Gene description for LYN
Gene name LYN proto-oncogene, Src family tyrosine kinase
Gene symbol LYN
Other names/aliases JTK8
p53Lyn
p56Lyn
Species Homo sapiens
 Database cross references - LYN
ExoCarta ExoCarta_4067
Vesiclepedia VP_4067
Entrez Gene 4067
HGNC 6735
MIM 165120
UniProt P07948  
 LYN identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 34887515    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for LYN
Molecular Function
    protein tyrosine kinase activity GO:0004713 EXP
    protein tyrosine kinase activity GO:0004713 IDA
    protein tyrosine kinase activity GO:0004713 IMP
    protein tyrosine kinase activity GO:0004713 TAS
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IMP
    non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS
    signaling receptor binding GO:0005102 IBA
    platelet-derived growth factor receptor binding GO:0005161 IEA
    integrin binding GO:0005178 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    kinase activity GO:0016301 NAS
    SH3 domain binding GO:0017124 IEA
    enzyme binding GO:0019899 IPI
    ubiquitin protein ligase binding GO:0031625 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    gamma-tubulin binding GO:0043015 IEA
    glycosphingolipid binding GO:0043208 IEA
    transmembrane transporter binding GO:0044325 IPI
    ephrin receptor binding GO:0046875 IPI
    phosphoprotein binding GO:0051219 IEA
    scaffold protein binding GO:0097110 IPI
    phosphorylation-dependent protein binding GO:0140031 IPI
    histone H2AXY142 kinase activity GO:0140801 IEA
    phosphatidylinositol 3-kinase activator activity GO:0141038 IEA
Biological Process
    DNA damage checkpoint signaling GO:0000077 IDA
    cell morphogenesis GO:0000902 IEA
    B cell homeostasis GO:0001782 ISS
    regulation of cytokine production GO:0001817 ISS
    regulation of protein phosphorylation GO:0001932 TAS
    negative regulation of protein phosphorylation GO:0001933 ISS
    positive regulation of protein phosphorylation GO:0001934 IGI
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    hematopoietic progenitor cell differentiation GO:0002244 IMP
    adaptive immune response GO:0002250 IEA
    Fc receptor mediated stimulatory signaling pathway GO:0002431 IBA
    Fc receptor mediated stimulatory signaling pathway GO:0002431 ISS
    tolerance induction to self antigen GO:0002513 IBA
    tolerance induction to self antigen GO:0002513 ISS
    tolerance induction to self antigen GO:0002513 TAS
    histamine secretion by mast cell GO:0002553 IEA
    platelet degranulation GO:0002576 ISS
    negative regulation of myeloid leukocyte differentiation GO:0002762 IEA
    immune response-regulating cell surface receptor signaling pathway GO:0002768 ISS
    immune response-regulating cell surface receptor signaling pathway GO:0002768 TAS
    Fc receptor mediated inhibitory signaling pathway GO:0002774 ISS
    negative regulation of inflammatory response to antigenic stimulus GO:0002862 TAS
    regulation of B cell apoptotic process GO:0002902 IEA
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 IDA
    autophagy GO:0006914 IEA
    DNA damage response GO:0006974 IBA
    DNA damage response GO:0006974 IDA
    response to sterol depletion GO:0006991 IEA
    signal transduction GO:0007165 TAS
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA
    cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IMP
    positive regulation of cell population proliferation GO:0008284 ISS
    negative regulation of cell population proliferation GO:0008285 IMP
    response to xenobiotic stimulus GO:0009410 IEA
    response to toxic substance GO:0009636 IEA
    response to hormone GO:0009725 ISS
    response to carbohydrate GO:0009743 IEA
    positive regulation of neuron projection development GO:0010976 IMP
    oligodendrocyte development GO:0014003 IEA
    response to organic cyclic compound GO:0014070 IEA
    fatty acid transport GO:0015908 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IDA
    erythrocyte differentiation GO:0030218 ISS
    eosinophil differentiation GO:0030222 IDA
    positive regulation of cell migration GO:0030335 IEA
    negative regulation of B cell proliferation GO:0030889 IEA
    neuron projection development GO:0031175 IBA
    T cell costimulation GO:0031295 TAS
    lipopolysaccharide-mediated signaling pathway GO:0031663 ISS
    response to insulin GO:0032868 IEA
    regulation of mast cell activation GO:0033003 ISS
    regulation of cell adhesion mediated by integrin GO:0033628 IMP
    negative regulation of toll-like receptor 2 signaling pathway GO:0034136 ISS
    toll-like receptor 4 signaling pathway GO:0034142 IEA
    negative regulation of toll-like receptor 4 signaling pathway GO:0034144 ISS
    cellular response to heat GO:0034605 IEA
