Gene description for PKP2
Gene name plakophilin 2
Gene symbol PKP2
Other names/aliases ARVD9
Species Homo sapiens
 Database cross references - PKP2
ExoCarta ExoCarta_5318
Vesiclepedia VP_5318
Entrez Gene 5318
HGNC 9024
MIM 602861
UniProt Q99959  
 PKP2 identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for PKP2
Molecular Function
    DNA binding GO:0003677 IDA
    protein kinase C binding GO:0005080 IPI
    protein binding GO:0005515 IPI
    sodium channel regulator activity GO:0017080 ISS
    intermediate filament binding GO:0019215 IDA
    transmembrane transporter binding GO:0044325 ISS
    alpha-catenin binding GO:0045294 IPI
    cadherin binding GO:0045296 HDA
    cadherin binding GO:0045296 IBA
    molecular adaptor activity GO:0060090 IMP
    cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 IC
Biological Process
    desmosome assembly GO:0002159 IMP
    desmosome organization GO:0002934 IBA
    cell-cell signaling GO:0007267 IMP
    heart development GO:0007507 IBA
    heart development GO:0007507 ISS
    positive regulation of sodium ion transport GO:0010765 ISS
    regulation of cell-substrate adhesion GO:0010810 IMP
    intermediate filament bundle assembly GO:0045110 IBA
    intermediate filament bundle assembly GO:0045110 IMP
    maintenance of animal organ identity GO:0048496 IMP
    ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP
    protein localization to plasma membrane GO:0072659 IBA
    protein localization to plasma membrane GO:0072659 IMP
    cardiac muscle cell action potential involved in contraction GO:0086002 IMP
    ventricular cardiac muscle cell action potential GO:0086005 IMP
    cell communication by electrical coupling involved in cardiac conduction GO:0086064 ISS
    bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 IMP
    regulation of heart rate by cardiac conduction GO:0086091 IMP
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 ISS
    cell-cell adhesion GO:0098609 NAS
    regulation of ventricular cardiac muscle cell action potential GO:0098911 IMP
    maintenance of protein localization at cell tip GO:0099017 ISS
    regulation of substrate adhesion-dependent cell spreading GO:1900024 IMP
Subcellular Localization
    cornified envelope GO:0001533 TAS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    intermediate filament GO:0005882 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IDA
    cell-cell junction GO:0005911 ISS
    adherens junction GO:0005912 IBA
    intercalated disc GO:0014704 IBA
    intercalated disc GO:0014704 IDA
    intercalated disc GO:0014704 ISS
    membrane GO:0016020 TAS
    cell junction GO:0030054 IDA
    desmosome GO:0030057 IDA
    desmosome GO:0030057 ISS
    desmosome GO:0030057 NAS
    cell tip GO:0051286 IEA
 Experiment description of studies that identified PKP2 in sEVs
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PKP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 PCED1A  
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 ECT2L  
Affinity Capture-MS Homo sapiens
6 RBPMS 11030
Two-hybrid Homo sapiens
7 OCLN 100506658
Proximity Label-MS Homo sapiens
8 TRNAU1AP  
Affinity Capture-MS Homo sapiens
9 FGD2 221472
Affinity Capture-MS Homo sapiens
10 LAMP3  
Proximity Label-MS Homo sapiens
11 GJA1 2697
Proximity Label-MS Homo sapiens
12 FOXF2  
Affinity Capture-MS Homo sapiens
13 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TRIM66  
Affinity Capture-MS Homo sapiens
16 APC  
