exosomes
1
Experiment ID 525
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 34112803    
Organism Homo sapiens
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Plasma
Sample name Pooled plasma from healthy subjects
Isolation/purification methods Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
2
Experiment ID 526
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method ELISA
PubMed ID 34112803    
Organism Homo sapiens
Experiment description Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Authors "Lima LG, Ham S, Shin H, Chai EPZ, Lek ESH, Lobb RJ, Müller AF, Mathivanan S, Yeo B, Choi Y, Parker BS, Möller A. "
Journal name Nat Commun
Publication year 2021
Sample Plasma
Sample name Pooled plasma from breast cancer patients
Isolation/purification methods Size exclusion chromatography
Centrifugal ultrafiltration
Flotation density -
Molecules identified in the study Protein
Methods used in the study ELISA
 Protein-protein interactions for ANGPT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
2 TEK  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
3 IQCB1  
Affinity Capture-MS Homo sapiens
4 ANXA7 310
Two-hybrid Homo sapiens
5 ITGAV 3685
Affinity Capture-Western Homo sapiens
6 HECTD3 79654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ZZEF1 23140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ITGA5 3678
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 CSNK2B 1460
Two-hybrid Homo sapiens
10 FBXO28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CDKN1A  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ANGPT2 is involved
PathwayEvidenceSource
Cell surface interactions at the vascular wall TAS Reactome
Hemostasis TAS Reactome
Tie2 Signaling TAS Reactome





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