    interleukin-5-mediated signaling pathway GO:0038043 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS
    C-X-C chemokine receptor CXCR4 signaling pathway GO:0038159 IMP
    response to amino acid GO:0043200 IEA
    regulation of mast cell degranulation GO:0043304 ISS
    negative regulation of MAP kinase activity GO:0043407 ISS
    positive regulation of MAPK cascade GO:0043410 IDA
    regulation of erythrocyte differentiation GO:0045646 ISS
    protein autophosphorylation GO:0046777 IDA
    ephrin receptor signaling pathway GO:0048013 TAS
    response to axon injury GO:0048678 IEA
    negative regulation of immune response GO:0050777 TAS
    B cell receptor signaling pathway GO:0050853 IEA
    regulation of B cell receptor signaling pathway GO:0050855 IBA
    regulation of B cell receptor signaling pathway GO:0050855 ISS
    leukocyte migration GO:0050900 TAS
    regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA
    positive regulation of glial cell proliferation GO:0060252 IEA
    positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 IEA
    growth hormone receptor signaling pathway via JAK-STAT GO:0060397 TAS
    regulation of ERK1 and ERK2 cascade GO:0070372 ISS
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS
    positive regulation of oligodendrocyte progenitor proliferation GO:0070447 IEA
    negative regulation of mast cell proliferation GO:0070667 ISS
    positive regulation of mast cell proliferation GO:0070668 IMP
    cellular response to retinoic acid GO:0071300 IMP
    regulation of monocyte chemotaxis GO:0090025 IMP
    regulation of platelet aggregation GO:0090330 ISS
    dendritic cell differentiation GO:0097028 IBA
    dendritic cell differentiation GO:0097028 ISS
    neuroinflammatory response GO:0150076 IEA
    negative regulation of intracellular signal transduction GO:1902532 ISS
    positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961 IMP
    positive regulation of dendritic cell apoptotic process GO:2000670 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISS
    lysosomal membrane GO:0005765 TAS
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    adherens junction GO:0005912 IEA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    mitochondrial crista GO:0030061 IEA
    endocytic vesicle membrane GO:0030666 TAS
    integrin alpha2-beta1 complex GO:0034666 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    membrane raft GO:0045121 IDA
    membrane raft GO:0045121 ISS
    perinuclear region of cytoplasm GO:0048471 IDA
    extracellular exosome GO:0070062 HDA
    glutamatergic synapse GO:0098978 IEA
    postsynaptic specialization, intracellular component GO:0099091 IEA
 Experiment description of studies that identified LYN in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 282
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
6
Experiment ID 283
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
7
Experiment ID 285
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
8
Experiment ID 286
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
9
Experiment ID 1203
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
10
Experiment ID 1275
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 1280
MISEV standards
Biophysical techniques
✔ Enriched markers
✔ Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 255
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 256
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 257
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 258
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 259
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 260
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
22
Experiment ID 224
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
23
Experiment ID 211
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
24
Experiment ID 212
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
26
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
27
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
28
Experiment ID 275
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
29
Experiment ID 274
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
30
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
31
Experiment ID 217
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✔ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LYN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Proximity Label-MS Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 WDR6 11180
Proximity Label-MS Homo sapiens
4 UTRN 7402
Proximity Label-MS Homo sapiens
5 RASSF8 11228
Proximity Label-MS Homo sapiens
6 SLC1A5 6510
Proximity Label-MS Homo sapiens
7 SHC1 6464
Affinity Capture-Western Homo sapiens
8 LLGL1 3996
Proximity Label-MS Homo sapiens
9 PKP2 5318
Proximity Label-MS Homo sapiens
