Gene description for HIP1
Gene name huntingtin interacting protein 1
Gene symbol HIP1
Other names/aliases HIP-I
Species Homo sapiens
 Database cross references - HIP1
ExoCarta ExoCarta_3092
Entrez Gene 3092
HGNC 4913
MIM 601767
UniProt O00291  
 HIP1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for HIP1
Molecular Function
    clathrin binding GO:0030276 IDA
    actin binding GO:0003779 IEA
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
    phosphatidylinositol binding GO:0035091 IDA
Biological Process
    activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 IDA
    clathrin-mediated endocytosis GO:0072583 IEA
    regulation of apoptotic process GO:0042981 IDA
    apoptotic process GO:0006915 IDA
    regulation of transcription, DNA-templated GO:0006355 IEA
    apoptotic signaling pathway GO:0097190 IDA
    cell differentiation GO:0030154 IEA
    positive regulation of receptor-mediated endocytosis GO:0048260 IMP
    clathrin coat assembly GO:0048268 IDA
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    membrane GO:0016020 TAS
    Golgi apparatus GO:0005794 IDA
    clathrin-coated vesicle GO:0030136 IDA
    nucleus GO:0005634 IEA
    cytoskeleton GO:0005856 TAS
    cytoplasm GO:0005737 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    clathrin-coated vesicle membrane GO:0030665 IEA
 Experiment description of studies that identified HIP1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for HIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CASP8  
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 HTT 3064
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
4 AP2A1 160
Invivo Homo sapiens
Invitro Homo sapiens
5 CLTC 1213
Invivo Homo sapiens
Invitro Homo sapiens
6 HIP1R  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 GTF3A 2971
Invivo Homo sapiens
Invitro Homo sapiens
8 RPS10 6204
Two-hybrid Homo sapiens
9 EIF6 3692
Two-hybrid Homo sapiens
10 PFDN1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which HIP1 is involved
No pathways found

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