Gene description for SLC7A11
Gene name solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Gene symbol SLC7A11
Other names/aliases CCBR1
xCT
Species Homo sapiens
 Database cross references - SLC7A11
ExoCarta ExoCarta_23657
Entrez Gene 23657
HGNC 11059
MIM 607933
UniProt Q9UPY5  
 SLC7A11 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Prostate cancer cells 25844599    
 Gene ontology annotations for SLC7A11
Molecular Function
    cystine:glutamate antiporter activity GO:0015327 TAS
    protein binding GO:0005515 IPI
Biological Process
    brain development GO:0007420 IEA
    response to oxidative stress GO:0006979 IEA
    L-glutamate transmembrane transport GO:0089711 TAS
    response to toxic substance GO:0009636 IDA
    platelet aggregation GO:0070527 IEA
    leukocyte migration GO:0050900 TAS
    lens fiber cell differentiation GO:0070306 IEA
    blood coagulation GO:0007596 TAS
    transmembrane transport GO:0055085 TAS
    ion transport GO:0006811 TAS
    amino acid transport GO:0006865 TAS
    response to nicotine GO:0035094 IEA
Subcellular Localization
    integral component of membrane GO:0016021 TAS
    plasma membrane GO:0005886 TAS
    rough endoplasmic reticulum GO:0005791 IEA
    integral component of plasma membrane GO:0005887 IBA
    cytoskeleton GO:0005856 IEA
    cell surface GO:0009986 IDA
 Experiment description of studies that identified SLC7A11 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for SLC7A11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC3A2 6520
Invivo Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
2 BAAT  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLC7A11 is involved
PathwayEvidenceSource
Amino acid transport across the plasma membrane TAS Reactome
Basigin interactions TAS Reactome





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