10 CD72  
Biochemical Activity Homo sapiens
11 Calml3  
Affinity Capture-MS Mus musculus
12 SH3RF1  
Proximity Label-MS Homo sapiens
13 KIF20A 10112
Affinity Capture-MS Homo sapiens
14 BRD2  
Proximity Label-MS Homo sapiens
15 MAP4K4 9448
Proximity Label-MS Homo sapiens
16 BPNT1 10380
Affinity Capture-MS Homo sapiens
17 PRKDC 5591
Reconstituted Complex Homo sapiens
18 ANKRD50 57182
Proximity Label-MS Homo sapiens
19 SEPT9 10801
Proximity Label-MS Homo sapiens
20 DHX33  
Proximity Label-MS Homo sapiens
21 RBM28 55131
Proximity Label-MS Homo sapiens
22 ABLIM1 3983
Proximity Label-MS Homo sapiens
23 NDRG1 10397
Proximity Label-MS Homo sapiens
24 RNF8  
Co-fractionation Homo sapiens
25 PACS1 55690
Proximity Label-MS Homo sapiens
26 UNC5B 219699
Proximity Label-MS Homo sapiens
27 SRC 6714
Protein-peptide Homo sapiens
28 FAM206A  
Affinity Capture-MS Homo sapiens
29 ABI1 10006
Proximity Label-MS Homo sapiens
30 OCLN 100506658
Proximity Label-MS Homo sapiens
31 MARCKSL1 65108
Proximity Label-MS Homo sapiens
32 F2RL1  
Affinity Capture-MS Homo sapiens
33 NMT1 4836
Biochemical Activity Homo sapiens
34 SLC12A7 10723
Proximity Label-MS Homo sapiens
35 TFRC 7037
Proximity Label-MS Homo sapiens
36 TRPV4 59341
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
37 DYNLT1 6993
Proximity Label-MS Homo sapiens
38 EXOC3 11336
Proximity Label-MS Homo sapiens
39 NOTCH2 4853
Proximity Label-MS Homo sapiens
40 KIDINS220 57498
Proximity Label-MS Homo sapiens
41 NEDD9 4739
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
42 OSGEPL1  
Co-fractionation Homo sapiens
43 FASLG 356
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
44 SH3BP4 23677
Proximity Label-MS Homo sapiens
45 CNNM3 26505
Proximity Label-MS Homo sapiens
46 CSF1R  
Affinity Capture-Western Homo sapiens
47 MCAM 4162
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
48 EFR3B  
Proximity Label-MS Homo sapiens
49 CERS2 29956
Affinity Capture-MS Homo sapiens
50 RPS6KB1 6198
Biochemical Activity Homo sapiens
51 YAP1 10413
Affinity Capture-MS Homo sapiens
52 MYH9 4627
Affinity Capture-MS Homo sapiens
53 TYK2 7297
Reconstituted Complex Homo sapiens
54 PDE8A 5151
Proximity Label-MS Homo sapiens
55 JPH1 56704
Proximity Label-MS Homo sapiens
56 FNBP1 23048
Proximity Label-MS Homo sapiens
57 Coro1c 23790
Affinity Capture-MS Mus musculus
58 MPP7 143098
Proximity Label-MS Homo sapiens
59 EPB41L5 57669
Proximity Label-MS Homo sapiens
60 DDX39B 7919
Affinity Capture-MS Homo sapiens
61 FLOT2 2319
Proximity Label-MS Homo sapiens
62 IQGAP2 10788
Proximity Label-MS Homo sapiens
63 TRIM63  
Two-hybrid Homo sapiens
64 PARD3 56288
Proximity Label-MS Homo sapiens
65 ANLN 54443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 DST 667
Proximity Label-MS Homo sapiens
67 CSNK1G3 1456
Proximity Label-MS Homo sapiens
68 PALM2  
Proximity Label-MS Homo sapiens
69 EPB41L1 2036
Proximity Label-MS Homo sapiens
70 ARHGAP32  
Proximity Label-MS Homo sapiens
71 FAM83B  
Proximity Label-MS Homo sapiens
72 FAM129B 64855
Proximity Label-MS Homo sapiens
73 AHCYL1 10768
Proximity Label-MS Homo sapiens
74 CDCA3 83461
Proximity Label-MS Homo sapiens
75 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
76 ROBO1 6091
Proximity Label-MS Homo sapiens
77 ERBB2IP 55914
Proximity Label-MS Homo sapiens
78 DLG1 1739
Proximity Label-MS Homo sapiens
79 FRMPD4  
Proximity Label-MS Homo sapiens
80 LMTK2 22853
Proximity Label-MS Homo sapiens
81 ERBB4 2066
Reconstituted Complex Homo sapiens
82 RRP15  
Proximity Label-MS Homo sapiens
83 SNX9 51429
Proximity Label-MS Homo sapiens
84 CCNL2 81669
Affinity Capture-MS Homo sapiens
85 MFAP1  
Proximity Label-MS Homo sapiens
86 CSF3R  
Affinity Capture-Western Homo sapiens
87 LTV1  
Proximity Label-MS Homo sapiens
88 IGSF3 3321
Proximity Label-MS Homo sapiens
89 ABCC1 4363
Proximity Label-MS Homo sapiens
90 MPZL1 9019
Proximity Label-MS Homo sapiens
91 DZIP1  
Proximity Label-MS Homo sapiens
92 CTNNA1 1495
Proximity Label-MS Homo sapiens
93 BANK1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
94 INPP5D 3635
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
95 EFNB2 1948
Proximity Label-MS Homo sapiens
96 EPHB3 2049
Proximity Label-MS Homo sapiens
97 CDC42EP4  
Proximity Label-MS Homo sapiens
98 DDX55  
Proximity Label-MS Homo sapiens
99 RPS3A 6189
Proximity Label-MS Homo sapiens
100 FLVCR1 28982
Proximity Label-MS Homo sapiens
101 ADCY3 109
Proximity Label-MS Homo sapiens
102 GPRIN3  
Proximity Label-MS Homo sapiens
103 PSD3 23362
Proximity Label-MS Homo sapiens
104 GAB3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
105 RAB11FIP5 26056
Proximity Label-MS Homo sapiens
106 MACF1 23499
Proximity Label-MS Homo sapiens
107 MTA1 9112
Proximity Label-MS Homo sapiens
108 IL1B  
Reconstituted Complex Homo sapiens
109 RASA3 22821
Proximity Label-MS Homo sapiens