Affinity Capture-MS Homo sapiens
17 KIF20A 10112
Affinity Capture-MS Homo sapiens
18 LAMP2 3920
Proximity Label-MS Homo sapiens
19 VHL  
Two-hybrid Homo sapiens
20 TAF1  
Affinity Capture-MS Homo sapiens
21 HERC2P9  
Affinity Capture-MS Homo sapiens
22 CAPZB 832
Affinity Capture-MS Homo sapiens
23 DROSHA  
Affinity Capture-MS Homo sapiens
24 MLLT4 4301
Proximity Label-MS Homo sapiens
25 KIF23 9493
Affinity Capture-MS Homo sapiens
26 FBLIM1 54751
Affinity Capture-MS Homo sapiens
27 ACTR3 10096
Proximity Label-MS Homo sapiens
28 SIRT6  
Affinity Capture-MS Homo sapiens
29 PRC1 9055
Affinity Capture-MS Homo sapiens
30 DSC2 1824
Two-hybrid Homo sapiens
31 GPRC5B 51704
Affinity Capture-MS Homo sapiens
32 TNFRSF19  
Affinity Capture-MS Homo sapiens
33 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 MTUS2 23281
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
35 KRT5 3852
Reconstituted Complex Homo sapiens
36 KRT31 3881
Two-hybrid Homo sapiens
37 MKI67  
Affinity Capture-MS Homo sapiens
38 RHOB 388
Proximity Label-MS Homo sapiens
39 EED  
Affinity Capture-MS Homo sapiens
40 YWHAH 7533
Affinity Capture-MS Homo sapiens
41 SFN 2810
Affinity Capture-MS Homo sapiens
42 GTSE1 51512
Affinity Capture-MS Homo sapiens
43 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 RAB35 11021
Proximity Label-MS Homo sapiens
45 KCTD13 253980
Affinity Capture-MS Homo sapiens
46 CTBP1 1487
Two-hybrid Homo sapiens
47 MARCKS 4082
Proximity Label-MS Homo sapiens
48 KIF14 9928
Affinity Capture-MS Homo sapiens
49 KCNE3  
Affinity Capture-MS Homo sapiens
50 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CLK2 1196
Affinity Capture-MS Homo sapiens
52 FOXA1  
Affinity Capture-MS Homo sapiens
53 DSG1 1828
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
54 FHL3 2275
Affinity Capture-MS Homo sapiens
55 PGAM5 192111
Co-fractionation Homo sapiens
56 PDGFRB 5159
Affinity Capture-MS Homo sapiens
57 CXADR 1525
Proximity Label-MS Homo sapiens
58 ARMC8 25852
Two-hybrid Homo sapiens
59 RBM4B  
Affinity Capture-MS Homo sapiens
60 KLC4 89953
Two-hybrid Homo sapiens
61 LYN 4067
Proximity Label-MS Homo sapiens
62 Sec24c  
Affinity Capture-MS Mus musculus
63 PRPS2 5634
Affinity Capture-MS Homo sapiens
64 ESRRB  
Affinity Capture-MS Homo sapiens
65 CDH1 999
Proximity Label-MS Homo sapiens
66 CHMP4B 128866
Affinity Capture-MS Homo sapiens
67 PARD3 56288
Proximity Label-MS Homo sapiens
68 DIRAS3  
Proximity Label-MS Homo sapiens
69 WDYHV1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 AKAP9 10142
Two-hybrid Homo sapiens
71 EPB41L4A 64097
Proximity Label-MS Homo sapiens
72 CECR2  
Affinity Capture-MS Homo sapiens
73 CTNNB1 1499
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
74 CLEC11A 6320
Affinity Capture-MS Homo sapiens
75 YWHAQ 10971
Affinity Capture-Western Homo sapiens
76 PML 5371
Affinity Capture-MS Homo sapiens
77 HSPB8 26353
Affinity Capture-MS Homo sapiens
78 CACNG4  
Affinity Capture-MS Homo sapiens
79 SP100 6672
Affinity Capture-MS Homo sapiens
80 SCARNA22  
Affinity Capture-RNA Homo sapiens
81 ANLN 54443
Affinity Capture-MS Homo sapiens
82 TMEM52B 120939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 RBM5  
Two-hybrid Homo sapiens
84 PCDHGB1  
Affinity Capture-MS Homo sapiens
85 POLR3A 11128
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
86 KRT18 3875
Reconstituted Complex Homo sapiens
87 KIR2DL1  
Affinity Capture-MS Homo sapiens
88 C9orf78 51759
Affinity Capture-MS Homo sapiens
89 RC3H2  
