Gene description for LYN
Gene name	LYN proto-oncogene, Src family tyrosine kinase
Gene symbol	LYN
Other names/aliases	JTK8 p53Lyn p56Lyn
Species	Homo sapiens
Database cross references - LYN
ExoCarta	ExoCarta_4067
Entrez Gene	4067
HGNC	6735
MIM	165120
UniProt	P07948
LYN identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Platelets	25332113
Platelets	25332113
Platelets	25332113
Prostate cancer cells	25844599
Prostate cancer cells	25844599
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for LYN

Molecular Function     ubiquitin protein ligase binding GO:0031625 IEA     ion channel binding GO:0044325 IPI     glycosphingolipid binding GO:0043208 IEA     receptor binding GO:0005102 IBA     platelet-derived growth factor receptor binding GO:0005161 IEA     integrin binding GO:0005178 IEA     SH3 domain binding GO:0017124 IEA     receptor signaling protein tyrosine kinase activity GO:0004716 TAS     protein binding GO:0005515 IPI     protein tyrosine kinase activity GO:0004713 TAS     phosphoprotein binding GO:0051219 IEA     non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS     enzyme binding GO:0019899 IPI     ATP binding GO:0005524 IEA Biological Process     positive regulation of cell proliferation GO:0008284 ISS     negative regulation of B cell proliferation GO:0030889 IBA     dendritic cell differentiation GO:0097028 ISS     cellular response to DNA damage stimulus GO:0006974 IDA     regulation of cytokine production GO:0001817 ISS     regulation of platelet aggregation GO:0090330 ISS     positive regulation of cellular component movement GO:0051272 IDA     signal transduction GO:0007165 TAS     histamine secretion by mast cell GO:0002553 IEA     regulation of cytokine secretion GO:0050707 IEA     positive regulation of oligodendrocyte progenitor proliferation GO:0070447 IEA     regulation of B cell apoptotic process GO:0002902 IBA     cytokine secretion GO:0050663 IEA     negative regulation of MAP kinase activity GO:0043407 ISS     regulation of mast cell activation GO:0033003 ISS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     cellular response to peptide hormone stimulus GO:0071375 IBA     positive regulation of glial cell proliferation GO:0060252 IEA     T cell costimulation GO:0031295 TAS     positive regulation of mast cell proliferation GO:0070668 IMP     negative regulation of intracellular signal transduction GO:1902532 ISS     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS     blood coagulation GO:0007596 TAS     B cell receptor signaling pathway GO:0050853 IEA     ephrin receptor signaling pathway GO:0048013 TAS     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     negative regulation of cell proliferation GO:0008285 IMP     positive regulation of dendritic cell apoptotic process GO:2000670 ISS     erythrocyte differentiation GO:0030218 ISS     positive regulation of neuron projection development GO:0010976 IMP     signal transduction by protein phosphorylation GO:0023014 TAS     Fc receptor mediated inhibitory signaling pathway GO:0002774 ISS     cellular response to extracellular stimulus GO:0031668 IEA     regulation of ERK1 and ERK2 cascade GO:0070372 ISS     positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 IEA     leukocyte migration GO:0050900 TAS     negative regulation of myeloid leukocyte differentiation GO:0002762 IEA     regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 ISS     regulation of erythrocyte differentiation GO:0045646 ISS     response to sterol depletion GO:0006991 IEA     negative regulation of toll-like receptor 2 signaling pathway GO:0034136 ISS     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     oligodendrocyte development GO:0014003 IEA     response to organic cyclic compound GO:0014070 IEA     immune response-regulating cell surface receptor signaling pathway GO:0002768 TAS     response to hormone GO:0009725 ISS     lipopolysaccharide-mediated signaling pathway GO:0031663 ISS     neuron projection development GO:0031175 IBA     response to carbohydrate GO:0009743 IEA     positive regulation of stress-activated protein kinase signaling cascade GO:0070304 IDA     negative regulation of protein phosphorylation GO:0001933 ISS     positive regulation of B cell receptor signaling pathway GO:0050861 IEA     negative regulation of mast cell proliferation GO:0070667 ISS     viral process GO:0016032 IEA     protein autophosphorylation GO:0046777 IDA     response to axon injury GO:0048678 IEA     response to amino acid GO:0043200 IEA     platelet degranulation GO:0002576 ISS     regulation of B cell receptor signaling pathway GO:0050855 ISS     regulation of cell adhesion mediated by integrin GO:0033628 IMP     response to insulin GO:0032868 IEA     JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS     B cell homeostasis GO:0001782 ISS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     positive regulation of cell migration GO:0030335 IEA     innate immune response GO:0045087 TAS     negative regulation of immune response GO:0050777 TAS     cellular response to heat GO:0034605 IEA     regulation of mast cell degranulation GO:0043304 ISS     tolerance induction to self antigen GO:0002513 TAS     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IMP     axon guidance GO:0007411 TAS     platelet activation GO:0030168 TAS     protein phosphorylation GO:0006468 IDA     Fc receptor mediated stimulatory signaling pathway GO:0002431 ISS     regulation of monocyte chemotaxis GO:0090025 IMP     Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS     cellular response to retinoic acid GO:0071300 IMP     negative regulation of toll-like receptor 4 signaling pathway GO:0034144 ISS     response to toxic substance GO:0009636 IEA     response to drug GO:0042493 IEA     regulation of inflammatory response GO:0050727 IEA     regulation of protein phosphorylation GO:0001932 TAS Subcellular Localization     mitochondrial crista GO:0030061 IEA     cytosol GO:0005829 TAS     mast cell granule GO:0042629 IEA     mitochondrial intermembrane space GO:0005758 IEA     nucleus GO:0005634 ISS     postsynaptic density GO:0014069 IEA     perinuclear region of cytoplasm GO:0048471 IDA     Golgi apparatus GO:0005794 IDA     extracellular exosome GO:0070062 IDA     integrin alpha2-beta1 complex GO:0034666 IEA     membrane raft GO:0045121 IDA     plasma membrane GO:0005886 TAS     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     cytoplasm GO:0005737 ISS