110 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
111 STK38L 23012
Affinity Capture-MS Homo sapiens
112 H2AFY 9555
Proximity Label-MS Homo sapiens
113 RAB11FIP1 80223
Proximity Label-MS Homo sapiens
114 ITGA2 3673
Proximity Label-MS Homo sapiens
115 SKAP1 8631
Reconstituted Complex Homo sapiens
116 RAB2A 5862
Proximity Label-MS Homo sapiens
117 PHACTR4 65979
Proximity Label-MS Homo sapiens
118 CDK4 1019
Affinity Capture-MS Homo sapiens
119 C1orf21  
Proximity Label-MS Homo sapiens
120 PLEKHA7 144100
Proximity Label-MS Homo sapiens
121 EPHA2 1969
Proximity Label-MS Homo sapiens
122 RAB5C 5878
Proximity Label-MS Homo sapiens
123 BLNK  
Affinity Capture-MS Homo sapiens
124 VANGL1 81839
Proximity Label-MS Homo sapiens
125 PHF8  
Proximity Label-MS Homo sapiens
126 CTNND1 1500
Proximity Label-MS Homo sapiens
127 KIF23 9493
Affinity Capture-MS Homo sapiens
128 KLC2 64837
Affinity Capture-MS Homo sapiens
129 ARHGAP39  
Proximity Label-MS Homo sapiens
130 LAMP3  
Proximity Label-MS Homo sapiens
131 BTF3 689
Affinity Capture-MS Homo sapiens
132 APC  
Proximity Label-MS Homo sapiens
133 RASAL2 9462
Proximity Label-MS Homo sapiens
134 DTNA  
Proximity Label-MS Homo sapiens
135 SMARCA1 6594
Proximity Label-MS Homo sapiens
136 CNP 1267
Proximity Label-MS Homo sapiens
137 FMN2  
Proximity Label-MS Homo sapiens
138 VAMP2 6844
Proximity Label-MS Homo sapiens
139 TBC1D8  
Proximity Label-MS Homo sapiens
140 PLCH1  
Proximity Label-MS Homo sapiens
141 EVL 51466
Reconstituted Complex Homo sapiens
142 VANGL2  
Proximity Label-MS Homo sapiens
143 RGS16 6004
Biochemical Activity Homo sapiens
144 GP1BB 2812
Affinity Capture-Western Homo sapiens
145 CTLA4  
Affinity Capture-Western Homo sapiens
146 IQGAP1 8826
Proximity Label-MS Homo sapiens
147 MUC1 4582
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
148 TNIK 23043
Proximity Label-MS Homo sapiens
149 MAP4K5 11183
Proximity Label-MS Homo sapiens
150 KHDRBS1 10657
Protein-peptide Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
151 SYK 6850
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
152 C11orf52 91894
Proximity Label-MS Homo sapiens
153 STEAP3 55240
Proximity Label-MS Homo sapiens
154 PTK7 5754
Proximity Label-MS Homo sapiens
155 PTPN14 5784
Proximity Label-MS Homo sapiens
156 MPP1 4354
Proximity Label-MS Homo sapiens
157 PALM 5064
Proximity Label-MS Homo sapiens
158 SLC7A11 23657
Proximity Label-MS Homo sapiens
159 PTPRC 5788
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
160 PES1 23481
Proximity Label-MS Homo sapiens
161 LMAN1 3998
Proximity Label-MS Homo sapiens
162 SDK2 54549
Proximity Label-MS Homo sapiens
163 MAPK3 5595
Affinity Capture-Western Homo sapiens
164 WHSC1 7468
Proximity Label-MS Homo sapiens
165 CCDC88C 440193
Proximity Label-MS Homo sapiens
166 RAI14 26064
Proximity Label-MS Homo sapiens
167 LYN 4067
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
168 CBL 867
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
169 SNAP47 116841
Proximity Label-MS Homo sapiens
170 CSF2RB  
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
171 ADD2 119
Proximity Label-MS Homo sapiens
172 CD24 100133941
Affinity Capture-Western Homo sapiens
173 RELL1 768211
Proximity Label-MS Homo sapiens
174 SCARB1 949
Proximity Label-MS Homo sapiens
175 PTK2B 2185
Affinity Capture-Western Homo sapiens
176 REXO4  
Proximity Label-MS Homo sapiens
177 RAP1A 5906
Proximity Label-MS Homo sapiens
178 KCNB2  
Proximity Label-MS Homo sapiens
179 FCAR  
Affinity Capture-Western Homo sapiens
180 TANC1 85461
Proximity Label-MS Homo sapiens
181 MINK1 50488
Proximity Label-MS Homo sapiens
182 MARVELD2 153562
Proximity Label-MS Homo sapiens
183 KANK2 25959
Proximity Label-MS Homo sapiens
184 NDFIP2 54602
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
185 ADCY9 115
Proximity Label-MS Homo sapiens
186 CDC42EP1 11135
Proximity Label-MS Homo sapiens
187 PHIP 55023
Proximity Label-MS Homo sapiens
188 DAB2IP 153090
Proximity Label-MS Homo sapiens
189 RICTOR 253260
Proximity Label-MS Homo sapiens
190 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
191 FARP2 9855
Proximity Label-MS Homo sapiens
192 PTK2 5747
Affinity Capture-Western Homo sapiens
193 FTH1 2495
Affinity Capture-MS Homo sapiens
194 SPTBN1 6711
Proximity Label-MS Homo sapiens
195 GAB1  
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
196 PLEKHA5 54477
Proximity Label-MS Homo sapiens
197 SLC7A5 8140
Proximity Label-MS Homo sapiens
198 PCDH7 5099
Proximity Label-MS Homo sapiens
199 CDK2 1017
Affinity Capture-Western Homo sapiens
200 FGFR2 2263
Affinity Capture-Western Homo sapiens
201 MYC  
Affinity Capture-MS Homo sapiens
202 SLC3A2 6520
Proximity Label-MS Homo sapiens
203 PKP4 8502
Proximity Label-MS Homo sapiens
204 MICALL1 85377
Proximity Label-MS Homo sapiens
205 BLMH 642
Affinity Capture-MS Homo sapiens
