Gene description for DEPDC1B
Gene name DEP domain containing 1B
Gene symbol DEPDC1B
Other names/aliases BRCC3
XTP1
Species Homo sapiens
 Database cross references - DEPDC1B
ExoCarta ExoCarta_55789
Vesiclepedia VP_55789
Entrez Gene 55789
HGNC 24902
MIM 616073
UniProt Q8WUY9  
 DEPDC1B identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for DEPDC1B
Molecular Function
    GTPase activator activity GO:0005096 IEA
Biological Process
    cell migration GO:0016477 IMP
    positive regulation of Wnt signaling pathway GO:0030177 IBA
    positive regulation of Wnt signaling pathway GO:0030177 IMP
    intracellular signal transduction GO:0035556 IEA
 Experiment description of studies that identified DEPDC1B in exosomes
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DEPDC1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
2 GJD3  
Proximity Label-MS Homo sapiens
3 MTCH1 23787
Proximity Label-MS Homo sapiens
4 OCLN 100506658
Proximity Label-MS Homo sapiens
5 KSR1  
Affinity Capture-MS Homo sapiens
6 ADCK3  
Affinity Capture-MS Homo sapiens
7 MARCKS 4082
Proximity Label-MS Homo sapiens
8 LAMP3  
Proximity Label-MS Homo sapiens
9 GJA1 2697
Proximity Label-MS Homo sapiens
10 PKP2 5318
Affinity Capture-MS Homo sapiens
11 DYNC1I2 1781
Proximity Label-MS Homo sapiens
12 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CA2 760
Affinity Capture-MS Homo sapiens
14 BSCL2  
Affinity Capture-MS Homo sapiens
15 NUP153 9972
Affinity Capture-MS Homo sapiens
16 CDC25B 994
Affinity Capture-MS Homo sapiens
17 HSD17B11 51170
Proximity Label-MS Homo sapiens
18 SRGAP2 23380
Affinity Capture-MS Homo sapiens
19 LAMP2 3920
Proximity Label-MS Homo sapiens
20 CAND1 55832
Affinity Capture-MS Homo sapiens
21 CBY1  
Affinity Capture-MS Homo sapiens
22 COPA 1314
Affinity Capture-MS Homo sapiens
23 EIF4E2  
Affinity Capture-MS Homo sapiens
24 KIF13B 23303
Affinity Capture-MS Homo sapiens
25 UHMK1  
Two-hybrid Homo sapiens
26 RUVBL1 8607
Affinity Capture-MS Homo sapiens
27 B3GAT1  
Proximity Label-MS Homo sapiens
28 RDX 5962
Proximity Label-MS Homo sapiens
29 MLLT4 4301
Proximity Label-MS Homo sapiens
30 ZBTB21  
Affinity Capture-MS Homo sapiens
31 ZNF638 27332
Affinity Capture-MS Homo sapiens
32 RAB3IP  
Affinity Capture-MS Homo sapiens
33 RAB3B 5865
Proximity Label-MS Homo sapiens
34 MDC1  
Affinity Capture-MS Homo sapiens
35 ABCD3 5825
Affinity Capture-MS Homo sapiens
36 NUP93 9688
Affinity Capture-MS Homo sapiens
37 YWHAG 7532
Affinity Capture-MS Homo sapiens
38 CHCHD3 54927
Affinity Capture-MS Homo sapiens
39 MCM6 4175
Affinity Capture-MS Homo sapiens
40 ACRBP  
Affinity Capture-MS Homo sapiens
41 DCLK1 9201
Affinity Capture-MS Homo sapiens
42 DGCR2 9993
Affinity Capture-MS Homo sapiens
43 LRFN1  
Affinity Capture-MS Homo sapiens
44 RAB35 11021
Proximity Label-MS Homo sapiens
45 EBAG9 9166
Proximity Label-MS Homo sapiens
46 LAMTOR1 55004
Proximity Label-MS Homo sapiens
47 SMC4 10051
Affinity Capture-MS Homo sapiens
48 LMAN1 3998
Proximity Label-MS Homo sapiens
49 AGAP1  
Affinity Capture-MS Homo sapiens
50 XPO1 7514
Affinity Capture-MS Homo sapiens
51 PRPF6 24148
Affinity Capture-MS Homo sapiens
52 CDK16 5127
Affinity Capture-MS Homo sapiens
53 SNRNP70 6625
Affinity Capture-MS Homo sapiens
54 UBE2T  
Affinity Capture-Western Homo sapiens
55 CDC23 8697
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
56 ANKRD34A  
Affinity Capture-MS Homo sapiens
57 USP21  
Affinity Capture-MS Homo sapiens
58 PARK2  
Affinity Capture-MS Homo sapiens
59 CXADR 1525
Proximity Label-MS Homo sapiens
60 FAM110A  
Affinity Capture-MS Homo sapiens
61 SIPA1L1 26037
Affinity Capture-MS Homo sapiens
62 COPG1 22820
Affinity Capture-MS Homo sapiens
63 TESK2  
Affinity Capture-MS Homo sapiens
64 LYN 4067
Proximity Label-MS Homo sapiens
65 MCAM 4162
Proximity Label-MS Homo sapiens
66 RAB4A 5867
Proximity Label-MS Homo sapiens
67 DNAJC5 80331
Proximity Label-MS Homo sapiens
68 SMARCA4 6597
Affinity Capture-MS Homo sapiens
69 RGS3 5998
Two-hybrid Homo sapiens
70 PARD3 56288
