Gene description for BRD3
Gene name bromodomain containing 3
Gene symbol BRD3
Other names/aliases ORFX
RING3L
Species Homo sapiens
 Database cross references - BRD3
ExoCarta ExoCarta_8019
Entrez Gene 8019
HGNC 1104
MIM 601541
UniProt Q15059  
 BRD3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for BRD3
Molecular Function
    protein binding GO:0005515 IPI
    lysine-acetylated histone binding GO:0070577 IDA
    chromatin binding GO:0003682 IDA
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    chromatin modification GO:0016568 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified BRD3 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for BRD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRD7  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which BRD3 is involved
No pathways found





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