206 MET 4233
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
207 FCGR2B  
Reconstituted Complex Homo sapiens
208 AHNAK2 113146
Proximity Label-MS Homo sapiens
209 SLC12A6 9990
Proximity Label-MS Homo sapiens
210 RHOB 388
Proximity Label-MS Homo sapiens
211 PGAM1 5223
Co-fractionation Homo sapiens
212 CCDC88A 55704
Proximity Label-MS Homo sapiens
213 CPNE8 144402
Proximity Label-MS Homo sapiens
214 LRRC16A 55604
Proximity Label-MS Homo sapiens
215 CBLC  
Reconstituted Complex Homo sapiens
216 SLC16A1 6566
Proximity Label-MS Homo sapiens
217 DENND4C 55667
Proximity Label-MS Homo sapiens
218 MARK3 4140
Proximity Label-MS Homo sapiens
219 CLPP 8192
Proximity Label-MS Homo sapiens
220 FGR 2268
Proximity Label-MS Homo sapiens
221 TMEM51 55092
Proximity Label-MS Homo sapiens
222 PLXNB2 23654
Proximity Label-MS Homo sapiens
223 SLC38A2 54407
Proximity Label-MS Homo sapiens
224 KIF14 9928
Affinity Capture-MS Homo sapiens
225 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
226 EXOSC9 5393
Proximity Label-MS Homo sapiens
227 XPR1 9213
Proximity Label-MS Homo sapiens
228 FCGR2A 2212
Affinity Capture-Western Homo sapiens
229 CDK1 983
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
230 PRAM1  
Affinity Capture-Western Homo sapiens
231 Myh10 77579
Affinity Capture-MS Mus musculus
232 EPHA3 2042
Proximity Label-MS Homo sapiens
233 EPB41L3 23136
Proximity Label-MS Homo sapiens
234 KIAA0754  
Proximity Label-MS Homo sapiens
235 NF2 4771
Proximity Label-MS Homo sapiens
236 ATP1A1 476
Proximity Label-MS Homo sapiens
237 TUBD1  
Affinity Capture-MS Homo sapiens
238 YKT6 10652
Proximity Label-MS Homo sapiens
239 ARF1 375
Proximity Label-MS Homo sapiens
240 C2CD5 9847
Proximity Label-MS Homo sapiens
241 KRAS 3845
Proximity Label-MS Homo sapiens
242 ARAP2  
Proximity Label-MS Homo sapiens
243 IRS4 8471
Proximity Label-MS Homo sapiens
244 JAK2 3717
Reconstituted Complex Homo sapiens
245 RAB23 51715
Proximity Label-MS Homo sapiens
246 PTPRG 5793
Proximity Label-MS Homo sapiens
247 DLG5 9231
Proximity Label-MS Homo sapiens
248 ZDHHC5 25921
Proximity Label-MS Homo sapiens
249 ANK2 287
Proximity Label-MS Homo sapiens
250 PPIAL4G  
Affinity Capture-MS Homo sapiens
251 CD99 4267
Proximity Label-MS Homo sapiens
252 MARCKS 4082
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
253 WASF2 10163
Proximity Label-MS Homo sapiens
254 EFR3A 23167
Proximity Label-MS Homo sapiens
255 MME 4311
Affinity Capture-Western Homo sapiens
256 SLC30A1 7779
Proximity Label-MS Homo sapiens
257 PDE4A 5141
Reconstituted Complex Homo sapiens
258 ADGRL2 23266
Proximity Label-MS Homo sapiens
259 FLT3  
Affinity Capture-Western Homo sapiens
260 ADD3 120
Proximity Label-MS Homo sapiens
261 SHB 6461
Proximity Label-MS Homo sapiens
262 TOX3  
Proximity Label-MS Homo sapiens
263 FUBP3 8939
Proximity Label-MS Homo sapiens
264 USP6NL 9712
Proximity Label-MS Homo sapiens
265 RPS6KB2  
Biochemical Activity Homo sapiens
266 CEP97 79598
Affinity Capture-MS Homo sapiens
267 PI4KA 5297
Proximity Label-MS Homo sapiens
268 TRIM28 10155
Biochemical Activity Homo sapiens
269 MLLT4 4301
Proximity Label-MS Homo sapiens
270 PAK4 10298
Proximity Label-MS Homo sapiens
271 FAM171A2 284069
Proximity Label-MS Homo sapiens
272 NUMBL 9253
Proximity Label-MS Homo sapiens
273 CXADR 1525
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
274 DSC2 1824
Proximity Label-MS Homo sapiens
275 DMD 1756
Proximity Label-MS Homo sapiens
276 PHLDB2 90102
Proximity Label-MS Homo sapiens
277 PLD1 5337
Proximity Label-MS Homo sapiens
278 EPOR  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
279 ATG7 10533
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
280 STXBP3 6814
Proximity Label-MS Homo sapiens
281 DDX18 8886
Proximity Label-MS Homo sapiens
282 ATG16L1 55054
Affinity Capture-MS Homo sapiens
283 SLC19A1 6573
Proximity Label-MS Homo sapiens
284 SNAP23 8773
Proximity Label-MS Homo sapiens
285 TFCP2 7024
Affinity Capture-MS Homo sapiens
286 ESYT2 57488
Proximity Label-MS Homo sapiens
287 ATP13A3 79572
Proximity Label-MS Homo sapiens
288 CSNK2B 1460
Two-hybrid Homo sapiens
289 GPRIN1 114787
Proximity Label-MS Homo sapiens
290 LAMP1 3916
Proximity Label-MS Homo sapiens
291 PLEKHA1 59338
Proximity Label-MS Homo sapiens
292 Rab11fip1  
Affinity Capture-MS Mus musculus
293 BSG 682
Proximity Label-MS Homo sapiens
294 KIAA1217 56243
Proximity Label-MS Homo sapiens
295 SLC1A3 6507
Proximity Label-MS Homo sapiens
296 BCAR1 9564
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
297 KIT 3815
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
298 PARK2  
Affinity Capture-MS Homo sapiens
299 IGF1R 3480
Proximity Label-MS Homo sapiens
300 CENPV 201161
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
301 SKAP2 8935
Affinity Capture-Western Homo sapiens
302 RPL5 6125
