Gene description for SMURF1
Gene name	SMAD specific E3 ubiquitin protein ligase 1
Gene symbol	SMURF1
Other names/aliases	-
Species	Homo sapiens
Database cross references - SMURF1
ExoCarta	ExoCarta_57154
Entrez Gene	57154
HGNC	16807
MIM	605568
UniProt	Q9HCE7
SMURF1 identified in exosomes derived from the following tissue/cell type
Urine	19056867

Gene ontology annotations for SMURF1

Molecular Function     ubiquitin-protein transferase activity GO:0004842 IDA     ubiquitin protein ligase activity GO:0061630 TAS     I-SMAD binding GO:0070411 IPI     R-SMAD binding GO:0070412 IPI     activin binding GO:0048185 NAS     protein binding GO:0005515 IPI     phospholipid binding GO:0005543 TAS     ligase activity GO:0016874 IEA Biological Process     protein targeting to vacuole involved in autophagy GO:0071211 IMP     protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IDA     ubiquitin-dependent SMAD protein catabolic process GO:0030579 IDA     protein polyubiquitination GO:0000209 IDA     positive regulation of defense response to virus by host GO:0002230 IMP     negative regulation of ossification GO:0030279 IEA     negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 TAS     protein localization to cell surface GO:0034394 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     ectoderm development GO:0007398 TAS     receptor catabolic process GO:0032801 IDA     cell differentiation GO:0030154 IDA     protein ubiquitination GO:0016567 IDA     positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:2000060 IMP     positive regulation of dendrite extension GO:1903861 IDA     BMP signaling pathway GO:0030509 TAS     activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP     protein export from nucleus GO:0006611 IDA     protein targeting to plasma membrane GO:0072661 TAS     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     negative regulation of BMP signaling pathway GO:0030514 TAS Subcellular Localization     cytoplasm GO:0005737 IDA     neuronal cell body GO:0043025 IEA     extracellular exosome GO:0070062 IDA     nucleoplasm GO:0005654 TAS     mitochondrion GO:0005739 IGI     plasma membrane GO:0005886 IDA     axon GO:0030424 IEA     cytosol GO:0005829 TAS