Proximity Label-MS Homo sapiens
71 DIRAS3  
Proximity Label-MS Homo sapiens
72 BACE2 25825
Affinity Capture-MS Homo sapiens
73 SLC25A22  
Affinity Capture-MS Homo sapiens
74 ARRDC3 57561
Affinity Capture-MS Homo sapiens
75 ANAPC4 29945
Affinity Capture-MS Homo sapiens
76 ARHGEF12 23365
Affinity Capture-MS Homo sapiens
77 FAM110B  
Affinity Capture-MS Homo sapiens
78 KCTD3  
Affinity Capture-MS Homo sapiens
79 ELOVL5 60481
Proximity Label-MS Homo sapiens
80 ZNF326 284695
Affinity Capture-MS Homo sapiens
81 PHLPP1  
Proximity Label-MS Homo sapiens
82 LIMA1 51474
Affinity Capture-MS Homo sapiens
83 NUMA1 4926
Affinity Capture-MS Homo sapiens
84 PRPF4B 8899
Affinity Capture-MS Homo sapiens
85 RPN2 6185
Proximity Label-MS Homo sapiens
86 ZFR 51663
Affinity Capture-MS Homo sapiens
87 RAB5A 5868
Proximity Label-MS Homo sapiens
88 PANX1 24145
Proximity Label-MS Homo sapiens
89 SMARCA5 8467
Affinity Capture-MS Homo sapiens
90 LAMP1 3916
Proximity Label-MS Homo sapiens
91 IFI30  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 LMNB2 84823
Affinity Capture-MS Homo sapiens
93 CDC16 8881
Affinity Capture-MS Homo sapiens
94 EPPK1 83481
Affinity Capture-MS Homo sapiens
95 HSD3B7 80270
Proximity Label-MS Homo sapiens
96 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 CSE1L 1434
Affinity Capture-MS Homo sapiens
98 ARF6 382
Proximity Label-MS Homo sapiens
99 SYDE1 85360
Affinity Capture-MS Homo sapiens
100 PRKACA 5566
Proximity Label-MS Homo sapiens
101 DKC1 1736
Affinity Capture-MS Homo sapiens
102 NEFL 4747
Affinity Capture-MS Homo sapiens
103 ATP2A1 487
Proximity Label-MS Homo sapiens
104 GIGYF1  
Affinity Capture-MS Homo sapiens
105 RAB9A 9367
Proximity Label-MS Homo sapiens
106 HP1BP3 50809
Affinity Capture-MS Homo sapiens
107 COPB2 9276
Affinity Capture-MS Homo sapiens
108 MOB2 81532
Affinity Capture-MS Homo sapiens
109 RHOB 388
Proximity Label-MS Homo sapiens
110 ADAR 103
Affinity Capture-MS Homo sapiens
111 GRIP1  
Two-hybrid Homo sapiens
112 AKAP1 8165
Proximity Label-MS Homo sapiens
113 HUWE1 10075
Affinity Capture-MS Homo sapiens
114 BIRC5  
Affinity Capture-Western Homo sapiens
115 GSN 2934
Affinity Capture-MS Homo sapiens
116 NES 10763
Affinity Capture-MS Homo sapiens
117 LBR 3930
Affinity Capture-MS Homo sapiens
118 DDX50 79009
Affinity Capture-MS Homo sapiens
119 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
120 ANKFY1 51479
Proximity Label-MS Homo sapiens
121 FAM53C 51307
Affinity Capture-MS Homo sapiens
122 PLEC 5339
Affinity Capture-MS Homo sapiens
123 RTKN 6242
Affinity Capture-MS Homo sapiens
124 DENND1A 57706
Affinity Capture-MS Homo sapiens
125 PPM1H  
Affinity Capture-MS Homo sapiens
126 LONP1 9361
Affinity Capture-MS Homo sapiens
127 ERLIN1 10613
Affinity Capture-MS Homo sapiens
128 EZR 7430
Proximity Label-MS Homo sapiens
129 SRSF12  
Affinity Capture-MS Homo sapiens
130 NGEF  
Affinity Capture-MS Homo sapiens
131 SEPT10 151011
Proximity Label-MS Homo sapiens
132 ANAPC1 64682
Affinity Capture-MS Homo sapiens
133 COX8A  
Proximity Label-MS Homo sapiens
134 RBM15 64783
Affinity Capture-MS Homo sapiens
135 ERGIC1 57222
Proximity Label-MS Homo sapiens
136 C11orf52 91894
Proximity Label-MS Homo sapiens
137 SFXN1 94081
Affinity Capture-MS Homo sapiens
138 MRPS18B 28973
Affinity Capture-MS Homo sapiens
139 RAB2A 5862
Proximity Label-MS Homo sapiens
140 DNAJC5B  
Proximity Label-MS Homo sapiens
141 EBPL 84650
Two-hybrid Homo sapiens
142 RAB11A 8766
Proximity Label-MS Homo sapiens
143 PYCR1 5831
Affinity Capture-MS Homo sapiens
144 EPHA2 1969
Proximity Label-MS Homo sapiens
145 KRAS 3845
Proximity Label-MS Homo sapiens
146 RAB5C 5878
Proximity Label-MS Homo sapiens
147 MAST3  
Affinity Capture-MS Homo sapiens
148 MAGI1  
Affinity Capture-MS Homo sapiens
149 CAV1 857
Proximity Label-MS Homo sapiens
150 RANGAP1 5905
Affinity Capture-MS Homo sapiens
151 RPRD1A  
Affinity Capture-MS Homo sapiens
152 PSMD3 5709
Affinity Capture-MS Homo sapiens
153 SH3PXD2A 9644
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here