Proximity Label-MS Homo sapiens
303 NUMB 8650
Proximity Label-MS Homo sapiens
304 DIRAS3  
Proximity Label-MS Homo sapiens
305 NTRK1 4914
Affinity Capture-MS Homo sapiens
306 HIST1H1E 3008
Proximity Label-MS Homo sapiens
307 ARNT 405
Affinity Capture-MS Homo sapiens
308 CCDC8  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
309 SLC6A6 6533
Proximity Label-MS Homo sapiens
310 UNC119 9094
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
311 PIK3R1 5295
Proximity Label-MS Homo sapiens
312 SNAPC1  
Affinity Capture-MS Homo sapiens
313 ARL13B 200894
Proximity Label-MS Homo sapiens
314 MYBBP1A 10514
Proximity Label-MS Homo sapiens
315 PECAM1 5175
Affinity Capture-Western Homo sapiens
316 HCLS1 3059
Affinity Capture-Western Homo sapiens
317 TMEM185A  
Affinity Capture-MS Homo sapiens
318 SLC4A7 9497
Proximity Label-MS Homo sapiens
319 PRRG4  
Reconstituted Complex Homo sapiens
320 HOXB5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
321 FERMT2 10979
Proximity Label-MS Homo sapiens
322 VAMP3 9341
Proximity Label-MS Homo sapiens
323 PHF2  
Proximity Label-MS Homo sapiens
324 PDE4D  
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
325 UHRF2  
Far Western Homo sapiens
326 Pde4d  
Affinity Capture-Western Rattus norvegicus
327 BAIAP2L1 55971
Proximity Label-MS Homo sapiens
328 KIF26B  
Proximity Label-MS Homo sapiens
329 CDC42BPA 8476
Proximity Label-MS Homo sapiens
330 MYO1D 4642
Proximity Label-MS Homo sapiens
331 Flnb 286940
Affinity Capture-MS Mus musculus
332 PTPN13 5783
Proximity Label-MS Homo sapiens
333 EPB41 2035
Proximity Label-MS Homo sapiens
334 SH3D19 152503
Proximity Label-MS Homo sapiens
335 SLC6A15 55117
Proximity Label-MS Homo sapiens
336 SEPT7 989
Proximity Label-MS Homo sapiens
337 HLA-A 3105
Proximity Label-MS Homo sapiens
338 TSR1 55720
Proximity Label-MS Homo sapiens
339 ATP7A 538
Proximity Label-MS Homo sapiens
340 CASKIN2  
Proximity Label-MS Homo sapiens
341 PIP5K1A 8394
Proximity Label-MS Homo sapiens
342 DEPDC1B 55789
Proximity Label-MS Homo sapiens
343 TOP2B 7155
Proximity Label-MS Homo sapiens
344 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
345 PVRL2 5819
Proximity Label-MS Homo sapiens
346 EPB41L4B 54566
Proximity Label-MS Homo sapiens
347 ITSN1 6453
Proximity Label-MS Homo sapiens
348 JUP 3728
Proximity Label-MS Homo sapiens
349 SPTBN2 6712
Proximity Label-MS Homo sapiens
350 FAM171B  
Proximity Label-MS Homo sapiens
351 LSR 51599
Proximity Label-MS Homo sapiens
352 EPHA4 2043
Proximity Label-MS Homo sapiens
353 PLXNA1 5361
Proximity Label-MS Homo sapiens
354 IKBKG 8517
Affinity Capture-Western Homo sapiens
355 EFNB1 1947
Proximity Label-MS Homo sapiens
356 CLYBL  
Co-fractionation Homo sapiens
357 CREBBP  
Reconstituted Complex Homo sapiens
358 ZDHHC23  
Affinity Capture-MS Homo sapiens
359 ERGIC1 57222
Proximity Label-MS Homo sapiens
360 GAB2 9846
Affinity Capture-Western Homo sapiens
361 NF1 4763
Proximity Label-MS Homo sapiens
362 PPP1R9A  
Proximity Label-MS Homo sapiens
363 PPP1R13B  
Proximity Label-MS Homo sapiens
364 MARK2 2011
Proximity Label-MS Homo sapiens
365 FRS2 10818
Proximity Label-MS Homo sapiens
366 ROBO2 6092
Proximity Label-MS Homo sapiens
367 LCP2 3937
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
368 MYO1E 4643
Proximity Label-MS Homo sapiens
369 EHBP1 23301
Proximity Label-MS Homo sapiens
370 CYFIP1 23191
Proximity Label-MS Homo sapiens
371 AR 367
Reconstituted Complex Homo sapiens
372 RBM34  
Proximity Label-MS Homo sapiens
373 CAV1 857
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
374 NOTCH1 4851
Proximity Label-MS Homo sapiens
375 IGF2BP2 10644
Proximity Label-MS Homo sapiens
376 LRRC1 55227
Proximity Label-MS Homo sapiens
377 ILDR2  
Proximity Label-MS Homo sapiens
378 ARHGAP21 57584
Proximity Label-MS Homo sapiens
379 SLC29A1 2030
Proximity Label-MS Homo sapiens
380 RNASEH2B  
Proximity Label-MS Homo sapiens
381 RFTN1 23180
Proximity Label-MS Homo sapiens
382 CDC42BPB 9578
Proximity Label-MS Homo sapiens
383 CEP89 84902
Proximity Label-MS Homo sapiens
384 AKAP12 9590
Proximity Label-MS Homo sapiens
385 RACGAP1 29127
Proximity Label-MS Homo sapiens
386 SPECC1 92521
Proximity Label-MS Homo sapiens
387 LPHN1  
Proximity Label-MS Homo sapiens
388 MED9  
Affinity Capture-MS Homo sapiens
389 VPS13A 23230
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
390 RPL10 6134
Reconstituted Complex Homo sapiens
391 SOCS1  
Biochemical Activity Homo sapiens
392 LAMP2 3920
Proximity Label-MS Homo sapiens
393 BASP1 10409
Proximity Label-MS Homo sapiens
394 TRIM55  
Two-hybrid Homo sapiens
395 LNPEP 4012
Proximity Label-MS Homo sapiens
396 INCENP 3619
Proximity Label-MS Homo sapiens
397 PHC3  
Proximity Label-MS Homo sapiens
398 SLC12A2 6558
Proximity Label-MS Homo sapiens
399 USP31 57478
Proximity Label-MS Homo sapiens
400 RPS20 6224
