Gene description for GTSE1
Gene name G-2 and S-phase expressed 1
Gene symbol GTSE1
Other names/aliases B99
Species Homo sapiens
 Database cross references - GTSE1
ExoCarta ExoCarta_51512
Vesiclepedia VP_51512
Entrez Gene 51512
HGNC 13698
MIM 607477
UniProt Q9NYZ3  
 GTSE1 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 25844599    
 Gene ontology annotations for GTSE1
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
Biological Process
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 NAS
    microtubule-based process GO:0007017 NAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 TAS
    cytoplasmic microtubule GO:0005881 IBA
    cytoplasmic microtubule GO:0005881 IDA
    microtubule cytoskeleton GO:0015630 IBA
    membrane GO:0016020 HDA
 Experiment description of studies that identified GTSE1 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for GTSE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MVP 9961
Affinity Capture-MS Homo sapiens
2 CRTC2 200186
Affinity Capture-MS Homo sapiens
3 AP2B1 163
Affinity Capture-MS Homo sapiens
4 PER1  
Affinity Capture-MS Homo sapiens
5 VTI1B 10490
Affinity Capture-MS Homo sapiens
6 RAB1A 5861
Affinity Capture-MS Homo sapiens
7 AAK1 22848
Affinity Capture-MS Homo sapiens
8 WNK1 65125
Affinity Capture-MS Homo sapiens
9 PKP2 5318
Affinity Capture-MS Homo sapiens
10 KAT5  
Two-hybrid Homo sapiens
11 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
12 P4HA2 8974
Affinity Capture-MS Homo sapiens
13 GAK 2580
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 LIMA1 51474
Affinity Capture-MS Homo sapiens
15 EPS15 2060
Affinity Capture-MS Homo sapiens
16 FAM21A 387680
Affinity Capture-MS Homo sapiens
17 VHL  
Negative Genetic Homo sapiens
18 CAMSAP2  
Proximity Label-MS Homo sapiens
19 Actb 11461
Affinity Capture-MS Mus musculus
20 CLTB 1212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 FCHO2 115548
Affinity Capture-MS Homo sapiens
22 FAM109B  
Affinity Capture-MS Homo sapiens
23 WTAP 9589
Two-hybrid Homo sapiens
24 CDC16 8881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TNK1  
Affinity Capture-MS Homo sapiens
26 TNRC6A 27327
Affinity Capture-MS Homo sapiens
27 USO1 8615
Affinity Capture-MS Homo sapiens
28 TRNAU1AP  
Two-hybrid Homo sapiens
29 AP2A1 160
Affinity Capture-MS Homo sapiens
30 DNMBP 23268
Affinity Capture-MS Homo sapiens
31 WDR83  
Two-hybrid Homo sapiens
32 IQGAP1 8826
Affinity Capture-MS Homo sapiens
33 SEC24C 9632
Affinity Capture-MS Homo sapiens
34 FAM83H 286077
Affinity Capture-MS Homo sapiens
35 AP1G1 164
Affinity Capture-MS Homo sapiens
36 CPSF7 79869
Two-hybrid Homo sapiens
37 STON2 85439
Affinity Capture-MS Homo sapiens
38 BOD1L1 259282
Affinity Capture-MS Homo sapiens
39 HERC2 8924
Affinity Capture-MS Homo sapiens
40 TULP3 7289
Affinity Capture-MS Homo sapiens
41 IL17RA 23765
Affinity Capture-MS Homo sapiens
42 SEC23A 10484
Affinity Capture-MS Homo sapiens
43 KPTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SNX9 51429
Affinity Capture-MS Homo sapiens
45 Sec24c  
Affinity Capture-MS Mus musculus
46 THOC1 9984
Affinity Capture-MS Homo sapiens
47 TNFRSF1B  
Affinity Capture-MS Homo sapiens
48 RBM14 10432
Affinity Capture-MS Homo sapiens
49 SCYL2 55681
Affinity Capture-MS Homo sapiens
