Gene description for NOL6
Gene name nucleolar protein 6 (RNA-associated)
Gene symbol NOL6
Other names/aliases NRAP
UTP22
bA311H10.1
Species Homo sapiens
 Database cross references - NOL6
ExoCarta ExoCarta_65083
Vesiclepedia VP_65083
Entrez Gene 65083
HGNC 19910
MIM 611532
UniProt Q9H6R4  
 NOL6 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NOL6
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    rRNA processing GO:0006364 IBA
    rRNA processing GO:0006364 ISS
    tRNA export from nucleus GO:0006409 IBA
    ribosomal small subunit biogenesis GO:0042274 IDA
Subcellular Localization
    condensed nuclear chromosome GO:0000794 ISS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 ISS
    mitochondrion GO:0005739 IDA
    small-subunit processome GO:0032040 IBA
    small-subunit processome GO:0032040 IDA
    CURI complex GO:0032545 IBA
    UTP-C complex GO:0034456 IBA
 Experiment description of studies that identified NOL6 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NOL6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 RPSAP58 388524
Affinity Capture-MS Homo sapiens
5 NOP58 51602
Co-fractionation Homo sapiens
6 AATF  
Co-fractionation Homo sapiens
7 RPS4X 6191
Co-fractionation Homo sapiens
8 NOP56 10528
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
9 RPL10 6134
Affinity Capture-MS Homo sapiens
10 RPL15 6138
Affinity Capture-MS Homo sapiens
11 RSBN1  
Affinity Capture-MS Homo sapiens
12 RPS3 6188
Affinity Capture-MS Homo sapiens
13 USP36  
Affinity Capture-MS Homo sapiens
14 KIF23 9493
Affinity Capture-MS Homo sapiens
15 DDX24 57062
Co-fractionation Homo sapiens
16 MPHOSPH10 10199
Co-fractionation Homo sapiens
17 PRC1 9055
Affinity Capture-MS Homo sapiens
18 NPM1 4869
Affinity Capture-MS Homo sapiens
19 ANOS1 3730
Affinity Capture-MS Homo sapiens
20 FBL 2091
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
21 OBSL1 23363
Affinity Capture-MS Homo sapiens
22 BEND3  
Affinity Capture-MS Homo sapiens
23 EXOSC4 54512
Affinity Capture-MS Homo sapiens
24 EED  
Affinity Capture-MS Homo sapiens
25 DDX18 8886
Co-fractionation Homo sapiens
26 UTP20 27340
Co-fractionation Homo sapiens
27 MECP2 4204
Affinity Capture-MS Homo sapiens
28 MYCN  
Affinity Capture-MS Homo sapiens
29 RRP7A 27341
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 KIF14 9928
Affinity Capture-MS Homo sapiens
31 LIN28A  
Affinity Capture-MS Homo sapiens
32 NOP2 4839
Co-fractionation Homo sapiens
33 RPL4 6124
Affinity Capture-MS Homo sapiens
34 RRP9 9136
Co-fractionation Homo sapiens
35 MEX3C 51320
Affinity Capture-MS Homo sapiens
36 SRSF6 6431
Affinity Capture-MS Homo sapiens
37 ZBTB48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 UBE2I 7329
Biochemical Activity Homo sapiens
39 RPL18A 6142
Affinity Capture-MS Homo sapiens
40 Srp72  
Affinity Capture-MS Mus musculus
41 RPL31 6160
Proximity Label-MS Homo sapiens
42 RPS7 6201
Co-fractionation Homo sapiens
43 IFI16 3428
Affinity Capture-MS Homo sapiens
44 IKZF5 64376
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 RPS6 6194
Proximity Label-MS Homo sapiens
46 HECTD1 25831
Affinity Capture-MS Homo sapiens
47 ZFC3H1 196441
Affinity Capture-MS Homo sapiens
48 BRD4 23476
Affinity Capture-MS Homo sapiens
49 MAGEB2 4113
Affinity Capture-MS Homo sapiens
50 KDF1  
Affinity Capture-MS Homo sapiens
51 WDR46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 ANLN 54443
Affinity Capture-MS Homo sapiens
53 FGFBP1 9982
Affinity Capture-MS Homo sapiens
54 RRP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 FANCD2  
Affinity Capture-MS Homo sapiens
56 ABT1 29777
Affinity Capture-MS Homo sapiens
57 SORT1 6272
Affinity Capture-MS Homo sapiens
58 KIF20A 10112
Affinity Capture-MS Homo sapiens
59 ECT2 1894
Affinity Capture-MS Homo sapiens
60 SIRT7  
Affinity Capture-MS Homo sapiens
61 SURF6  
Affinity Capture-MS Homo sapiens
62 SKP2  
Affinity Capture-MS Homo sapiens
63 NR3C1 2908
Proximity Label-MS Homo sapiens
64 EGFR 1956
Affinity Capture-MS Homo sapiens
65 PDCD11 22984
Affinity Capture-MS Homo sapiens
66 SPTBN1 6711
Cross-Linking-MS (XL-MS) Homo sapiens
67 NXF1 10482
Affinity Capture-RNA Homo sapiens
68 ZNF512  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 EBNA1BP2 10969
Co-fractionation Homo sapiens
70 DGKZ  
Affinity Capture-MS Homo sapiens
71 CTCFL  
Affinity Capture-MS Homo sapiens
72 MYC  
Affinity Capture-MS Homo sapiens
73 RPA3 6119
Proximity Label-MS Homo sapiens
74 FAM64A 54478
Affinity Capture-MS Homo sapiens
75 RNF2  
Affinity Capture-MS Homo sapiens
76 BMI1  
Affinity Capture-MS Homo sapiens
77 H2AFB2  
Affinity Capture-MS Homo sapiens
78 BRD3 8019
Affinity Capture-MS Homo sapiens
79 DHX15 1665
Co-fractionation Homo sapiens
80 POP7  
Affinity Capture-MS Homo sapiens
81 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
82 PRKCSH 5589
Affinity Capture-MS Homo sapiens
83 SIRT6  
Affinity Capture-MS Homo sapiens
84 PARP1 142
Proximity Label-MS Homo sapiens
85 NOL10  
Co-fractionation Homo sapiens
86 MNDA 4332
Affinity Capture-MS Homo sapiens
87 ZNF746  
Affinity Capture-MS Homo sapiens
88 MEN1 4221
Affinity Capture-MS Homo sapiens
89 SMURF1 57154
Affinity Capture-MS Homo sapiens
90 G3BP1 10146
Affinity Capture-MS Homo sapiens
91 RPS5 6193
Co-fractionation Homo sapiens
92 NOC2L 26155
Co-fractionation Homo sapiens
93 MOV10 4343
Affinity Capture-RNA Homo sapiens
94 RPL7A 6130
Affinity Capture-MS Homo sapiens
95 Rrbp1  
Affinity Capture-MS Mus musculus
96 KRAS 3845
Negative Genetic Homo sapiens
97 HNRNPU 3192
Affinity Capture-MS Homo sapiens
98 RC3H1 149041
Affinity Capture-MS Homo sapiens
99 KIAA0408  
Affinity Capture-MS Homo sapiens
100 NAP1L5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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