Proximity Label-MS Homo sapiens
401 B3GAT1  
Proximity Label-MS Homo sapiens
402 PLCG2 5336
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
403 SLC39A14 23516
Proximity Label-MS Homo sapiens
404 SLC39A10 57181
Proximity Label-MS Homo sapiens
405 WDR20 91833
Proximity Label-MS Homo sapiens
406 TSNAX 7257
Affinity Capture-MS Homo sapiens
407 YES1 7525
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
408 SCRIB 23513
Proximity Label-MS Homo sapiens
409 PIK3CG  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
410 ADD1 118
Proximity Label-MS Homo sapiens
411 TIAM1  
Proximity Label-MS Homo sapiens
412 FMNL2 114793
Proximity Label-MS Homo sapiens
413 ABCE1 6059
Affinity Capture-MS Homo sapiens
414 MYO1B 4430
Proximity Label-MS Homo sapiens
415 PEAK1 79834
Proximity Label-MS Homo sapiens
416 CDCA8 55143
Proximity Label-MS Homo sapiens
417 RAB35 11021
Proximity Label-MS Homo sapiens
418 ERBB2 2064
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
419 TMEM2 23670
Proximity Label-MS Homo sapiens
420 RLIM 51132
Affinity Capture-MS Homo sapiens
421 CD22 933
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
422 LAMTOR1 55004
Proximity Label-MS Homo sapiens
423 TNF  
Reconstituted Complex Homo sapiens
424 CASK 8573
Proximity Label-MS Homo sapiens
425 COBLL1 22837
Proximity Label-MS Homo sapiens
426 SEMA4C 54910
Proximity Label-MS Homo sapiens
427 ARHGAP12  
Proximity Label-MS Homo sapiens
428 POLD1 5424
Affinity Capture-MS Homo sapiens
429 COASY 80347
Biochemical Activity Homo sapiens
430 ERBB3 2065
Reconstituted Complex Homo sapiens
431 TNKS1BP1 85456
Proximity Label-MS Homo sapiens
432 TEC 7006
Affinity Capture-Western Homo sapiens
433 SCAMP1 9522
Proximity Label-MS Homo sapiens
434 GJB7  
Affinity Capture-MS Homo sapiens
435 PAG1 55824
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
436 NOC2L 26155
Proximity Label-MS Homo sapiens
437 NAP1L4 4676
Proximity Label-MS Homo sapiens
438 C19orf26 255057
Proximity Label-MS Homo sapiens
439 PPP1R8 5511
Biochemical Activity Homo sapiens
440 FAM135A  
Proximity Label-MS Homo sapiens
441 SLC7A2 6542
Proximity Label-MS Homo sapiens
442 TULP3 7289
Proximity Label-MS Homo sapiens
443 ULK1  
Co-fractionation Homo sapiens
444 MTMR1 8776
Proximity Label-MS Homo sapiens
445 BTK 695
Reconstituted Complex Homo sapiens
446 ATP2B4 493
Proximity Label-MS Homo sapiens
447 TBC1D10B 26000
Proximity Label-MS Homo sapiens
448 ANKRD26 22852
Proximity Label-MS Homo sapiens
449 FGFR1OP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
450 Slain1  
Affinity Capture-MS Mus musculus
451 CTNNAL1 8727
Proximity Label-MS Homo sapiens
452 SNAP29 9342
Proximity Label-MS Homo sapiens
453 STK10 6793
Proximity Label-MS Homo sapiens
454 LIMA1 51474
Affinity Capture-MS Homo sapiens
455 CACHD1  
Proximity Label-MS Homo sapiens
456 IPO5 3843
Proximity Label-MS Homo sapiens
457 RPL7A 6130
Proximity Label-MS Homo sapiens
458 PTPN6 5777
Reconstituted Complex Homo sapiens
459 SLC39A6 25800
Proximity Label-MS Homo sapiens
460 DOCK7 85440
Proximity Label-MS Homo sapiens
461 ATP2B1 490
Proximity Label-MS Homo sapiens
462 SLC20A2 6575
Proximity Label-MS Homo sapiens
463 CTNNB1 1499
Proximity Label-MS Homo sapiens
464 FAM171A1 221061
Proximity Label-MS Homo sapiens
465 TRIO 7204
Proximity Label-MS Homo sapiens
466 CCP110  
Affinity Capture-MS Homo sapiens
467 RNF138  
Affinity Capture-MS Homo sapiens
468 ARF6 382
Proximity Label-MS Homo sapiens
469 NAP1L1 4673
Proximity Label-MS Homo sapiens
470 UACA 55075
Proximity Label-MS Homo sapiens
471 SLC25A41  
Affinity Capture-MS Homo sapiens
472 EPHA7 2045
Proximity Label-MS Homo sapiens
473 LZTS2 84445
Proximity Label-MS Homo sapiens
474 KIRREL 55243
Proximity Label-MS Homo sapiens
475 ACSL3 2181
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
476 MYO6 4646
Proximity Label-MS Homo sapiens
477 FCHO2 115548
Proximity Label-MS Homo sapiens
478 AKAP5  
Proximity Label-MS Homo sapiens
479 AKT2 208
Proximity Label-MS Homo sapiens
480 PPFIBP1 8496
Proximity Label-MS Homo sapiens
481 UPF3B 65109
Proximity Label-MS Homo sapiens
482 ANK3  
Proximity Label-MS Homo sapiens
483 PPFIA1 8500
Proximity Label-MS Homo sapiens
484 BAIAP2 10458
Proximity Label-MS Homo sapiens
485 SH3KBP1 30011
Affinity Capture-Western Homo sapiens
486 DDX49 54555
Proximity Label-MS Homo sapiens
487 FARP1 10160
Proximity Label-MS Homo sapiens
488 KIAA1522 57648
Proximity Label-MS Homo sapiens
489 PPP1R15A  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
490 TNK2 10188
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
491 KIAA1804  
Proximity Label-MS Homo sapiens
492 SPTAN1 6709
Proximity Label-MS Homo sapiens
493 SHISA2 387914
Proximity Label-MS Homo sapiens
494 MPP6 51678
Proximity Label-MS Homo sapiens
495 BKRF1  
Affinity Capture-MS
496 ROCK1 6093
Proximity Label-MS Homo sapiens