50 STAMBPL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 CASK 8573
Two-hybrid Homo sapiens
52 CAV3 859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 EDC4 23644
Affinity Capture-MS Homo sapiens
54 CAMK2A 815
Affinity Capture-MS Homo sapiens
55 PPIE 10450
Two-hybrid Homo sapiens
56 USP11 8237
Affinity Capture-MS Homo sapiens
57 SDCCAG3  
Affinity Capture-MS Homo sapiens
58 NBR1 4077
Affinity Capture-MS Homo sapiens
59 MAPRE1 22919
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
60 CLTCL1 8218
Affinity Capture-MS Homo sapiens
61 GOLGA2 2801
Affinity Capture-MS Homo sapiens
62 Mapre3  
Two-hybrid Mus musculus
63 TRIM37  
Proximity Label-MS Homo sapiens
64 CARM1 10498
Affinity Capture-MS Homo sapiens
65 NUMB 8650
Affinity Capture-MS Homo sapiens
66 MYH9 4627
Affinity Capture-MS Homo sapiens
67 BARD1 580
Affinity Capture-MS Homo sapiens
68 SYNJ1 8867
Affinity Capture-MS Homo sapiens
69 BTBD3  
Affinity Capture-MS Homo sapiens
70 DCAF7 10238
Affinity Capture-MS Homo sapiens
71 PNMA2  
Affinity Capture-MS Homo sapiens
72 AP1B1 162
Affinity Capture-MS Homo sapiens
73 BMP2K 55589
Affinity Capture-MS Homo sapiens
74 CSNK1E 1454
Affinity Capture-MS Homo sapiens
75 APBA1  
Affinity Capture-MS Homo sapiens
76 FBLN5 10516
Affinity Capture-MS Homo sapiens
77 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
78 NINL  
Proximity Label-MS Homo sapiens
79 STAMBP 10617
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 NECAP1 25977
Affinity Capture-MS Homo sapiens
81 PICALM 8301
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 MTMR4  
Affinity Capture-MS Homo sapiens
83 DBN1 1627
Affinity Capture-MS Homo sapiens
84 DNAJB11 51726
Affinity Capture-MS Homo sapiens
85 PIPSL 266971
Affinity Capture-MS Homo sapiens
86 PRPF39 55015
Two-hybrid Homo sapiens
87 RBM10  
Two-hybrid Homo sapiens
88 Mapre2 212307
Two-hybrid Mus musculus
89 ANLN 54443
Affinity Capture-MS Homo sapiens
90 PHLPP1  
Proximity Label-MS Homo sapiens
91 PPP2R3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 HNRNPD 3184
Two-hybrid Homo sapiens
93 FAM83B  
Affinity Capture-MS Homo sapiens
94 CLINT1 9685
Affinity Capture-MS Homo sapiens
95 XPO1 7514
Affinity Capture-MS Homo sapiens
96 NDUFA9 4704
Affinity Capture-MS Homo sapiens
97 SEC13 6396
Affinity Capture-MS Homo sapiens
98 OCRL 4952
Affinity Capture-MS Homo sapiens
99 NCAPH2  
Affinity Capture-MS Homo sapiens
100 ERBB2IP 55914
Affinity Capture-MS Homo sapiens
101 AKAP9 10142
Two-hybrid Homo sapiens
102 CTTN 2017
Two-hybrid Homo sapiens
103 MEX3A  
Affinity Capture-RNA Homo sapiens
104 GAST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 AP1M1 8907
Affinity Capture-MS Homo sapiens
106 MYPN 84665
Affinity Capture-MS Homo sapiens
107 DDB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 MYO19  
Affinity Capture-MS Homo sapiens
109 TMEM74  
Affinity Capture-MS Homo sapiens
110 HIP1R 9026
Affinity Capture-MS Homo sapiens
111 RCN1 5954
Affinity Capture-MS Homo sapiens
112 DCTN1 1639
Proximity Label-MS Homo sapiens
113 KIAA0430  
Affinity Capture-MS Homo sapiens
114 AP2M1 1173
Affinity Capture-MS Homo sapiens
115 LZTS2 84445
Affinity Capture-MS Homo sapiens
116 MAPRE3  
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
117 KCNE3  
Affinity Capture-MS Homo sapiens
118 MYO6 4646