Affinity Capture-MS Homo sapiens
90 ECT2 1894
Affinity Capture-MS Homo sapiens
91 SLC14A2  
Affinity Capture-MS Homo sapiens
92 LAMP1 3916
Proximity Label-MS Homo sapiens
93 BRD8 10902
Affinity Capture-MS Homo sapiens
94 PHIP 55023
Affinity Capture-MS Homo sapiens
95 CUL3 8452
Affinity Capture-MS Homo sapiens
96 YWHAZ 7534
Affinity Capture-MS Homo sapiens
97 BTF3 689
Affinity Capture-MS Homo sapiens
98 LRRC4C  
Affinity Capture-MS Homo sapiens
99 ARF6 382
Proximity Label-MS Homo sapiens
100 PNMA2  
Affinity Capture-MS Homo sapiens
101 CEP250 11190
Affinity Capture-MS Homo sapiens
102 MYO6 4646
Proximity Label-MS Homo sapiens
103 Uso1 56041
Affinity Capture-MS Mus musculus
104 SMAD9  
Two-hybrid Homo sapiens
105 SEC16A 9919
Affinity Capture-MS Homo sapiens
106 RAB9A 9367
Proximity Label-MS Homo sapiens
107 TACR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 MATR3 9782
Affinity Capture-MS Homo sapiens
109 RNF2  
Affinity Capture-MS Homo sapiens
110 BMI1  
Affinity Capture-MS Homo sapiens
111 ILK 3611
Affinity Capture-MS Homo sapiens
112 CTNNA1 1495
Proximity Label-MS Homo sapiens
113 FAM188A 80013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 PEX3 8504
Proximity Label-MS Homo sapiens
116 AKAP1 8165
Proximity Label-MS Homo sapiens
117 FLOT1 10211
Proximity Label-MS Homo sapiens
118 BAG4  
Two-hybrid Homo sapiens
119 DSP 1832
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
120 MARK3 4140
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
121 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
122 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
123 GRN 2896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 NAAA  
Affinity Capture-MS Homo sapiens
125 HSPB2  
Two-hybrid Homo sapiens
126 LAMTOR1 55004
Proximity Label-MS Homo sapiens
127 JUP 3728
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
128 VIM 7431
Two-hybrid Homo sapiens
129 HAVCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 DMRTB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
131 LCK 3932
Proximity Label-MS Homo sapiens
132 CASK 8573
Two-hybrid Homo sapiens
133 DSC1 1823
Two-hybrid Homo sapiens
134 EIF4ENIF1 56478
Two-hybrid Homo sapiens
135 KLHL40  
Affinity Capture-MS Homo sapiens
136 C11orf52 91894
Proximity Label-MS Homo sapiens
137 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 GTF2B 2959
Affinity Capture-Western Homo sapiens
139 LMAN1 3998
Proximity Label-MS Homo sapiens
140 Dynlt1b  
Two-hybrid Mus musculus
141 RAB2A 5862
Proximity Label-MS Homo sapiens
142 EYA4 2070
Affinity Capture-MS Homo sapiens
143 CEP135  
Proximity Label-MS Homo sapiens
144 PINK1  
Affinity Capture-MS Homo sapiens
145 RAB11A 8766
Proximity Label-MS Homo sapiens
146 CIT 11113
Affinity Capture-MS Homo sapiens
147 NDEL1 81565
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
148 KIR2DL4  
Affinity Capture-MS Homo sapiens
149 KRAS 3845
Proximity Label-MS Homo sapiens
150 MAST3  
Affinity Capture-MS Homo sapiens
151 PCDHGA7 56108
Affinity Capture-MS Homo sapiens
152 RPA2 6118
Proximity Label-MS Homo sapiens
153 RPA3 6119
Proximity Label-MS Homo sapiens
154 CAV1 857
Proximity Label-MS Homo sapiens
155 EXOSC8  
Two-hybrid Homo sapiens
156 DSG2 1829
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PKP2 is involved
PathwayEvidenceSource
Developmental Biology TAS Reactome
Formation of the cornified envelope TAS Reactome
Keratinization TAS Reactome





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