497 Osgep  
Affinity Capture-MS Mus musculus
498 INPPL1 3636
Proximity Label-MS Homo sapiens
499 IL1R1 3554
Affinity Capture-Western Homo sapiens
500 PLCB1 23236
Proximity Label-MS Homo sapiens
501 UBA52 7311
Proximity Label-MS Homo sapiens
502 ABCC5 10057
Proximity Label-MS Homo sapiens
503 TRAT1 50852
Reconstituted Complex Homo sapiens
504 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
505 NISCH 11188
Proximity Label-MS Homo sapiens
506 EPB41L2 2037
Proximity Label-MS Homo sapiens
507 ADAM15 8751
Reconstituted Complex Homo sapiens
508 ROR2 4920
Proximity Label-MS Homo sapiens
509 CD36 948
Affinity Capture-Western Homo sapiens
510 ZDHHC8 29801
Proximity Label-MS Homo sapiens
511 DOK1 1796
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
512 MICAL3 57553
Proximity Label-MS Homo sapiens
513 SLC38A1 81539
Proximity Label-MS Homo sapiens
514 SLC6A8 6535
Proximity Label-MS Homo sapiens
515 RPS6 6194
Proximity Label-MS Homo sapiens
516 PIK3R2 5296
Proximity Label-MS Homo sapiens
517 GP6 51206
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
518 ESYT1 23344
Proximity Label-MS Homo sapiens
519 CDK16 5127
Proximity Label-MS Homo sapiens
520 DSG2 1829
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LYN is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
Anti-inflammatory response favouring Leishmania parasite infection TAS Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IEA Reactome
Axon guidance TAS Reactome
Axon guidance IEA Reactome
C-type lectin receptors (CLRs) TAS Reactome
CD209 (DC-SIGN) signaling TAS Reactome
CD22 mediated BCR regulation TAS Reactome
CD28 co-stimulation TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cell surface interactions at the vascular wall TAS Reactome
Costimulation by the CD28 family TAS Reactome
CTLA4 inhibitory signaling TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cytokine Signaling in Immune system IEA Reactome
Cytokine Signaling in Immune system TAS Reactome
Dectin-2 family TAS Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
EPH-ephrin mediated repulsion of cells TAS Reactome
EPH-Ephrin signaling TAS Reactome
EPH-Ephrin signaling IEA Reactome
EPHA-mediated growth cone collapse TAS Reactome
EPHA-mediated growth cone collapse IEA Reactome
EPHB-mediated forward signaling TAS Reactome
EPHB-mediated forward signaling IEA Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) TAS Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) IEA Reactome
Erythropoietin activates Phospholipase C gamma (PLCG) IEA Reactome
Erythropoietin activates RAS IEA Reactome
Erythropoietin activates RAS TAS Reactome
Erythropoietin activates STAT5 IEA Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
Fc epsilon receptor (FCERI) signaling IEA Reactome
FCERI mediated Ca+2 mobilization IEA Reactome
FCERI mediated Ca+2 mobilization TAS Reactome
FCERI mediated MAPK activation TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
Fcgamma receptor (FCGR) dependent phagocytosis TAS Reactome
FCGR activation TAS Reactome
FCGR3A-mediated IL10 synthesis TAS Reactome
FCGR3A-mediated phagocytosis TAS Reactome
G1 Phase TAS Reactome
GPVI-mediated activation cascade TAS Reactome
Growth hormone receptor signaling IEA Reactome
Growth hormone receptor signaling TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Inactivation of CSF3 (G-CSF) signaling IEA Reactome
Inactivation of CSF3 (G-CSF) signaling TAS Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling IEA Reactome
Interleukin-3, Interleukin-5 and GM-CSF signaling TAS Reactome
Leishmania infection TAS Reactome
Leishmania parasite growth and survival TAS Reactome
Leishmania phagocytosis TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
Nervous system development TAS Reactome
Nervous system development IEA Reactome
Parasite infection TAS Reactome
Parasitic Infection Pathways TAS Reactome
PECAM1 interactions TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Adhesion to exposed collagen TAS Reactome
Regulation of KIT signaling TAS Reactome
Regulation of signaling by CBL IEA Reactome
Regulation of signaling by CBL TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization TAS Reactome
Role of LAT2/NTAL/LAB on calcium mobilization IEA Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by CSF1 (M-CSF) in myeloid cells IEA Reactome
Signaling by CSF3 (G-CSF) IEA Reactome
Signaling by CSF3 (G-CSF) TAS Reactome
Signaling by Erythropoietin IEA Reactome
Signaling by Erythropoietin TAS Reactome
Signaling by Interleukins IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by KIT in disease TAS Reactome
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Signaling by SCF-KIT TAS Reactome
Signaling by SCF-KIT IEA Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome





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