Affinity Capture-MS Homo sapiens
119 Uso1 56041
Affinity Capture-MS Mus musculus
120 FXR2 9513
Two-hybrid Homo sapiens
121 PKP4 8502
Affinity Capture-MS Homo sapiens
122 SEC16A 9919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 EPN1 29924
Affinity Capture-MS Homo sapiens
124 AP2A2 161
Affinity Capture-MS Homo sapiens
125 SMAP2 64744
Affinity Capture-MS Homo sapiens
126 PHF5A 84844
Two-hybrid Homo sapiens
127 N4BP3  
Affinity Capture-MS Homo sapiens
128 HIP1 3092
Affinity Capture-MS Homo sapiens
129 BCAR3 8412
Affinity Capture-MS Homo sapiens
130 CLTC 1213
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 KBTBD7  
Affinity Capture-MS Homo sapiens
132 NUMBL 9253
Affinity Capture-MS Homo sapiens
133 TNRC6B  
Affinity Capture-MS Homo sapiens
134 AP1S1 1174
Affinity Capture-MS Homo sapiens
135 CCDC8  
Affinity Capture-MS Homo sapiens
136 PHGDH 26227
Affinity Capture-MS Homo sapiens
137 PKP3 11187
Affinity Capture-MS Homo sapiens
138 SYNRG 11276
Affinity Capture-MS Homo sapiens
139 SEC24B 10427
Affinity Capture-MS Homo sapiens
140 FTL 2512
Affinity Capture-MS Homo sapiens
141 RALBP1 10928
Affinity Capture-MS Homo sapiens
142 TNK2 10188
Affinity Capture-MS Homo sapiens
143 KIF2A 3796
Proximity Label-MS Homo sapiens
144 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
145 SEC24A 10802
Affinity Capture-MS Homo sapiens
146 DAB2 1601
Affinity Capture-MS Homo sapiens
147 CDC42 998
Affinity Capture-MS Homo sapiens
148 MTMR3  
Affinity Capture-MS Homo sapiens
149 DENND1A 57706
Affinity Capture-MS Homo sapiens
150 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
151 FOXJ2  
Affinity Capture-MS Homo sapiens
152 CALU 813
Affinity Capture-MS Homo sapiens
153 Myo1c 17913
Affinity Capture-MS Mus musculus
154 CAPZA2 830
Affinity Capture-MS Homo sapiens
155 MAPRE2 10982
Two-hybrid Homo sapiens
156 CMTR1 23070
Affinity Capture-MS Homo sapiens
157 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
158 EPN2 22905
Affinity Capture-MS Homo sapiens
159 Smap1  
Affinity Capture-MS Mus musculus
160 KIFAP3 22920
Two-hybrid Homo sapiens
161 PRKACA 5566
Affinity Capture-MS Homo sapiens
162 ACAD11 84129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 XAGE3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 C6orf141  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 C10orf88  
Affinity Capture-MS Homo sapiens
166 Eif3g 53356
Two-hybrid Mus musculus
167 KIDINS220 57498
Affinity Capture-MS Homo sapiens
168 LRPAP1 4043
Affinity Capture-MS Homo sapiens
169 Mapre1 13589
Two-hybrid Mus musculus
170 ZNF106  
Affinity Capture-MS Homo sapiens
171 REPS1 85021
Affinity Capture-MS Homo sapiens
172 RAB7A 7879
Affinity Capture-MS Homo sapiens
173 CLTA 1211
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 IGF2R 3482
Affinity Capture-MS Homo sapiens
175 PPP2R3B  
Affinity Capture-MS Homo sapiens
176 PCDHB16  
Affinity Capture-MS Homo sapiens
177 CRTC3  
Affinity Capture-MS Homo sapiens
178 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
179 CCDC96  
Affinity Capture-MS Homo sapiens
180 RPA3 6119
Proximity Label-MS Homo sapiens
181 ARX  
Affinity Capture-MS Homo sapiens
182 NIN 51199
Two-hybrid Homo sapiens
183 GNAI3 2773
Affinity Capture-MS Homo sapiens
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